Risk of superior gluteal nerve injury after using ante-grade femoral nailing

Antegrade intramedullary femoral nailing (AIFN) is used as the preferred treatment for diaphyseal and subtrochanteric femur fractures. Nevertheless, clinically important complications associated with obtaining nail entry including loss of hip abductor strength, chronic hip pain, heterotopic ossification and femoral head osteonecrosis have been previously shown.This study was aimed to evaluate the risk of injury to the superior gluteal nerve when Ante-grade femoral nailing is used for insertion. In current study, 25 patients with femoral shaft fractures were included in this study that 21 were male with an average age of 25.40 years, Also 4 cases were female with an average age of 28.20 years. The patients were between the ages of 93 to 05 years. EMG-MCV was taken from all patients and were reported by neurologist. Plain radiographs were taken from all patients. Pain intensity of patients in the last month were identified from 4 to 944 according to the patients statements. The frequency of patients with subjective lameness separately with or no signs was determined. In terms of the pain score, its average among all patients was calculated to be 4.92, while the average of 4.75 among men was calculated. Among women, the average was 5.60. All patients had a mean duration of 3.64 months for using crutches, that the average duration of 3.80 months for men and 3 months for women were calculated.In terms of subjective limping, 15 patients (60) complained from limping, while 10 people were not affected (40 ), of which, 12 patients (80) was belonged to men group and 3 patients (20) were assigned in women group. 5 patients were diagnosed with atrophy of gluteus medius and gluteus minimus muscles that, 3 patients were male (60) and 2 cases (40) were women respectively. EMG-NCV indicated that the Superior gluteal nerve injury had occurred in 2 patients (8) and myogenic damage of gluteus medius and gluteus minimus muscles in 5 patients (20). Our study indicated that the superior gluteal nerve injury had occurred in 2 8 of patients and myogenic damage of gluteus medius and gluteus minimus muscles in 20

Evaluation of inflammatory response in patients undergoing surgical treatment for early and delayed femoral fractures

Introduction: It has been shown that long bone fractures are correlated with the inflammatory response. In the initial injury, surgical reduction and fixation of fractures induce the immunoinflammatory response. This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. Material and methods: This study aimed to evaluate serum variation of inflammatory markers in patients undergoing surgical treatment for early and delayed femoral fractures. The patients were randomly divided into two groups using the method of block randomization including early surgery (within 24 h) and delayed surgery (after 48 h). Serum levels of inflammatory markers in both groups including interleukin (IL)-1, 5, 6, tumor necrosis factor α (TNF-α) and interferon γ (IFN-γ) were determined using specific kits. From each patient 10 ml blood was collected for cytokine assay in their serum. Results: Our findings suggest that serum levels of IL-8 were markedly decreased from 12 h until 48 h postoperatively (p < 0.05). Moreover, the results indicated that serum levels of TNF-α were significantly increased in the early hours, but after 48 h a decreasing trend was detected (p < 0.05). Furthermore, serum levels of IL-10, IFN-γ, and IL-6 were significantly increased from 12 h until 48 h postoperatively (p < 0.05). Conclusions: The inflammatory status of the patient may be a useful adjunct in clinical decisions. With an improved understanding of the molecular basis of the inflammatory response, and by identifying relevant clinical markers of inflammation, surgeons can better manage the timing of surgical stabilization. © 2016 Termedia & Banach

Extended vertical trapezius fasciocutaneous flap (back flap) in face and neck burn scar reconstruction

Elevation of the skin along with its deep fascia vascular network is a recent facility for flap design. The longitudinal trapezius fasciocutaneous flap was first introduced in 1996; at that time it did not receive much attention, although it has many significant benefits compared with other available procedures.Sixteen trapezius fasciocutaneous flaps were elevated in 15 patients for reconstruction of severe scarring of the neck and midface. All flaps were based on the deep branch of the transverse cervical artery and included the overlying fascia of the trapezius muscle. Delaying was applied for very long flaps. Two flaps developed minimal distal necrosis (10 cm below the muscle border). The results indicate that an extra-long back fascia flap based on the descending branch of the transverse cervical artery could be formed, which would be long enough to reconstruct the entire neck and safely transfer it to the midface.The vertical trapezius fasciocutaneous flap, with its abundant tissue, excellent blood supply, anatomic proximity, wide arc of rotation, and hidden donor site scar, provides a simple and reliable method for primary reconstruction of various midface and neck defects. Copyright © 2008 by Lippincott Williams & Wilkins

Extended vertical trapezius fasciocutaneous flap (back flap) in face and neck burn scar reconstruction

Elevation of the skin along with its deep fascia vascular network is a recent facility for flap design. The longitudinal trapezius fasciocutaneous flap was first introduced in 1996; at that time it did not receive much attention, although it has many significant benefits compared with other available procedures.Sixteen trapezius fasciocutaneous flaps were elevated in 15 patients for reconstruction of severe scarring of the neck and midface. All flaps were based on the deep branch of the transverse cervical artery and included the overlying fascia of the trapezius muscle. Delaying was applied for very long flaps. Two flaps developed minimal distal necrosis (10 cm below the muscle border). The results indicate that an extra-long back fascia flap based on the descending branch of the transverse cervical artery could be formed, which would be long enough to reconstruct the entire neck and safely transfer it to the midface.The vertical trapezius fasciocutaneous flap, with its abundant tissue, excellent blood supply, anatomic proximity, wide arc of rotation, and hidden donor site scar, provides a simple and reliable method for primary reconstruction of various midface and neck defects. Copyright © 2008 by Lippincott Williams & Wilkins

MicroRNAs signatures, bioinformatics analysis of miRNAs, miRNA mimics and antagonists, and miRNA therapeutics in osteosarcoma

MicroRNAs (miRNAs) involved in key signaling pathways and aggressive phenotypes of osteosarcoma (OS) was discussed, including PI3K/AKT/MTOR, MTOR AND RAF-1 signaling, tumor suppressor P53- linked miRNAs, NOTCH- related miRNAs, miRNA -15/16 cluster, apoptosis related miRNAs, invasion-metastasis-related miRNAs, and 14Q32-associated miRNAs cluster. Herrin, we discussed insights into the targeted therapies including miRNAs (i.e., tumor-suppressive miRNAs and oncomiRNAs). Using bioinformatics tools, the interaction network of all OS-associated miRNAs and their targets was also depicted. © 2020 The Author(s)