Data from longitudinal analyses can be useful in the design and implementation of control strategies

Boon-Hian Tan

Carey

Cheong-Huat Tan

Göran Bucht

Hall

Hammon

Hapuarachchi

Hapuarachchige C. Hapuarachchi

Hasebe

Hwi-Kwang Han

Khan

Kumar

Kwoon-Yong Pok

Lee-Ching Ng

Li-Kiang Tan

Lyn James

Noridah

Parola

Peng-Lim S Ooi

Powers

Raymond T.P. Lin

Reiter

Rezza

Robinson

Sai-Gek Lam-Phua

Schuffenecker

Seow-Poh Khoo

Shah

Sharon S.Y. Tan

Tsetsarkin

Yee-Ling Lai

Yee-Sin Leo

Yergolkar

Emerging Infectious Diseases

English

PubMed

10.3201/eid1508.081486Emerging Infectious Diseases1581243-124

Ng, L.-C

Tan, L.-K

Tan, C.-H

Tan, S.S.Y

Hapuarachchi, H.C

Pok, K.-Y

Lai, Y.-L

Lam-Phua, S.-G

Bucht, G

Lin, R.T.P

Leo, Y.-S

Tan, B.-H

Han, H.-K

Ooi, P.-L.S

James, L

Khoo, S.-P

ScholarBank@NUS

Entomologic and virologic investigation of chikungunya, Singapore

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Entomologic and Virologic Investigation of Chikungunya, Singapore

Local transmission of chikungunya, a debilitating mosquito-borne viral disease, was first reported in Singapore in January 2008. After 3 months of absence, locally acquired Chikungunya cases resurfaced in May 2008, causing an outbreak that resulted in a total of 231 cases by September 2008. The circulating viruses were related to East, Central, and South African genotypes that emerged in the Indian Ocean region in 2005. The first local outbreak was due to a wild-type virus (alanine at codon 226 of the envelope 1 gene) and occurred in an area where Aedes aegypti mosquitoes were the primary vector. Strains isolated during subsequent outbreaks showed alanine to valine substitution (A226V) and largely spread in areas predominated by Ae. albopictus mosquitoes. These findings led to a revision of the current vector control strategy in Singapore. This report highlights the use of entomologic and virologic data to assist in the control of chikungunya in disease-endemic areas

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10.1016/j.virusres.2008.02.004

A226V mutation in virus during the 2007 chikungunya outbreak

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http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2815960

Entomologic and Virologic Investigation of Chikungunya, Singapore

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Directory of Open Access Journals