Random Graphs and Probability Models

Preliminary results concerning random graphs, digraphs, time dependent processes, and probability model

Geotechnical Problems and Performance Studies - Chilla Power Scheme, Hardwar

Thin plastic clay seams existing in the upper Shivalik formations caused hazardous geotechnical problems during the construction of 144 MW capacity Chilla Power House Scheme, Hardwar, India by initiating several land slides. In addition, serious seepage problems occurred with the commissioning of the scheme. The paper describes in detail, the events of slides & seepage problems faced and the remedial measures adopted to counteract them. The data observed on the instruments installed to keep a vigil on the performance of the structure has also been analysed and discussed

Worldwide variations in EGFR somatic mutations: a challenge for personalized medicine

Two studies recently reported around 10% of EGFR activating mutations in triple negative breast cancers from Asian patients. However, we did not find any EGFR activating mutation in a series of 229 breast tumor samples from European patients. Like in lung cancer, the EGFR mutation profiles seem to be related to the ethnical origin of patients. This is an important point that should be considered when developing anti-EGFR therapies

A paper based graphene-nanocauliflower hybrid composite for point of care biosensing

Graphene paper has diverse applications in printed circuit board electronics, bioassays, 3D cell culture, and biosensing. Although development of nanometal-graphene hybrid composites is commonplace in the sensing literature, to date there are only a few examples of nanometal-decorated graphene paper for use in biosensing. In this manuscript, we demonstrate the synthesis and application of Pt nano cauliflower-functionalized graphene paper for use in electrochemical biosensing of small molecules (glucose, acetone, methanol) or detection of pathogenic bacteria (Escherichia coli O157:H7). Raman spectroscopy, scanning electron microscopy and energy dispersive spectroscopy were used to show that graphene oxide deposited on nanocellulose crystals was partially reduced by both thermal and chemical treatment. Fractal platinum nanostructures were formed on the reduced graphene oxide paper, producing a conductive paper with an extremely high electroactive surface area, confirmed by cyclic voltammetry and electrochemical impedance spectroscopy. To show the broad applicability of the material, the platinum surface was functionalized with three different biomaterials: 1) glucose oxidase (via chitosan encapsulation); 2) a DNA aptamer (via covalent linking), or 3) a chemosensory protein (via his linking). We demonstrate the application of this device for point of care biosensing. The detection limit for both glucose (0.08 ± 0.02 μM) and E. coli O157:H7 (1.3 ± 0.1 CFU mL-1) were competitive with, or superior to, previously reported devices in the biosensing literature. The response time (6 sec for glucose and 10 min for E. coli) were also similar to silicon biochip and commercial electrode sensors. The results demonstrate that the nanocellulose-graphene-nanoplatinum material is an excellent paper-based platform for development of electrochemical biosensors targeting small molecules or whole cells for use in point of care biosensing

Making Sense of Metrics in the Music Industries

This article considers how media workers and organizations make use of the abundance of metrics available in the contemporary online environment. The expansion of audience measurement on digital music platforms, dashboard analytics, and third-party providers raises broad societal concerns about the quantification of culture; however, less attention has been paid to how professionals in the music industries approach, understand, and deploy these metrics in their work. Drawing on survey and interview data, we found that music workers do not take metrics on faith or reject them out of hand; rather, they make sense of them, deploy them strategically, and narrate their meanings to give themselves rationales to make investments and predictions and to persuade others to do so

Logarithmic perturbation theory for radial Klein-Gordon equation with screened Coulomb potentials via ℏ\hbar expansions

The explicit semiclassical treatment of logarithmic perturbation theory for the bound-state problem within the framework of the radial Klein-Gordon equation with attractive real-analytic screened Coulomb potentials, contained time-component of a Lorentz four-vector and a Lorentz-scalar term, is developed. Based upon $\hbar$-expansions and suitable quantization conditions a new procedure for deriving perturbation expansions is offered. Avoiding disadvantages of the standard approach, new handy recursion formulae with the same simple form both for ground and excited states have been obtained. As an example, the perturbation expansions for the energy eigenvalues for the Hulth\'en potential containing the vector part as well as the scalar component are considered.Comment: 14 pages, to be submitted to Journal of Physics