Pengaruh Madu Terhadap Gambaran Mikroskopis Testis Pada Tikus Wistar Yang Diinduksi Monosodium Glutamat

Background: Monosodium glutamate (MSG) is a food seasoning that is often consumed excessively although it is harmful to the body, including on testis. The harmful effect of MSG on testis must be highlighted because it can leaf to infertility. Honey as an antioxidant can counteract the harmful effects of MSG on testis.Aim: To prove the effect of multi level doses of honey on microscopic structure of testis in wistar rats induced to monosodium glutamate.Methods: True experimental study "post test only control group design"using 18 wistar rats were divided into 3 groups, P1 was administered MSG 6 mg/g BW/day, P2 was adminstered MSG 6 mg/g BW/day then honey 2 g/200 g BW/day, P3 was adminstered MSG 6 mg/g BW/day then honey 4 g/200 g BW/day. The treatment was 30 days, then the rats were terminated and the microscopic structure of testis was observed with Johnsen Criteria.Results: P1 showed histological structural damage of testis and 80% of seminiferous tubules were in the category of early maturity arrest. P2 showed the repairment of histology structure of testis compared to P1 and 73.33% seminiferous tubules were in the category of late maturity arrest. P3 showed better histological structure of testis compared to others and 53.33% of the seminiferous tubules in the category of obstructive cases/normal. Hypothesis test showed significant difference between each group ( p<0.05).Conclusions: Administration of multi level doses of honey give protective effect to the histological structure of testis which was exposed to MSG

Penyakit Stroke dan Infeksi Corona Virus Disease 2019 (COVID-19): sebuah Tinjauan Literatur

Latar belakang: Corona virus disease 2019 (COVID-19) adalah suatu penyakit yang disebabkan oleh virus severe acute resporatory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 awalnya diketahui menyerang saluran pernapasan, namun sekarang ini manifestasi klinisnya beragam termasuk manifestasi kelainan saraf/neurologis. Kelainan neurologis yang perlu mendapat perhatian khusus karena morbiditas dan mortalitasnya yang dapat ditekan bila ditangani secara tepat waktu adalah kasus penyakit serebrovaskular/stroke. Tujuan dari tinjauan literatur ini adalah mengkaji secara teori berdasarkan literatur tentang hubungan infeksi COVID-19 dan stroke. Metode: Review literatur Pembahasan: Stroke pada COVID-19 berhubungan dengan koagulopati, antibodi antifosfolipid, dan vaskulitis. Manifestasi klinis, pemeriksaan penunjang, dan penanganan pada kasus stroke dengan COVID-19 butuh mendapat perhatian khusus. Penanganan pada stroke dengan COVID-19 difokuskan kepada keselamatan pasien dan keamanan tenaga kesehatan. Simpulan: Vasokontriksi serebral, peradangan saraf, stres oksidatif, dan trombogenesis dapat berkontribusi terhadap patofisiologi stroke selama infeksi COVID-19. Protokol perawatan di rumah sakit harus dimodifikasi untuk memberikan perawatan individual yang lebih baik untuk pasien stroke disertai COVID-19 dan keamanan bagi tenaga kesehatan