Enantioselective Synthesis
of Chiral Sulfones by Ir-Catalyzed
Asymmetric Hydrogenation: A Facile Approach to the Preparation of
Chiral Allylic and Homoallylic Compounds
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Abstract
A highly efficient and enantioselective Ir-catalyzed
hydrogenation
of unsaturated sulfones was developed. Chiral cyclic and acyclic sulfones
were produced in excellent enantioselectivities (up to 98% ee). Coupled
with the Ramberg–Bäcklund rearrangement, this reaction
offers a novel route to chiral allylic and homoallylic compounds in
excellent enantioselectivities (up to 97% ee) and high yields (up
to 94%)
