Investigation of the Impacts of Effective Fuel Cost Increase on the US Air Transportation Network and Fleet

The cost of aviation fuel increased 244% between July 2004 and July 2008, becoming the largest operating cost item for airlines. Given the potential for future increases in crude oil prices, as well as environmental costs (i.e. from cap and trade schemes or taxes), the effective cost of aviation fuel may continue to increase, further impacting airlines’ financial performance and the provision of air service nationwide. We evaluate how fuel price increase and volatility affected continental US air transportation networks and fleets in the short- and medium-term using the increase in the 2007-08 and 2004-08 periods as a natural experiment. It was found that non-hub airports serving small communities lost 12% of connections, compared to an average loss of 2.8%, July 2004-08. It is believed that reduced access to the national air transportation system had social and economic impacts for small communities. Complementary analyses of aircraft fuel efficiency, airline economics, and airfares provided a basis for understanding some airline decisions. Increased effective fuel costs will provide incentives for airlines to improve fleet fuel efficiency, reducing the environmental effects of aviation, but may cause an uneven distribution of social and economic impacts as airline networks adapt. Government action may be required to determine acceptable levels of access to service as the air transportation system transitions to higher fuel costs.The authors would like to thank the MIT Partnership on AiR Transportation Noise & Emissions Reduction (PARTNER) for access to the Piano-X software package and Brian Yutko for his assistance in its use. This work was supported by the MIT/Masdar Institute of Science and Technology under grant number Mubadala Development Co. Agreement 12/1/06

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Competencies of an entry-level career counsellor in higher education

This applied research addressed the issue of competencies for entry-level practitioners in the profession of career counselling. It specifically addressed those competencies required for the industry sector of higher education, as distinct from general career counselling and that used in school settings. The research found that there has been progress toward documentation and agreement on competencies for career counsellors. However, there has been only limited work specific to the higher education sector. A survey of industry professionals was used to determine the status of 28 proposed competencies that were drawn from previous research using a nominal group method. The results indicate overwhelming endorsement of the majority of the competencies. Further research is required to enhance validity of the survey results and to begin work on the detail of performance criteria and elements underpinning the competencies

A charge coupled device television camera based system for imaging the distribution of OH in flames

SIGLEAvailable from British Library Document Supply Centre- DSC:7761.039(RD/M--1753/R88) / BLDSC - British Library Document Supply CentreGBUnited Kingdo