La Cantatrice chauve

La Cantatrice chauve : photo Quenneville, Paris. Une mise en scène filmique La mise en scène de J.-L. Lagarce évoque de façon sensible le dessin animé. Le décor semble issu d’un dessin d’enfant avec des couleurs naïves, un peu acidulées (rose bonbon, vert pomme, jaune fluo...) et une façade de maison telle que l’imaginaire enfantin pourrait se la représenter. Sur scène se créé un réseau dynamique de significations : un songe, par certains aspects, notamment par le choix des couleurs, à Walt D..

Cellulose coating and chelation of antibacterial compounds for the protection of flax yarns against natural soil degradation.

Natural cellulosic fibres such as flax fibres present interesting mechanical properties as well as biodegradability, and by-products, such as short flax fibres, could be used to produce geotextiles to stabilise soils. Today, geotextiles are often made of coir fibres, which have a high lignin percentage leading to their slow degradation in soil. Fibres with a high cellulosic content, such as those of flax, exhibit lower resistance to soil degradation. This study investigates solutions to improve this parameter with a view to increasing their service life and therefore their credibility compared to coir fibres for geotextile applications. For this purpose, a cellulose coating of yarns made of short flax fibres was performed and its stability under a water flow was assessed. The ability to form a cellulose sheath was estimated by chromaticity measurements of flax fibres after applying a dye specific to lignin. Infrared spectrometry analysis to monitor the level of protection against degradation by cellulolytic enzymes was also carried out. It appears that the cellulose coating provides an efficient physical protection, preventing access of these enzymes to their fibrous substrate. Then, the possibility of conferring antibacterial properties on the cellulose coating by chelating phytoalexin molecules such as gramine on it was assayed and proven to be effective against soil cellulolytic bacteria such as Cellvibrio fulvus and Cellvibrio vulgaris. This study therefore establishes that coating flax yarns with cellulose associated with antibacterial molecules could contribute to obtaining a longer service life in soil for geotextiles manufactured from flax fibres

Pharmacogenomics of the efficacy and safety of Colchicine in COLCOT

© 2021 The Authors. Circulation: Genomic and Precision Medicine is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited and is not used for commercial purposes.Background: The randomized, placebo-controlled COLCOT (Colchicine Cardiovascular Outcomes Trial) has shown the benefits of colchicine 0.5 mg daily to lower the rate of ischemic cardiovascular events in patients with a recent myocardial infarction. Here, we conducted a post hoc pharmacogenomic study of COLCOT with the aim to identify genetic predictors of the efficacy and safety of treatment with colchicine. Methods: There were 1522 participants of European ancestry from the COLCOT trial available for the pharmacogenomic study of COLCOT trial. The pharmacogenomic study's primary cardiovascular end point was defined as for the main trial, as time to first occurrence of cardiovascular death, resuscitated cardiac arrest, myocardial infarction, stroke, or urgent hospitalization for angina requiring coronary revascularization. The safety end point was time to the first report of gastrointestinal events. Patients' DNA was genotyped using the Illumina Global Screening array followed by imputation. We performed a genome-wide association study in colchicine-treated patients. Results: None of the genetic variants passed the genome-wide association study significance threshold for the primary cardiovascular end point conducted in 702 patients in the colchicine arm who were compliant to medication. The genome-wide association study for gastrointestinal events was conducted in all 767 patients in the colchicine arm and found 2 significant association signals, one with lead variant rs6916345 (hazard ratio, 1.89 [95% CI, 1.52-2.35], P=7.41×10-9) in a locus which colocalizes with Crohn disease, and one with lead variant rs74795203 (hazard ratio, 2.51 [95% CI, 1.82-3.47]; P=2.70×10-8), an intronic variant in gene SEPHS1. The interaction terms between the genetic variants and treatment with colchicine versus placebo were significant. Conclusions: We found 2 genomic regions associated with gastrointestinal events in patients treated with colchicine. Those findings will benefit from replication to confirm that some patients may have genetic predispositions to lower tolerability of treatment with colchicine.info:eu-repo/semantics/publishedVersio

Christophe Toupet (1953-2012)

Soulier Philippe, Blondeau Céline. Christophe Toupet (1953-2012). In: Bulletin de la Société préhistorique française, tome 110, n°3, 2013. pp. 571-577

Christophe Toupet (1953-2012)

Soulier Philippe, Blondeau Céline. Christophe Toupet (1953-2012). In: Bulletin de la Société préhistorique française, tome 110, n°3, 2013. pp. 571-577

Roald Dahl, la fabrique d'un imaginaire

International audienceRéunit les contributions de : Yannick BELLENGER-MORVAN, Noëlle BENHAMOU, Philippe BLONDEAU, Justine BRETON, Isabelle Rachel CASTA, Florence CASULLI, Virginie DOUGLAS, Béatrice FINET, Yvon HOUSSAIS, Marie-Claude HUBERT, Lydie LAROQUE, Jean-Michel POTTIER, Christine PREVOST

La trousse d'urgence du médecin généraliste (évaluation du contenu et de l'utilisation en zone urbaine et rurale)

CAEN-BU Médecine pharmacie (141182102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Greenhouse humidity control with enthalpy recovery

International audienc