1,270 research outputs found
Role of new drug therapies and innovative procedures in older patients with heart failure: from trials to clinical practice
Severe aortic stenosis and transcatheter aortic valve replacement in elderly patients: utility vs futility
The Changing Landscape for Stroke Prevention in AF: Findings From the GLORIA-AF Registry Phase 2
Prevalence and correlates of frailty in older hypertensive outpatients according to different tools: the HYPER-FRAIL pilot study
Positive effects of aerobic physical activity in institutionalized older subjects complaining of dyspnea
Impact of frailty models on the prescription of oral anticoagulants and on the incidence of stroke, bleeding, and mortality in older patients with atrial fibrillation: a systematic review
Oral anticoagulant therapy in atrial fibrillation older patients with previous bleeding
Oral anticoagulant therapy (OAT) with direct oral anticoagulant (DOACs) is the established treatment to reduce thromboembolic risk in patients with atrial fibrillation (AF). Bleeding risk scores are useful to identify and correct factors associated with bleeding risk in AF patients on OAT. However, the clinical scenario is more complex in patients with previous bleeding event, and the decision about whether and when starting or re-starting OAT in these patients remains a contentious issue. Major bleeding is associated with a subsequent increase in both short- and long-term mortality, and even minimal bleeding may have prognostic importance because it frequently leads to disruption of antithrombotic therapy. There is an unmet need for guidance on how to manage antithrombotic therapy after bleeding has occurred. While waiting for observational and randomized data to accrue, this paper offers a perspective on managing antithrombotic therapy after bleeding in older patients with AF
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