Labor opportunism of the personnel of medical institution

© 2015, Mediterranean Center of Social and Educational Research. All rights reserved. Methods of identification and quantitative assessment of level of labor opportunism of the personnel on the basis of the analysis of labor opportunism of the personnel of a clinical oncologic dispensary, forms of its manifestation in the organization in view of various hierarchical levels of official categories of workers are analyzed in this article. The special attention is paid to research of the reasons of emergence of labor opportunism of employees

Main causes of staff labor opportunism in organizations

This article provides an analysis of the reasons for the occurrence of opportunism amongst staff in organizations. Using the results of a staff survey, research was carried out into correlation-regression dependencies of the factors that cause different forms of labor opportunism amongst different categories of workers: managers and their subordinates. On the basis of a quantitative assessment of the level of labor opportunism, the article estimates the inclination towards opportunism in the context of different categories of staff, and ascertains conditions of stability in the occurrence of labor opportunism in the organization. The research conducted into the nature of interference of labor opportunism between managers and subordinates provides evidence that the opportunism of the staff is a response to the opportunism of their superiors

Russia and Germany in the life of the American diplomat George Frost Kennan (toward his 110^th birthday)

© The authors. A well-known American diplomat and historian George Frost Kennan's (1904-2005) activities studying is still a live issue today and brings us to a different regarding of the key aspects of international relations in the XXth century. Kennan is one of the founders of ideas of "political realism" in the history and theory of international relations and "power equation" in geopolitics as well as the author of the famous "doctrine of containment" which had provided the basis for the USA foreign policy for decades. In this regard the article is aimed at the complex evaluating of the role of Germany and Russia in the life of the American diplomat George Frost Kennan. While working on this article we used a historical-comparative approach enabling comparison of different events and different points of view as well as his own ones during different periods of his life. When studying the role of Russia in Kennan's life, it should be noted that with it his very first and bright diplomatic appointments are connected and they allowed exploring the Russian political system, developing a passion for the Russian culture, learning the Russian people, whom he had admired through his life. "Russian issue" had always been the cornerstone of not only Kennan's diplomatic, but also academic and social-political career. The German issue had also been widely regarded in the work of the diplomat

Synthesis of new pinane-type hetarylsulfides

© 2014 Springer Science+Business Media New York. New bicyclic thioterpenoids with heterocyclic fragments were prepared via reactions of (-)-β-pinene and its oxide with 1-phenyl-1H-tetrazole-5-thiol, 1-methylimidazole-2-thiol, and 4,6-dimethyl-2-pyrimidinesulfenylchloride

Extraordinary behavior of β-hydroxy sulfoxides and sulfone of pinane series

© 2017 Taylor & Francis Group, LLC.The “racemic compound-like” behavior, low-temperature conformational rearrangement and “crystallization-induced diastereomerization” of β-hydroxysulfoxides and sulfone of pinane series have been studied. It was established, that the sample of sulfoxide crystallizes as an asymmetric dimer containing a supramolecularcentro-symmetric moiety formed through S=O···H‒O interactions between two independent molecules. Moreover, it was found that this dimer can crystallize in two so-called “packing polymorphs”—monoclinic and triclinic ones. By transition from the room temperature to 150 К for both polymorphic forms conformational restructuring of a stable hydrogen-bonded synthon from “unfolded” form to “folded” one has been observed. The sample of sulfoxide is interesting as the first example of the co-crystallization of chiral sulfur compounds. Surprisingly we have found a similar H-bonded dimer, formed by independent molecules, where all sulfone molecules are identical in stereochemical aspect. We suggested to use the new term “crystallization-induced diastereomerization” for the description of the stereochemical process leading to the formation of sulfone dimer. From a supramolecular chemistry point of view, we can speak of the finding of a new robust and reproducible synthon. From a stereochemical point of view, an “enantiophilic” fragment was discovered—a β-hydroxysulfoxide or sulfone group, capable of recognizing its mirror image

When two symmetrically independent molecules must be different: "crystallization-induced diastereomerization" of chiral pinanyl sulfone

According to X-ray data, homochiral pinanyl sulfone crystallizes as an asymmetric dimer formed by pairwise H-bonds involving stereochemically different oxygen atoms of sulfonyl groups of molecules A and B. Thus, a pro-R atom is invoked for the construction of a relevant H-bond in molecule A, but in the case of molecule B only a pro-S atom is involved. Newly formed chiral sulfur atoms take opposite chirality in molecules A and B, while the configuration of the pinane skeleton remains unchanged. Such a stereochemical transformation is called "crystallization-induced diastereomerization". The stability of the asymmetric dimer found in the crystal was evaluated within the framework of DFT (B3LYP, 6-31G (d,p)) and studied via IR spectroscopy in solution. This journal is © the Partner Organisations 2014

Study of "racemic compound-like" behavior of diastereomeric mixture of pinanyl sulfoxides by x-ray diffraction, ir spectroscopy, and DFT calculations

The oxidation of a β-hydroxysulfide in the pinane series by use of mchloroperbenzoic acid resulted in the formation of the corresponding β-hydroxysulfoxide as a mixture of two diastereomers in 4:5 ratio. According to single-crystal X-ray diffraction (XRD) results, it is established that the diastereomeric mixture of sulfoxides crystallizes in the "racemic compound-like" manner under formation of asymmetric dimers through S=O··H-O interactions. This asymmetric dimer formed from diastereomeric molecules is a structural unit in both crystal modifications, the triclinic and the monoclinic one. The behavior of the diastereomeric mixture of pinane derived sulfoxides in crystals, melts and in tetrachloromethane solutions was studied by IR spectroscopy. The density functional theory (DFT) method with 6-31G (d, p) basis set was used to calculate the optimized geometrical parameters and vibrational frequencies of different associates in solution. The calculated vibrational frequencies are compared with experimental IR spectra. Copyright © 2014 Taylor & Francis Group, LLC

Development of Approaches to the Study of the Interaction of Biologically Active Thioterpenoids with Model Membranes

© 2017, Springer Science+Business Media, LLC. It was shown that the synthesized camphene sulfone, in contrast to acetylsalicylic acid and clopidogrel, completely inhibits the activation of platelets induced by adrenaline and arachidonic acid, and reduces the influence of ADP, collagen, and ristocetin. Detailed NMR studies and molecular dynamics simulations using model SDS membranes indicated that the sulfone is embedded by its bicyclic part inside the SDS micelle, whereas -SO 2 (CH 2 ) 2 OH fragment of sulfone is located on the outer part of the micelle and accessible for solvent. It was ascertained that hemocoagulant activity of sulfone is caused by its capability of inhibition of platelet activation and suppression of catalytic activity of phospholipid surface participating in formation of coagulation complexes of clotting factors

S=O...S=O Interactions as a Driving Force for Low-Temperature Conformational Rearrangement of Stable H-Bonding {S(O)-Ch2-Ch2-OH···}2 Synthon in two Modifications of Diastereomeric Pinanyl Sulfoxides Co-Crystal

Copyright © Taylor & Francis Group, LLC. (Graphical Abstract) For the triclinic and monoclinic modifications of diastereomeric pinanyl sulfoxides co-crystal, remarkable alterations in unit cell parameters by transition from 293 to 150 were ascertained. Such alterations are accompanied by conformational restructuring of a stable hydrogen-bonded synthon from an "unfolded" to a "folded" form. The driving force of this restructuring is the tendency to form S=O.S=O interactions, which show up in the lowerature phases of both polymorphs. These are well-supported by the methods of quantum chemistry (DFT, B97-D/6-31G(d,p), AIM All)