Experimental exploration of the optomechanical attractor diagram and its dynamics

We demonstrate experimental exploration of the attractor diagram of an optomechanical system where the optical forces compensate for the mechanical losses. In this case stable self-induced oscillations occur but only for specific mirror amplitudes and laser detunings. We demonstrate that we can amplify the mechanical mode to an amplitude 500 times larger than the thermal amplitude at 300K. The lack of unstable or chaotic motion allows us to manipulate our system into a non-trivial steady state and explore the dynamics of self-induced oscillations in great detail.Comment: 6 pages, 4 figure

Coherent Optomechanical State Transfer between Disparate Mechanical Resonators

Hybrid quantum systems have been developed with various mechanical, optical and microwave harmonic oscillators. The coupling produces a rich library of interactions including two mode squeezing, swapping interactions, back-action evasion and thermal control. In a multimode mechanical system, coupling resonators of different scales (both in frequency and mass) leverages the advantages of each resonance. For example: a high frequency, easily manipulated resonator could be entangled with a low frequency massive object for tests of gravitational decoherence. Here we demonstrate coherent optomechanical state swapping between two spatially and frequency separated resonators with a mass ratio of 4. We find that, by using two laser beams far detuned from an optical cavity resonance, efficient state transfer is possible through a process very similar to STIRAP (Stimulated Raman Adiabatic Passage) in atomic physics. Although the demonstration is classical, the same technique can be used to generate entanglement between oscillators in the quantum regime

High-Q nested resonator in an actively stabilized optomechanical cavity

Experiments involving micro- and nanomechanical resonators need to be carefully designed to reduce mechanical environmental noise. A small scale on-chip approach is to add an additional resonator to the system as a mechanical low-pass filter. Unfortunately, the inherent low frequency of the low-pass filter causes the system to be easily excited mechanically. Fixating the additional resonator ensures that the resonator itself can not be excited by the environment. This, however, negates the purpose of the low-pass filter. We solve this apparent paradox by applying active feedback to the resonator, thereby minimizing the motion with respect the front mirror of an optomechanical cavity. Not only does this method actively stabilize the cavity length, but it also retains the on-chip vibration isolation.Comment: Minor adjustments mad

An Abbreviated Method for the Quality Control of Pollen Counters

We present an abbreviated method for conducting large scale quality control (QC) exercises over limited time periods, which was used for examining the proficiency of technicians involved in the electronic Pollen Information Network (ePIN). The goal was for technicians to have their analysis skills evaluated at least twice: (1) by having at least one of their slides successfully checked by other counters in the ePIN network and (2) by successfully examining at least one additional slide from other sites. Success was judged as a relative difference (RDif %) ≤ 30% between the two daily average pollen concentrations. A total of 21 sites participated in the ePIN QC exercise. All of the results for total pollen had RDif % 30%, three for Betula and two for Poaceae pollen. Of these, three were slides containing < 40 pollen/m3 daily average and two were for sites that had microscopes with small fields of view and examined < 10% of the slide surface. More than 80% of the participants had at least two slides successfully checked by someone else in the network, and all of the participants had one slide successfully examined. The latter is comparable to a traditional ring test where only one slide is sent to participating sites. The method described here enabled a large number of technicians to be examined in a short period of time and represents a viable alternative to other approaches that can take many months to complete

Where photons meet phonons

We investigate how radiation pressure can be used to influence the mechanical motion of a micro-mirror suspended from springs. This trampoline resonator is part of an optical Fabry-Perot cavity. By tuning the laser frequency with respect to the optical resonance, we are able to optically cool the mechanical motion of the resonator. When combining this optical cooling with cryogenic cooling techniques, we are able to bring the mechanical resonator close to the quantum mechanical ground state. This is a requirement for future experiments to investigate the fundamentals of quantum mechanics. Quantum Matter and Optic

Vibration isolation with high thermal conductance for a cryogen-free dilution refrigerator

We present the design and implementation of a mechanical low-pass filter vibration isolation used to reduce the vibrational noise in a cryogen-free dilution refrigerator operated at 10 mK, intended for scanning probe techniques. We discuss the design guidelines necessary to meet the competing requirements of having a low mechanical stiffness in combination with a high thermal conductance. We demonstrate the effectiveness of our approach by measuring the vibrational noise levels of an ultrasoft mechanical resonator positioned above a SQUID. Starting from a cryostat base temperature of 8 mK, the vibration isolation can be cooled to 10.5 mK, with a cooling power of 113 $\mu$W at 100 mK. We use the low vibrations and low temperature to demonstrate an effective cantilever temperature of less than 20 mK. This results in a force sensitivity of less than 500 zN/$\sqrt{\mathrm{Hz}}$, and an integrated frequency noise as low as 0.4 mHz in a 1 Hz measurement bandwidth

Environmental exposure and sensitization patterns in a Swiss alpine pediatric cohort

Background The level of environmental exposure throughout life may contribute to the prevalence of allergic sensitization and allergic disease. The alpine climate has been considered a healthy climate with little allergen exposure and pollution. We conducted a cross-sectional study to investigate local environmental exposure and concomitant prevalence of allergic sensitization among local school children born and raised in an alpine environment. Methods Clinical and demographic data were collected with a questionnaire. Allergen content was assessed in residential settled dust samples, lifetime exposure to pollen and air pollution was calculated using data from national pollen and air pollution monitoring stations, and the allergic sensitization profile was determined with component resolved diagnostics (ISAC®). Univariate and multivariate regression models were used to estimate the relation between exposure and sensitization. Results In a cohort of children born and raised in an alpine environment, sensitization to aeroallergens is quite common (38%), especially to grass (33%) and cat (16%). House dust mite allergen was detected in up to 38% of residential dust samples, but sensitization to HDM was low (2.5%). Pollutant levels were low, but an increasing trend was observed in the amount of ozone and PM10. Living close to a busy road was associated with increased odds OR (95% CI) for being sensitized to any allergen 2.7 (1.0–7.2), to outdoor allergens 2.8 (1.1–7.1) and being sensitized plus reporting symptoms of rhinoconjunctivitis 4.4 (1.3–14.8) and asthma 5.5 (1.4–21). Indoor living conditions, including the presence of visible mold, increased the odds of being sensitized to indoor allergens (1.9 (1.1–3.2) and being sensitized plus reporting symptoms of rhinoconjunctivitis 1.9 (1.0–3.6) and asthma 2.1 (1.0–4.1). Conclusion In a healthy alpine environment, pollution might still be an important factor contributing to allergic sensitization

Q. rotundifolia and P. hybrida pollen extracts induced basophil degranulation: study using a cell line expressing human FcERI.

Nowadays skin prick tests remain the favourite methodology in allergy diagnosis to aeroallergens. These tests, however, cause discomfort to the patient. Several biochemical methods are available but have limited diagnostic power as biological response, hence allergic reaction, is not predicted by these tests. A biological assay allowing the evaluation of allergic response to allergens is lacking. The aim of this work was to investigate the value of a rat basophil cell line expressing human high affinity IgE receptor (FcERI) for the evaluation of specific response to allergens. FACS analysis was used to determine FcERI expression (APC-A). Pollen extracts from different species were prepared with ammonium bicarbonate buffer, lyophilized and stored at -80ºC until use. Batches of RBL-h21 cells were sensitized with selected pools of human sera (purified IgE was used as control) and were stimulated with pollen extracts or Anti-IgE antibody. Histamine release (% degranulation) was determined a ß-hesoaminidase (tracer) assay. Batches of RBL-h21 cells sensitized (human sera) to grasses (D. glomerata), olive, oak or plane exhibited selective and dose-dependent degranulation upon selective stimulation with pollen extracts in the range of 1-200μg/mL. Maximal degranulation (>25%) was observed for 50, 120 and 62μg/mL for grass, oak and plane, respectively, while the lowest concentration with observed effect was 12μg/mL for any of the extracts. The results show that RBL-h21 cells sensitized with human sera exhibit specific and dose-dependent degranulation upon stimulation with pollen extract containing allergens suggesting this bioassay may constitute a useful tool to evaluate allergic responses both for research and/or diagnostics