Synthesis of 2‑Aminobenzoxazoles and 3‑Aminobenzoxazines via Palladium-Catalyzed Aerobic Oxidation of <i>o</i>‑Aminophenols with Isocyanides

A Pd-catalyzed aerobic oxidation of <i>o</i>-aminophenols and isocyanides for the synthesis of 2-aminobenzoxazoles and 3-aminobenzoxazines has been achieved in an air atmosphere. The procedure constructs 2-aminobenzoxazoles and 3-aminobenzoxazines with moderate to excellent yields and a broad substrate scope. Apart from experimental simplicity, this methodology has the advantages of mild reaction conditions and easily accessible starting materials. Furthermore, the utility of this method has also been successfully applied to the synthesis of other types of useful nitrogen heterocycles

Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2‑Ethynylanilines with Isocyanides: Regioselective Synthesis of 4‑Halo-2-aminoquinolines

A robust and regioselective palladium-catalyzed intermolecular aerobic oxidative cyclization of 2-ethynylanilines with isocyanides to the synthesis of 4-halo-2-aminoquinolines is reported herein. The procedure constructs various 4-halo-2-aminoquinolines with moderate to excellent yields (47–94%) and broad substrates scope. Furthermore, this process can be easily extended to synthesis of various 6<i>H</i>-indolo­[2,3-<i>b</i>]­quinolines via an intramolecular Buchwald–Hartwig cross-coupling reaction in two-step one-pot manner

Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2‑Ethynylanilines with Isocyanides: Regioselective Synthesis of 4‑Halo-2-aminoquinolines

A robust and regioselective palladium-catalyzed intermolecular aerobic oxidative cyclization of 2-ethynylanilines with isocyanides to the synthesis of 4-halo-2-aminoquinolines is reported herein. The procedure constructs various 4-halo-2-aminoquinolines with moderate to excellent yields (47–94%) and broad substrates scope. Furthermore, this process can be easily extended to synthesis of various 6<i>H</i>-indolo­[2,3-<i>b</i>]­quinolines via an intramolecular Buchwald–Hartwig cross-coupling reaction in two-step one-pot manner

Photodriven Radical Perfluoroalkylation–Thiolation of Unactivated Alkenes Enabled by Electron Donor–Acceptor Complex

A clean and direct three-component radical 1,2-difunctionalization of various alkenes with perfluoroalkyl iodides and thiosulfonates enabled by the electron donor–acceptor complex has been developed under light illumination at room temperature. The approach offers a convenient and environmentally friendly route for the simultaneous incorporation of Csp3–Rf and Csp3–S bonds, affording valuable polyfunctionalized alkane derivatives containing fluorine and sulfur in satisfactory yields. Consequently, this methodology holds significant value and practicality in the field of organic synthesis

Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides

An efficient and convenient palladium-catalyzed cyclization reaction of alkynes with isocyanides is described herein. This protocol allows the practical synthesis of many valuable polysubstituted maleimide derivatives after hydrolysis with a broad scope of substrates and mild reaction conditions. C–C, CO, and C–N bonds were constructed in this transformation with isocyanide serving as both C and N sources

Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides

An efficient and convenient palladium-catalyzed cyclization reaction of alkynes with isocyanides is described herein. This protocol allows the practical synthesis of many valuable polysubstituted maleimide derivatives after hydrolysis with a broad scope of substrates and mild reaction conditions. C–C, CO, and C–N bonds were constructed in this transformation with isocyanide serving as both C and N sources

Synthesis of Polysubstituted 3‑Amino Pyrroles via Palladium-Catalyzed Multicomponent Reaction

A novel approach for the synthesis of polysubstituted 3-amino pyrroles via palladium-catalyzed three-component tandem reaction was developed. The procedure constructs various polysubstituted 3-amino pyrroles with moderate to excellent yields under mild reaction conditions with assembly efficiency, readily available starting materials, and good functional group tolerance. Furthermore, this process was successfully applied to the synthesis of different 3-phenyl-1,4-dihydropyrrolo­[3,2-<i>b</i>]­indole derivatives via an intramolecular Buchwald–Hartwig cross-coupling reaction in two steps