The Tunisian exchange rate regime: Is it really floating?

Financial statistics on exchange rates et foreign reservesTHIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Tunisian Foreign Debt Data

Quarterly data of the Tunisian foreign debt and some other indicators (savings, exchange, current deficit, ...)THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

Projet de recherche pour le développement de l'agriculture d'oasis. Caractéristiques des principales variétés de dattes tunisiennes

La caractérisation des 21 principales dattes provenant du Djérid (sud tunisien), tant au niveau pomologique que physico-chimique a permis d'établir un comparatif des résultats avec la principale datte exportée qu'est la 'Deglet Nour'. Il a été noté des caractéristiques pomologiques particulièrement intéressantes pour les variétés 'Ménakher', 'Boufagous', 'Trongea' si elles sont comparées à celle de la variété 'Deglet Nour'. Ces mêmes dattes, ainsi que les variétés 'Zahidi', 'Kenta', 'Angou' peuvent être considérées comme de qualité demi-molle. Les teneurs en acides aminés sont très hétérogènes : si la variété 'Kentichi' possède 82 mg/100 gr de M.S. en acides aminés totaux, 'Bser Halou' a une teneur de près de 700 mg/100 gr de M.S. Les fortes teneurs en malate ont été relevées chez les dattes considérées comme sèches ('Kentichi', 'Farmla'). (Résumé d'auteur

ARE CAPABILITY INDICES USEFULL TO ASSESS ANALYTICAL METHODS VALIDITY ?

Analytical methods capability evaluation can be a useful methodology to assess the fitness of purpose of these methods for their future routine application. However, care on how to compute the capability indices has to be made. Indeed, the commonly used formulas to compute capability indices such as Cpk, will highly overestimate the true capability of the methods. Especially during methods validation or transfer, there are only few experiments performed and, using in these situations the commonly applied capability indices to declare a method as valid or as transferable to a receiving laboratory will conduct to inadequate decisions. In this work, an improved capability index, namely Cpk-tol and the corresponding estimator of proportion of non conforming results ( ) is proposed. Through Monte-Carlo simulations, they have been shown to greatly increase the estimation of analytical methods capability in particular in low sample size situations as encountered during methods validation or transfer. Additionally, the usefulness of this capability index is illustrated through several case studies covering applications commonly encountered in the pharmaceutical industry. Finally a methodology to determine the optimal sample size required to validate analytical methods is also given using the proposed capability metric

Flexibility and Applicability of β-expectation tolerance interval approach to assess the fitness of purpose of pharmaceutical analytical methods

An innovative versatile strategy using Total Error has been proposed to decide about the method’s validity that controls the risk of accepting an unsuitable assay together with the ability to predict the reliability of future results. This strategy is based on the simultaneous combination of systematic (bias) and random (imprecision) error of analytical methods. Using validation standards both types of error are combined through the use of a prediction interval or β-expectation tolerance interval. Finally, an accuracy profile is built by connecting, on one hand all the upper tolerance limits, and on the other hand all the lower tolerance limits. This profile combined with pre-specified acceptance limits allows to evaluate the validity of any quantitative analytical method and thus their fitness for their intended purpose. In this work, the approach of accuracy profile was evaluated on several types of analytical methods encountered in pharmaceutical industrial field and also covering different pharmaceutical matrices. The four studied examples depicted the flexibility and applicability of this approach for different matrices ranging from tablets to syrups, different techniques such as liquid chromatography, or UV spectrophotometry and for different categories of assays commonly encountered in the pharmaceutical industry that are content assays, dissolution assays and quantitative impurity assays. The accuracy profile approach assesses the fitness of purpose of these methods for their future routine application,. It also allows to select the most suitable calibration curve, to evaluate adequately a potential matrix effect and propose efficient solution and to define correctly the limits of quantification of the studied analytical procedures