Genetic diversity analysis of varronia curassavica Jacq. accessions using ISSR markers

Varronia curassavica Jacq. is a medicinal and aromatic plant from Brazil with significant economic importance. Studies on genetic diversity in active germplasm banks (AGB) are essential for conservation and breeding programs. The aim of this study was to analyze the genetic diversity of V. curassavica accessions of the AGB of Medicinal and Aromatic Plants of the Federal University of Sergipe (UFS), using inter-simple sequence repeat molecular markers. Twenty-four primers were tested, and 14 were polymorphic and informative, resulting in 149 bands with 97.98% polymorphism. The UPGMA dendrogram divided the accessions into Clusters I and II. Jaccard similarity coefficients for pair-wise comparisons of accessions ranged between 0.24 and 0.78. The pairs of accessions VCUR-001/VCUR-503, VCUR-001/VCUR-504, and VCUR-104/VCUR-501 showed relatively low similarity (0.24), and the pair of accessions VCUR-402/VCUR403 showed medium similarity (0.78). Twenty-eight accessions were divided into three distinct clusters, according to the STRUCTURE analysis. The genetic diversity of V. curassavica in the AGB of UFS is low to medium, and it requires expansion. Accession VCUR-802 is the most suitable for selection in breeding program of this species, since it clearly represents all of the diversity present in the AGB153CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESFINANCIADORA DE ESTUDOS E PROJETOS - FINEPFUNDAÇÃO DE APOIO À PESQUISA E À INOVAÇÃO TECNOLÓGICA DO ESTADO DE SERGIPE - FAPITECnão temnão temnão temnão te

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

Preparation and property studies of new detectors of transuranium elements

The possibility to use porous scintillators based on the organic molecular crystal of p-terphenyl for determination of a-nuclides in the environmental water has been shown. The technological methods of the porous scintillator preparation have been improved. As a selective sorbent for transuranium elements, the strong-basic anion-exchange resin VP- lAp was used. The operation efficiency of the prepared material has been checked using model systems of ²³⁹Pu reference solutions.Показано принципову можливiсть використання пористих сцинтиляторiв на основi органiчного молекулярного кристала n-терфенiлу для визначення a-нуклiдiв у водних об'єктах довкiлля. Удосконалено технологiчнi прийоми виготовлення пористих композитiв. Як селективний до трансуранових елементiв сорбент, використано сильноосновний анiонiт ВП-lап. Дослiдження працездатностi запропонованого матерiалу проведено на модельних системах на основi зразкових радiоактивних розчинiв ²³⁹Pu.Показана возможность применения пористых сцинтилляторов на основе органического молекулярного кристала n-терфенила для определения a-нуклидов в водных объектах окружающей среды. Усовершенствованы технологические приемы изготовления пористых композитов. В качестве селективного к трансурановым элементам сорбента выбран сильноосновный анионит ВП-lап. Исследование работоспособности предлагае мого материала проводилось на модельных системах на основе образцовых радиоактивных растворов ²³⁹Pu

Characterization of epitaxial Pb(Zr,Ti)O3 thin films deposited by pulsed laser deposition on silicon cantilevers

This paper reports on the piezoelectric-microelectromechanical system micro-fabrication process and the behavior of piezoelectric stacks actuated silicon cantilevers. All oxide layers in the piezoelectric stacks, such as buffer-layer/bottom-electrode/film/top-electrode: YSZ/SrRuO3/Pb(Zr,Ti)3/SrRuO3, were grown epitaxially on the Si template of silicon-on-insulator substrates by pulsed laser deposition. By using an analytical model and finite element simulation, the initial bending of the cantilevers was calculated. These theoretical analyses are in good agreement with the experimental results which were determined using a white light interferometer. The dependences of the cantilever displacement, resonance frequency and quality factor on the cantilever geometry have been investigated using a laser-Doppler vibrometer. The tip displacement ranged from 0.03 to 0.42 µm V−1, whereas the resonance frequency and quality factor values changed from 1010 to 18.6 kHz and 614 to 174, respectively, for the cantilevers with lengths in the range of 100–800 µm. Furthermore, the effect of the conductive oxide electrodes on the stability of the piezoelectric displacement of the cantilevers has been studied

Merrifield resin-linked polyazole-based sorbent for heavy metal ions extraction from water

A new sorbent for heavy metal ions, that contains links with fragments of 1,2,3-triazole, 1,2,3- and 1,2,4-triazole, both triazoles and tetrazole was developed and appropriate procedures for the synthesis of these links were described. The obtained polymer is able to form stable complexes with the ions of heavy metals, such as Eu(III), Cd(II), Pb(II), Cu(II), Sr(II). The extraction rate dependence on the age of the sorbent, concentration of the cations, pH, and concentration of competing anions was studied