LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse

Premature ovarian failure and female infertility are frequent side effects of anticancer therapies, owing to the extreme sensitivity of the ovarian reserve oocytes to the damaging effects of irradiation and chemotherapy on DNA. We report here a robust protective effect of luteinizing hormone (LH) on the primordial follicle pool of prepubertal ovaries against the cisplatin (Cs)-induced apoptosis. In vitro LH treatment of prepubertal ovarian fragments generated anti-apoptotic signals by a subset of ovarian somatic cells expressing LH receptor (LHR) through cAMP/PKA and Akt pathways. Such signals, reducing the oocyte level of pro-apoptotic TAp63 protein and favoring the repair of the Cs-damaged DNA in the oocytes, prevented their apoptosis. Noteworthy, in vivo administration to prepubertal female mice of a single dose of LH together with Cs inhibited the depletion of the primordial follicle reserve caused by the drug and preserved their fertility in reproductive age, preventing significant alteration in the number of pregnancy and of delivered pups. In conclusion, these findings establish a novel ovoprotective role for LH and further support the very attracting prospective to use physiological 'fertoprotective' approaches for preventing premature infertility and risks linked to precocious menopause in young patients who survived cancer after chemotherapy

Experimental investigation of the effects of pipe location on the bearing capacity

A series of laboratory model tests were conducted to investigate the effects of buried pipes location on the bearing capacity of strip footing in cohesionless soil. The variables examined in the testing program include relative density of the sand, loading rate of tests, burial depths of pipe and horizontal distance of pipe to footing. The test results showed a significant increase in bearing capacities when embedment ratio of pipe and horizontal distance of pipe to footing were increased. Based on the test results, it can be concluded that the location of pipes and relative density of sand are main parameters that affect the bearing capacity of strip footing. However, loading rate has not considerable effect on bearing capacity. © 2015 Techno-Press, Ltd

Applications of optimal perturbation iteration method for solving nonlinear differential equations

Perturbation iteration method has been recently constructed and it has been also proven that this technique is very effective for solving some nonlinear differential equations. In this study, we develop the new optimal perturbation iteration method based on the perturbation iteration algorithms for the approximate solutions of nonlinear differential equations of many types. This work will greatly improve the computational efficiency of the perturbation iteration method. Applications also show that only a few terms are required to get an approximate solution which is more accurate and efficient than many other methods in literature. © 2017 Author(s)

Comparative Study between Optimal Homotopy Asymptotic Method and Perturbation-Iteration Technique for Different Types of Nonlinear Equations

In this paper, we compare optimal homotopy asymptotic method and perturbation-iteration method to solve random nonlinear differential equations. Both of these methods are known to be new and very powerful for solving differential equations. We give some numerical examples to prove these claims. These illustrations are also used to check the convergence of the proposed methods. © 2016, Shiraz University

MATHEMATICAL METHODS IN THE APPLIED SCIENCES

In this work, the optimal perturbation iteration method is briefly presented and employed for solving nonlinear Volterra-Fredholm integral equations. The classical form of the optimal perturbation iteration method is modified, and new algorithms are constructed for integral equations. Comparing our new algorithms with some earlier papers proved the excellent accuracy of the newly proposed technique

New analytic approximate solutions to the generalized regularized long wave equations

In this paper, the new optimal perturbation iteration method has been applied to solve the generalized regularized long wave equation. Comparing the new analytic approximate solutions with the known exact solutions reveals that the proposed technique is extremely accurate and effective in solving nonlinear wave equations. We also show that, un like many other methods in literature, this method converges rapidly to exact solutions at lower order of approximations. © 2018 Korean Mathematial Soiety