7 research outputs found
Synthesis of 2‑Aminobenzoxazoles and 3‑Aminobenzoxazines via Palladium-Catalyzed Aerobic Oxidation of <i>o</i>‑Aminophenols with Isocyanides
A Pd-catalyzed
aerobic oxidation of <i>o</i>-aminophenols and isocyanides
for the synthesis of 2-aminobenzoxazoles and 3-aminobenzoxazines has
been achieved in an air atmosphere. The procedure constructs 2-aminobenzoxazoles
and 3-aminobenzoxazines with moderate to excellent yields and a broad
substrate scope. Apart from experimental simplicity, this methodology
has the advantages of mild reaction conditions and easily accessible
starting materials. Furthermore, the utility of this method has also
been successfully applied to the synthesis of other types of useful
nitrogen heterocycles
Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2‑Ethynylanilines with Isocyanides: Regioselective Synthesis of 4‑Halo-2-aminoquinolines
A robust
and regioselective palladium-catalyzed intermolecular aerobic oxidative
cyclization of 2-ethynylanilines with isocyanides to the synthesis
of 4-halo-2-aminoquinolines is reported herein. The procedure constructs
various 4-halo-2-aminoquinolines with moderate to excellent yields
(47–94%) and broad substrates scope. Furthermore, this process
can be easily extended to synthesis of various 6<i>H</i>-indoloÂ[2,3-<i>b</i>]Âquinolines via an intramolecular Buchwald–Hartwig
cross-coupling reaction in two-step one-pot manner
Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2‑Ethynylanilines with Isocyanides: Regioselective Synthesis of 4‑Halo-2-aminoquinolines
A robust
and regioselective palladium-catalyzed intermolecular aerobic oxidative
cyclization of 2-ethynylanilines with isocyanides to the synthesis
of 4-halo-2-aminoquinolines is reported herein. The procedure constructs
various 4-halo-2-aminoquinolines with moderate to excellent yields
(47–94%) and broad substrates scope. Furthermore, this process
can be easily extended to synthesis of various 6<i>H</i>-indoloÂ[2,3-<i>b</i>]Âquinolines via an intramolecular Buchwald–Hartwig
cross-coupling reaction in two-step one-pot manner
Photodriven Radical Perfluoroalkylation–Thiolation of Unactivated Alkenes Enabled by Electron Donor–Acceptor Complex
A clean and direct three-component
radical 1,2-difunctionalization
of various alkenes with perfluoroalkyl iodides and thiosulfonates
enabled by the electron donor–acceptor complex has been developed
under light illumination at room temperature. The approach offers
a convenient and environmentally friendly route for the simultaneous
incorporation of Csp3–Rf and Csp3–S bonds, affording valuable polyfunctionalized alkane
derivatives containing fluorine and sulfur in satisfactory yields.
Consequently, this methodology holds significant value and practicality
in the field of organic synthesis
Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides
An efficient and convenient palladium-catalyzed
cyclization reaction
of alkynes with isocyanides is described herein. This protocol allows
the practical synthesis of many valuable polysubstituted maleimide
derivatives after hydrolysis with a broad scope of substrates and
mild reaction conditions. C–C, CO, and C–N bonds
were constructed in this transformation with isocyanide serving as
both C and N sources
Assembly of Polysubstituted Maleimides via Palladium-Catalyzed Cyclization Reaction of Alkynes with Isocyanides
An efficient and convenient palladium-catalyzed
cyclization reaction
of alkynes with isocyanides is described herein. This protocol allows
the practical synthesis of many valuable polysubstituted maleimide
derivatives after hydrolysis with a broad scope of substrates and
mild reaction conditions. C–C, CO, and C–N bonds
were constructed in this transformation with isocyanide serving as
both C and N sources
Synthesis of Polysubstituted 3‑Amino Pyrroles via Palladium-Catalyzed Multicomponent Reaction
A novel approach for the synthesis
of polysubstituted 3-amino pyrroles
via palladium-catalyzed three-component tandem reaction was developed.
The procedure constructs various polysubstituted 3-amino pyrroles
with moderate to excellent yields under mild reaction conditions with
assembly efficiency, readily available starting materials, and good
functional group tolerance. Furthermore, this process was successfully
applied to the synthesis of different 3-phenyl-1,4-dihydropyrroloÂ[3,2-<i>b</i>]Âindole derivatives via an intramolecular Buchwald–Hartwig
cross-coupling reaction in two steps