6 research outputs found
Formation of a gold-carbon dot nanocomposite with superior catalytic ability for the reduction of aromatic nitro groups in water
We report the synthesis of a gold-carbon dot nanocomposite and its utility as a recyclable catalyst for the reduction of aromatic nitro groups. The presence of carbon dots on gold nanosurfaces enhanced the reduction rate by two-fold
Fabrication of a Vitamin B12-Loaded Carbon Dot/Mixed-Ligand Metal Organic Framework Encapsulated within the Gelatin Microsphere for pH Sensing and In Vitro Wound Healing Assessment
Bacterial invasion is a serious concern during the wound
healing
process. The colonization of bacteria is mainly responsible for the
pH fluctuation at the wound site. Therefore, the fabrication of a
proper wound dressing material with antibacterial activity and pH
monitoring ability is necessary to acquire a fast healing process.
Therefore, this work is dedicated to designing a vitamin B12-loaded
gelatin microsphere (MS) decorated with a carbon dot (CD) metal–organic
framework (MOF) for simultaneous pH sensing and advanced wound closure
application. The resultant MS portrayed a high specific surface area
and a hierarchically porous structure. Furthermore, the surface of
the resultant MS contained numerous carboxyl groups and amine groups
whose deprotonation and protonation with the pH alternation are accountable
for the pH-sensitive properties. The vitamin B12 release study was
speedy from the MOF structure in an acidic medium, which was checked
by gelatin coating, and a controlled drug release behavior was observed.
The system showed excellent cytocompatibility toward the L929 cell
line and remarkable antibacterial performance against Gram-negative Escherichia coli and Gram-positive Staphylococcus aureus. Furthermore, the combined
effect of Zn2+, the imidazole unit, and CDs produces an
outstanding bactericidal effect on the injury sites. Finally, the
in vitro wound model suggests that the presence of the vitamin B12-loaded
gelatin MS accelerates the proliferation of resident fibroblast L929
cells and causes tissue regeneration in a time-dependent manner. The
relative wound area, % of wound closure, and wound healing speed values
are remarkable and suggest the requirement for assessing the response
of the system before exploiting its prospective in vivo application