The Influence of Chronotype and Grit on Lifestyle and Physical Activity

Background:  The chronotype of a person refers to an individual's natural sleep-wake cycle and whether that individual prefers morning or evening activities, and grit is an individual's perseverance and passion for long-term goals.Aim: The purpose of this study was to investigate the relationship between grit, chronotype, physical activity, and leading a healthy lifestyle in college-age students.Methods:  Health and fitness data (i.e., chronotype, grit, lifestyle assessment score, and daily steps) from 431 first-semester university students at a private college were collected and analyzed. Results: This study found that grit and chronotype both have significant correlations with living a healthy lifestyle and with physical activity. Grit more accurately predicts a person's lifestyle (β = -13.712, r = 0.39, p < 0.0001) while chronotype more accurately predicts the physical activity, or steps, of a person (β = 66.48, r = .19, p = .0001). Chronotype can also accurately predict the grit of a person (r = .25, p < .0001), and it was found that morning people tend to have more grit.Conclusions:  This study concluded that grit, chronotype, steps, and a healthy lifestyle are all significantly correlated with each other. Knowing the relationship between endogenous chronotype, grit, and living a physically active and healthy lifestyle can help inform policy decisions related to the goal of strengthening an institution's inclusive and healthy academic community

The Impact of the COVID-19 Pandemic on College Student’s Stress and Physical Activity Levels

Background: The coronavirus disease 2019 (COVID-19) pandemic adversely disrupted university student educational experiences worldwide, with consequences that included increased stress levels and unhealthy sedentary behavior. Aim: This study aimed to quantify the degree of impact that COVID-19 had on the levels of physical activity and stress of university students by utilizing wearable fitness tracker data and standard stress survey instrument scores before and during the pandemic. Methods: We collected Fitbit heart rate and physical activity data, and the results of a modified Social Readjustment Rating Scale (SRRS) stress survey from 2,987 university students during the Fall 2019 (residential instruction; before COVID-19) and Fall 2020 (hybrid instruction; during COVID-19) semesters. Results: We found indicators of increased sedentary behavior during the pandemic. There was a significant decrease in both the levels of physical activity as measured by mean daily step count (↓636 steps/day; p = 1.04 · 10-9) and minutes spent in various heart rate zones (↓58 minutes/week; p = 2.20 · 10-16). We also found an increase in stressors during the pandemic, primarily from an increase in the number of students who experienced the “death of a close family member” (38.8%), with the number even higher for the population of students who opted to stay home and attend classes virtually (41.4%). Conclusions: This study quantifies the decrease in levels of physical activity and notes an increase in the number of students who experienced the death of a close family member, a known stressor, during the first year of the COVID-19 pandemic. These findings allow for more informed student-health-focused interventions related to the COVID-19 pandemic disruptions experienced by academic communities worldwide

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Alcohol Pharmacology Education Partnership: Using Chemistry and Biology Concepts To Educate High School Students about Alcohol

We developed the Alcohol Pharmacology Education Partnership (APEP), a set of modules designed to integrate a topic of interest (alcohol) with concepts in chemistry and biology for high school students. Chemistry and biology teachers (<i>n</i> = 156) were recruited nationally to field-test APEP in a controlled study. Teachers obtained professional development either at a conference-based workshop (NSTA or NCSTA) or via distance learning to learn how to incorporate the APEP modules into their teaching. They field-tested the modules in their classes during the following year. Teacher knowledge of chemistry and biology concepts increased significantly following professional development, and was maintained for at least a year. Their students (<i>n</i> = 14 014) demonstrated significantly higher scores when assessed for knowledge of both basic and advanced chemistry and biology concepts compared to students not using APEP modules in their classes the previous year. Higher scores were achieved as the number of modules used increased. These findings are consistent with our previous studies, demonstrating higher scores in chemistry and biology after students use modules that integrate topics interesting to them, such as drugs (the Pharmacology Education Partnership)

Soul behind the skill, heart behind the technique: experiences of flow among artistically talented students in Singapore

Case studies of students enrolled in a specialized secondary school in Singapore describe the experiences of flow among 14 teacher-nominated adolescents talented both in the arts and in academics. Individual in-depth interviews were conducted with the respondents to discern whether they experience flow as they each engage in their respective art forms (visual arts, dance, music, and theater). Qualitative analysis of the interview transcripts reveals elements of the flow state (clear goals, intense concentration, enjoyment, loss of self-consciousness, transformation of time) highly evident among the talented teenagers. Environmental supports that enable expressions of artistic inclinations and identities within the Singapore context were likewise in conjunction with implications for arts-educators and artist-practitioners