3 research outputs found
Cavernous hemangioma of pancreas
Niez艂o艣liwe nowotwory nie s膮 zmianami cz臋sto stwierdzanymi w trzustce. Guzami, kt贸re najcz臋艣ciej spotyka
si臋 w tym narz膮dzie, s膮 raki. Naczyniaki o tej lokalizacji nale偶膮 do rzadko艣ci.
W niniejszej pracy przedstawiono przypadek pacjenta, kt贸rego przyj臋to na oddzia艂 chirurgii w celu planowej
operacji odtworzenia ci膮g艂o艣ci jelita grubego. Podczas diagnostyki stwierdzono du偶ego guza trzustki.
W zwi膮zku z tym w trakcie laparotomii wykonano pankreatoduodenektomi臋. Badanie histopatologiczne
usuni臋tego guza ujawni艂o niez艂o艣liwy nowotw贸r naczyniowy.
Naczyniaki trzustki nie s膮 cz臋sto spotykane, mog膮 one jednak towarzyszy膰 zmianom zlokalizowanym
w innych narz膮dach. Izolowane naczyniaki trzustki nale偶膮 do rzadko艣ci. Zmiany o niewielkich rozmiarach
zazwyczaj nie wywo艂uj膮 dolegliwo艣ci. Wi臋ksze zmiany mog膮 wywo艂ywa膰 objawy ze strony s膮siednich
narz膮d贸w na skutek ich ucisku, co cz臋sto prowadzi do wykrycia choroby.Benign tumours of the pancreas are unusual pathologies of this organ. The most frequently encountered
tumours of the pancreas are carcinomas. Haemangiomas in this location are rare.
We present here a patient, admitted to the surgical ward for an elective large bowel operation, who,
during preoperative investigations, was diagnosed with a large tumour of the pancreas. During a laparotomy,
a pancreatoduodenectomy was performed, and a histological examination revealed the benign
nature of the tumour.
Despite their infrequent occurrence, haemangiomas of the pancreas may be associated with similar
lesions in other organs. An isolated pancreatic angioma is a rarity. Small lesions usually stay asymptomatic.
Bigger ones may cause symptoms e.g. because of compression of adjacent structures that leads to
the disclosure of the disease
Mutations in the von Hippel-Lindau Tumour Suppressor Gene in Central Nervous System Hemangioblastomas
Central nervous system hemangioblastomas (cHAB) are rare tumours which most commonly arise in the cerebellum. Most tumours are sporadic, but as many as one third of cHABs occur in the course of the hereditary disorder - von Hippel-Lindau disease (VHL). In order to diagnose new VHL families in Poland we performed sequencing of the entire VHL gene in archival material (paraffin embedded hemangioblastoma tissues) in a large series of 203 unselected patients with cHAB. VHL gene mutations were detected in 70 (41%) of 171 tumour samples from which DNA of relatively good quality was isolated. We were able to obtain blood samples from 19 of mutation positive cases. Eight (42%) of these harboured germline mutations in persons from distinct undiagnosed VHL families