Entomologic and Virologic Investigation of Chikungunya, Singapore

Data from longitudinal analyses can be useful in the design and implementation of control strategies

Fatigue study on 3D cracks initiated at corrosion zone in offshore pipelines

Pipelines, which often consists of long circular structures welded together, are major oil and gas industry tools used in exploration, drilling, production, and that installing and operating these structures in deep waters places unique demands on them. The technical challenges of these field since then have spawned significant research and development efforts in a broad range of area. One of the many areas of research include the investigation on the effect of corrosion under fatigue conditions. [1] Corrosion is often one of the main reasons for structural degradation in offshore structures. It affects the life of pipelines and often leads to catastrophic failure, leakage, loss of product, pollution to the environment, and in some cases loss of life. In all the various forms of corrosion, pitting corrosion is identified as the most hazardous of them all. Pitting corrosion is a localised accelerated dissolution of metal that occurs as a numerous real-life factor such as temperature, variable loads, vibration, and microbial activities reduces the effectiveness of the various protective layers on the metal surface. [2] The current study presents the investigation on the fatigue behaviour using the theory of finite element method to simulate the fatigue behaviour of various scenario of 3 dimensional semi-elliptical cracks under a cyclic tensile force by using ANSYS Workbench 19.2. The focus is to investigate the influence of corrosion on the cracks that are present within the steel structures.Bachelor of Engineering (Mechanical Engineering

Contract employment in Singapore : a human resource perspective.

This is a research study on the human resource perspectives of Contract Employment in the Singapore context. HR Issues of Recruitment and Selection, Compensation and Benefits, Training and Development, and Performance Appraisal were discussed in relation to Contract Employment

A study of stochastic processes of asset pricing

Wherever there are valuable assets to be traded, there are incentives to develop markets to organise that trade more efficiently. In modern societies the securities markets are usually among the best organised and virtually always the largest in terms of value of sales. The largest in terms of value of sales. The prices of such securities are typically very sensitive, responsive to all events, that cast light into the hazy future.BUSINES

CDNA SEQUENCE OF DENGUE VIRUS SEROTYPE 1 (SINGAPORE STRAIN)

EP0638122B1Granted Paten

CDNA SEQUENCE OF DENGUE VIRUS SEROTYPE 1 (SINGAPORE STRAIN)

WO1993022440A1Published Applicatio

CDNA SEQUENCE OF DENGUE VIRUS SEROTYPE 1 (SINGAPORE STRAIN)

EP0638122A1Published Applicatio

A Circulating miRNA Signature for Stratification of Breast Lesions among Women with Abnormal Screening Mammograms

Although mammography is the gold standard for breast cancer screening, the high rates of false-positive mammograms remain a concern. Thus, there is an unmet clinical need for a non-invasive and reliable test to differentiate between malignant and benign breast lesions in order to avoid subjecting patients with abnormal mammograms to unnecessary follow-up diagnostic procedures. Serum samples from 116 malignant breast lesions and 64 benign breast lesions were comprehensively profiled for 2,083 microRNAs (miRNAs) using next-generation sequencing. Of the 180 samples profiled, three outliers were removed based on the principal component analysis (PCA), and the remaining samples were divided into training (n = 125) and test (n = 52) sets at a 70:30 ratio for further analysis. In the training set, significantly differentially expressed miRNAs (adjusted p < 0.01) were identified after correcting for multiple testing using a false discovery rate. Subsequently, a predictive classification model using an eight-miRNA signature and a Bayesian logistic regression algorithm was developed. Based on the receiver operating characteristic (ROC) curve analysis in the test set, the model could achieve an area under the curve (AUC) of 0.9542. Together, this study demonstrates the potential use of circulating miRNAs as an adjunct test to stratify breast lesions in patients with abnormal screening mammograms

Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial.

BACKGROUND: Dengue infection is the most common mosquito-borne viral disease worldwide, but no suitable antiviral drugs are available. We tested the α-glucosidase inhibitor celgosivir as a treatment for acute dengue fever. METHODS: To establish eligibility for inclusion in a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trial, individuals aged 21-65 years who had had a fever (≥38°C) for less than 48 h, met at least two criteria indicating probable dengue infection, and had a positive result on a dengue point-of-care test kit or PCR assay were referred for screening at a centre in Singapore between July 30, 2012, and March 4, 2013. Using a web-based system, we randomly assigned patients who met full inclusion criteria after screening (1:1; random permuted block length four) to celgosivir (initial 400 mg loading dose within 6 h of randomisation, followed by 200 mg every 12 h for a total of nine doses) or matched placebo. Patients and the entire study team were masked to group assignment. The primary endpoints were mean virological log reduction (VLR) from baseline for days 2, 3, and 4, and area under the fever curve (AUC) for a temperature above 37°C from 0 h to 96 h. Efficacy analyses were by intention to treat. This study is registered with ClinicalTrials.gov, number NCT01619969. FINDINGS: We screened 69 patients and randomly assigned 50 (24 to celgosivir, 26 to placebo). Mean VLR was greater in the celgosivir group (-1·86, SD 1·07) than in the placebo group (-1·64, 0·75), but the difference was non-significant (-0·22, 90% CI -0·65 to 0·22; one-sided p=0·203). The mean AUC was also higher in the celgosivir group (54·92, SD 31·04) than in the placebo group (40·72, 18·69), but again the difference was non-significant (14·20, 90% CI 2·16-26·25; one-sided p=0·973). We noted similar incidences of adverse events between groups. INTERPRETATION: Although generally safe and well tolerated, celgosivir does not seem to reduce viral load or fever burden in patients with dengue. FUNDING: STOP Dengue Translational Clinical Research