10 research outputs found
Supplemental material - Preparation and characterization of highly heat-resistant, soluble, and hydrophobic fluorinated polyimides with gas transport properties
Supplemental material for Preparation and characterization of highly heat-resistant, soluble, and hydrophobic fluorinated polyimides with gas transport properties by Yufei Shi, Jinling Li, Weilian Wu, Jing Ni, Bowen Wei, Chanjuan Liu and Xiaohua Huang in High Performance Polymers.</p
Tracing Deep Carbon Cycling by Zinc Isotopes in a PeralkalineāCarbonatite Suite
Sedimentary carbonates are known to be carried into the deep mantle by subducted slabs, and studies on mantleāderived magmas have attempted to trace the recycled carbonate in their mantle source. However, the final depth of storage of recycled carbonate and the role of recycled carbonate in the partial melting of mantle remain controversial. Peralkalineācarbonatite suites are considered to have been derived from a carbonated mantle source and are windows to evaluate carbon in the mantle. In this study, we report the Zn isotopic compositions of a peralkalineācarbonatite suite from the Tarim Large Igneous Province (Tarim LIP). The peralkalineācarbonatite suite has heavier Ī“66Zn than normal mantle with Ī“66Zn of 0.34ā0.40 ā° for nephelinite, 0.35ā0.47 ā° for aillikite, 0.51ā0.55 ā° for nepheline syenite, 0.58ā0.67 ā° for calciocarbonatite and 0.38ā0.56 ā° for magnesiocarbonatite. The heavy Zn isotopic compositions of the peralkalineācarbonatite suite in the Wajilitag complex suggest the incorporation of recycled carbonateābearing materials into the deep mantle. We infer that the calciocarbonatite was produced by the initial partial melting of subducted MgSiO3/MgOĀ +Ā Cābearing carbonated eclogite, whereas the magnesiocarbonatite, aillikite, and nephelinite are considered as reacted melts between carbonated eclogiteāderived melts and peridotite. The heavy Zn isotopic compositions of the nepheline syenite are attributed to fractional crystallization from nephelinite magma in the magma reservoir. Our study highlights the incorporation of carbonated eclogite as an important agent of recycled carbon in the deep mantle and interactions between carbonated eclogiteāderived melts and peridotite lead to the complex lithological heterogeneities in the peralkalineācarbonatite suite in Tarim LIP.</p
Correlations of the expression level of RPS11, the status of MGMT methylation, IDH mutation and age with patient survival.
<p>Each indicated factor was analyzed as an independent prognostic factor. Changes in relative risk were depicted with Kaplan-Meier curves and analyzed using log-rank tests.</p
Modeling of protein expression (H-score) cutoffs for low vs. high protein expression.
<p>Each curve reports the score of a Cox Proportional Hazards model associated with different cut-off values of the related protein expression to bin scores into Low versus High expression. Protein expression is measured as the H score rescaled to (0ā3). Optimal cut-offs are identified as the mode in the cut-off vs. score curve. For VEGFA, this was not identifiable and an 80<sup>th</sup> percentile H-score was used as a cut-off.</p
Representative outputs of Probe Set Analyzer for selected molecular signatures of TRGC.
<p>A real-time correlation of patient survival and gene expression levels of selected signatures of TRGC was performed using Probe Set Analyzer (<a href="http://probesetanalyzer.com/index.aspx" target="_blank">http://probesetanalyzer.com/index.aspx</a>). āNewly Diagnosed", āRecurrent" or ācombined all tumorsā were analyzed. The y-axis represents normalized gene expression intensity, and the x-axis represents patient groups. The sliding bars position patients into high, mid and low gene expression level groups. A Kaplan-Meier curve with corresponding p-values is generated based on each change to these patient groups. An integrated statistical engine calculated p-values based on Kaplan-Meier curves.</p
Tissue microarray protein expression- Cox proportional hazard analysis (primary GBMs only).
<p>Tissue microarray protein expression- Cox proportional hazard analysis (primary GBMs only).</p
Correlation with poor survival in newly diagnosed and recurrent GBMs (primary and secondary GBMs included).
<p>Correlation with poor survival in newly diagnosed and recurrent GBMs (primary and secondary GBMs included).</p
Tissue microarray protein expression- Cox proportional hazard analysis (primary and secondary GBMs included).
<p>Tissue microarray protein expression- Cox proportional hazard analysis (primary and secondary GBMs included).</p
Kaplan-Meier survival curves for newly diagnosed and recurrent GBMs expressed differential levels of selected signatures of TRGC.
<p>These survival curves for RPS11, RPS20, and VEGFA correspond to the Cox Proportional Hazards data in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0141334#pone.0141334.t001" target="_blank">Table 1</a>. Both primary and secondary GBMs were included in the analyses.</p
Upregulation of protein levels of TRGC signatures in GBM subgroups correlates with patients' poor prognosis.
<p>Representative immunohistochemical staining of RPS11 and RPS20 in clinical GBM subgroups. Upregulation of RPS11 was found to increase the hazard of death (HOD) 11-fold in newly diagnosed primary GBM (a, b) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0141334#pone.0141334.t002" target="_blank">Table 2</a>) and 7-fold in a secondary GBM (c, d) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0141334#pone.0141334.s004" target="_blank">S2 Table</a>). Upregulation of RPS20 was found to increase the HOD 5-fold in newly diagnosed primary GBM (e, f) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0141334#pone.0141334.t002" target="_blank">Table 2</a>). The survival times of each representative patient are shown.</p