20 research outputs found
Unwrapping Closed Timelike Curves
Closed timelike curves (CTCs) appear in many solutions of the Einstein
equation, even with reasonable matter sources. These solutions appear to
violate causality and so are considered problematic. Since CTCs reflect the
global properties of a spacetime, one can attempt to change its topology,
without changing its geometry, in such a way that the former CTCs are no longer
closed in the new spacetime. This procedure is informally known as unwrapping.
However, changes in global identifications tend to lead to local effects, and
unwrapping is no exception, as it introduces a special kind of singularity,
called quasi-regular. This "unwrapping" singularity is similar to the string
singularities. We give two examples of unwrapping of essentially 2+1
dimensional spacetimes with CTCs, the Gott spacetime and the Godel universe. We
show that the unwrapped Gott spacetime, while singular, is at least devoid of
CTCs. In contrast, the unwrapped Godel spacetime still contains CTCs through
every point. A "multiple unwrapping" procedure is devised to remove the
remaining circular CTCs. We conclude that, based on the two spacetimes we
investigated, CTCs appearing in the solutions of the Einstein equation are not
simply a mathematical artifact of coordinate identifications, but are indeed a
necessary consequence of General Relativity, provided only that we demand these
solutions do not possess naked quasi-regular singularities.Comment: 29 pages, 9 figure
Active fixturing: literature review and future research directions
Fixtures are used to fixate, position and support workpieces and represent a crucial tool in manufacturing. Their performance determines the result of the whole manufacturing process of a product. There is a vast amount of research done on automatic fixture layout synthesis and optimisation and fixture design verification. Most of this work considers fixture mechanics to be static and the fixture elements to be passive. However, a new generation of fixtures has emerged that has actuated fixture elements for active control of the part–fixture system during manufacturing operations to increase the end product quality. This paper analyses the latest studies in the field of active fixture design and its relationship with flexible and reconfigurable fixturing systems. First, a brief introduction is given on the importance of research of fixturing systems. Secondly, the basics of workholding and fixture design are visited, after which the state-of-the-art in active fixturing and related concepts is presented. Fourthly, part–fixture dynamics and design strategies which take these into account are discussed. Fifthly, the control strategies used in active fixturing systems are examined. Finally, some final conclusions and prospective future research directions are presented
Temperature analysis for the laser-assisted tape winding process of multi-layered composite pipes
COMMERCIAL AND MONETARY POLICY IN A NORTH-SOUTH MACROECONOMIC MODEL: TARIFFS AND VERs COMPARED
Esterification of cholesterol in human small intestine: the importance of acyl-CoA:cholesterol acyltransferase
The Global Alliance for Infections in Surgery: defining a model for antimicrobial stewardship-results from an international cross-sectional survey
Contains fulltext :
177987.pdf (publisher's version ) (Open Access)BACKGROUND: Antimicrobial Stewardship Programs (ASPs) have been promoted to optimize antimicrobial usage and patient outcomes, and to reduce the emergence of antimicrobial-resistant organisms. However, the best strategies for an ASP are not definitively established and are likely to vary based on local culture, policy, and routine clinical practice, and probably limited resources in middle-income countries. The aim of this study is to evaluate structures and resources of antimicrobial stewardship teams (ASTs) in surgical departments from different regions of the world. METHODS: A cross-sectional web-based survey was conducted in 2016 on 173 physicians who participated in the AGORA (Antimicrobials: A Global Alliance for Optimizing their Rational Use in Intra-Abdominal Infections) project and on 658 international experts in the fields of ASPs, infection control, and infections in surgery. RESULTS: The response rate was 19.4%. One hundred fifty-six (98.7%) participants stated their hospital had a multidisciplinary AST. The median number of physicians working inside the team was five [interquartile range 4-6]. An infectious disease specialist, a microbiologist and an infection control specialist were, respectively, present in 80.1, 76.3, and 67.9% of the ASTs. A surgeon was a component in 59.0% of cases and was significantly more likely to be present in university hospitals (89.5%, p < 0.05) compared to community teaching (83.3%) and community hospitals (66.7%). Protocols for pre-operative prophylaxis and for antimicrobial treatment of surgical infections were respectively implemented in 96.2 and 82.3% of the hospitals. The majority of the surgical departments implemented both persuasive and restrictive interventions (72.8%). The most common types of interventions in surgical departments were dissemination of educational materials (62.5%), expert approval (61.0%), audit and feedback (55.1%), educational outreach (53.7%), and compulsory order forms (51.5%). CONCLUSION: The survey showed a heterogeneous organization of ASPs worldwide, demonstrating the necessity of a multidisciplinary and collaborative approach in the battle against antimicrobial resistance in surgical infections, and the importance of educational efforts towards this goal