6,070 research outputs found
Diagnose von Weichteiltumoren in der Zytologie
Zusammenfassung: Weichteilschwellungen sind das Symptom einer Vielzahl von neoplastischen und nichtneoplastischen Veränderungen. Sarkome gehören zu den selteneren Ursachen. Die Feinnadelpunktion hat sich in der Abklärung von Tumorrezidiven und Karzinommetastasen als minimal-invasive, kostengünstige und zuverlässige Methode bewährt. Auch in der Abklärung von Weichteiltumoren kann sie zu einer präzisen Diagnose führen. Voraussetzung ist eine enge multidisziplinäre Zusammenarbeit unter Einbeziehung klinischer, radiologischer und morphologischer Befunde. Für die zytologische Befundung sind Alter und Geschlecht sowie Topographie, Größe und Wachstumsgeschwindigkeit des Tumors wichtige Parameter. Reifungsgrad und Form der Zellen sowie Vorhandensein und Ausdifferenzierung der bindegewebigen Matrix bieten erste differenzialdiagnostische Hinweise und sind der Ausgangspunkt für immunzytochemische und molekularbiologische (FISH, RT-PCR) Zusatzuntersuchen. Diese Untersuchungen werden an Direktausstrichen, an mittels Zellblockmethode eingebettetem und an tiefgefrorenem Punktionsmaterial ausgeführ
Zytologische Sarkomdiagnostik
Zusammenfassung: Weichteilschwellungen sind das Symptom einer Vielzahl neoplastischer und nichtneoplastischer Veränderungen. Sarkome gehören zu den selteneren Ursachen. Die Feinnadelpunktion (FNP) hat sich in der Abgrenzung zu entzündlichen Prozessen sowie in der Abklärung von Tumorrezidiven und Karzinommetastasen als minimal-invasive, kostengünstige und zuverlässige Methode bewährt. Auch in der Abklärung von Weichteiltumoren kann sie zu einer präzisen Diagnose führen. Voraussetzung ist eine enge multidisziplinäre Zusammenarbeit unter Einbeziehung klinischer, radiologischer und morphologischer Befunde. Für die zytologische Befundung sind Alter und Geschlecht sowie Topographie, Größe und Wachstumsgeschwindigkeit des Tumors wichtige Parameter. Reifungsgrad und Form der Zellen sowie Vorhandensein und Ausdifferenzierung der bindegewebigen Matrix bieten erste differenzialdiagnostische Hinweise und sind der Ausgangspunkt für immunzytochemische und molekularbiologische (FISH, RT-PCR) Zusatzuntersuchungen. Diese Untersuchungen werden an Direktausstrichen, an mittels Zellblockmethode eingebettetem und an tiefgefrorenem Punktionsmaterial ausgeführ
Rolle der Zytologie in der hämatopathologischen Diagnostik
Zusammenfassung: Die Zytologie stellt ein wichtiges diagnostisches Instrument in der täglichen Praxis der Hämatopathologie dar. Durch den zytologisch erfolgten Nachweis nichthämatologischer Ursachen einer Knotenbildung (z.B. Speicheldrüsenneoplasien, Tuberkulose, Melanom- oder Karzinommetastasen) besteht seltener die Notwendigkeit einer chirurgischen Exzision. Die kombinierte Anwendung morphologischer, immunphänotypischer sowie molekularer Analysen und der fachliche Austausch machen diese Untersuchungstechnik sicher. Somit stellt die zytologische Untersuchung in verschiedensten Situationen eine Alternative zur Exzisionsbiopsie dar - auch bei primären hämatologischen Erkrankungen und insbesondere bei Rezidive
Spin-polarized surface states close to adatoms on Cu(111)
We present a theoretical study of surface states close to 3d transition metal
adatoms (Cr, Mn, Fe, Co, Ni and Cu) on a Cu(111) surface in terms of an
embedding technique using the fully relativistic Korringa-Kohn-Rostoker method.
For each of the adatoms we found resonances in the s-like states to be
attributed to a localization of the surface states in the presence of an
impurity. We studied the change of the s-like densities of states in the
vicinity of the surface state band-edge due to scattering effects mediated via
the adatom's d-orbitals. The obtained results show that a magnetic impurity
causes spin-polarization of the surface states. In particular, the long-range
oscillations of the spin-polarized s-like density of states around an Fe adatom
are demonstrated.Comment: 5 pages, 5 figures, submitted to PR
Determination of the Her-2/neu gene amplification status in cytologic breast cancer specimens using automated silver-enhanced in-situ hybridization (SISH)
Silver-enhanced in-situ hybridization (SISH) is an emerging tool for the determination of the Her-2/neu amplification status in breast cancer. SISH is technically comparable to fluorescence in-situ hybridization (FISH) but does not require a fluorescence microscope for its interpretation. Although recent studies on histologic evaluations of SISH are promising, we aimed to evaluate its performance on 71 cytologic breast cancer specimens with the new combined Her-2/Chr17 probe. Her-2/neu status as routinely determined by FISH was available for all patients. We found SISH signals in cytologic cell blocks and smear specimens easy to evaluate in most cases. Small numbers of tumor cells and difficulties in identifying tumor cells in lymphocyte-rich backgrounds were limiting factors. Her-2/neu status, as determined by Her-2/Chr17 SISH, was basically identical to the results of the corresponding FISH. The discrepancies were mainly owing to the heterogeneity of Her-2/neu amplification in the tumor tissue. Interobserver agreement for the SISH evaluation was high (kappa value: 0.972). We conclude that Her-2/Chr17 SISH is a useful and accurate method for the evaluation of the Her-2/neu gene amplification status in cytologic breast cancer specimens, particularly in metastatic breast cancer lesions. The advantages of signal permanency and bright-field microscopic result interpretation make this technique an attractive alternative to the current FISH-based gold standard
Improving Performance of Iterative Methods by Lossy Checkponting
Iterative methods are commonly used approaches to solve large, sparse linear
systems, which are fundamental operations for many modern scientific
simulations. When the large-scale iterative methods are running with a large
number of ranks in parallel, they have to checkpoint the dynamic variables
periodically in case of unavoidable fail-stop errors, requiring fast I/O
systems and large storage space. To this end, significantly reducing the
checkpointing overhead is critical to improving the overall performance of
iterative methods. Our contribution is fourfold. (1) We propose a novel lossy
checkpointing scheme that can significantly improve the checkpointing
performance of iterative methods by leveraging lossy compressors. (2) We
formulate a lossy checkpointing performance model and derive theoretically an
upper bound for the extra number of iterations caused by the distortion of data
in lossy checkpoints, in order to guarantee the performance improvement under
the lossy checkpointing scheme. (3) We analyze the impact of lossy
checkpointing (i.e., extra number of iterations caused by lossy checkpointing
files) for multiple types of iterative methods. (4)We evaluate the lossy
checkpointing scheme with optimal checkpointing intervals on a high-performance
computing environment with 2,048 cores, using a well-known scientific
computation package PETSc and a state-of-the-art checkpoint/restart toolkit.
Experiments show that our optimized lossy checkpointing scheme can
significantly reduce the fault tolerance overhead for iterative methods by
23%~70% compared with traditional checkpointing and 20%~58% compared with
lossless-compressed checkpointing, in the presence of system failures.Comment: 14 pages, 10 figures, HPDC'1
Solitary fibrous tumor of the orbit—two cases and a review of the literature
Solitary fibrous tumors of the orbit (SFT) are mesenchymal lesions that can develop either as malignant or benign neoplasias. We describe the histological features leading to the diagnosis in two females and review the current literature. Diagnosis of SFT only can be performed by histological examination, since clinical signs and radiological features are not specific enough. Even a malignant or benign course cannot be predicted, since clinical and radiological features do not correlate with histological signs of malignancy and vice versa. Radical resection is the treatment of choice, since no other treatment option has been proven to be efficien
Bauran Pemasaran Pengaruhnya terhadap Minat Membeli Kembali Voucher Isi Ulang Telkomsel
Perusahaan operator telepon seluler memerlukan cara yang kreatif untuk mempengaruhi keputusan pembelian konsumen. Salah satu strategi dalam memenangkan pasar, yaitu strategi bauran pemasaran atau marketing mix. Penelitian ini bertujuan untuk mengetahui pengaruh produk, promosi, harga dan tempat terhadap Minat Beli ulang Voucher Telkomsel pada Mahasiswa Fakultas Ekonomi dan Bisnis (FEB) Universitas Sam Ratulangi di kota Manado, penelitian ini menggunakan Metode asosiatif dengan teknik Analisis Regresi Linear Berganda dan sampel berjumlah 100 orang menggunakan teknik pengambilan sampel Slovin. Hasil analisis diperoleh bahwa produk, promosi, harga dan tempat berpengaruh positif baik secara simultan maupun parsial terhadap keputusan pembelian ulang vouher isi ulang Telkomsel. Untuk meningkatkan kepuasan konsumen hendaknya pihak manajemen memberikan perhatian pada promosi dan harga sehingga dapat meningkatkan minat membeli ulang dari konsumen Kata kunci: produk, promosi, harga, tempat, keputusan pembelian ulan
Evolution of the Cluster Correlation Function
We study the evolution of the cluster correlation function and its
richness-dependence from z = 0 to z = 3 using large-scale cosmological
simulations. A standard flat LCDM model with \Omega_m = 0.3 and, for
comparison, a tilted \Omega_m = 1 model, TSCDM, are used. The evolutionary
predictions are presented in a format suitable for direct comparisons with
observations. We find that the cluster correlation strength increases with
redshift: high redshift clusters are clustered more strongly (in comoving
scale) than low redshift clusters of the same mass. The increased correlations
with redshift, in spite of the decreasing mass correlation strength, is caused
by the strong increase in cluster bias with redshift: clusters represent higher
density peaks of the mass distribution as the redshift increases. The
richness-dependent cluster correlation function, presented as the
correlation-scale versus cluster mean separation relation, R_0 - d, is found to
be, remarkably, independent of redshift to z <~ 2 for LCDM and z <~ 1 for TCDM
(for a fixed correlation function slope and cluster mass within a fixed
comoving radius). The non-evolving R_0 - d relation implies that both the
comoving clustering scale and the cluster mean separation increase with
redshift for the same mass clusters so that the R_0 - d relation remains
essentially unchanged. The evolution of the R_0 - d relation from z ~ 0 to z ~
3 provides an important new tool in cosmology; it can be used to break
degeneracies that exist at z ~ 0 and provide precise determination of
cosmological parameters.Comment: AASTeX, 15 pages, including 5 figures, accepted version for
publication in ApJ, vol.603, March 200
Binary Black-Hole Mergers in Magnetized Disks: Simulations in Full General Relativity
We present results from the first fully general relativistic,
magnetohydrodynamic (GRMHD) simulations of an equal-mass black hole binary
(BHBH) in a magnetized, circumbinary accretion disk. We simulate both the pre
and post-decoupling phases of a BHBH-disk system and both "cooling" and
"no-cooling" gas flows. Prior to decoupling, the competition between the binary
tidal torques and the effective viscous torques due to MHD turbulence depletes
the disk interior to the binary orbit. However, it also induces a two-stream
accretion flow and mildly relativistic polar outflows from the BHs. Following
decoupling, but before gas fills the low-density "hollow" surrounding the
remnant, the accretion rate is reduced, while there is a prompt electromagnetic
(EM) luminosity enhancement following merger due to shock heating and accretion
onto the spinning BH remnant. This investigation, though preliminary, previews
more detailed GRMHD simulations we plan to perform in anticipation of future,
simultaneous detections of gravitational and EM radiation from a merging
BHBH-disk system.Comment: 5 pages, 5 figure
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