967 research outputs found
Deflections in Magnet Fringe Fields
A transverse multipole expansion is derived, including the longitudinal
components necessarily present in regions of varying magnetic field profile. It
can be used for exact numerical orbit following through the fringe field
regions of magnets whose end designs introduce no extraneous components, {\it
i.e.} fields not required to be present by Maxwell's equations. Analytic
evaluations of the deflections are obtained in various approximations. Mainly
emphasized is a ``straight-line approximation'', in which particle orbits are
treated as straight lines through the fringe field regions. This approximation
leads to a readily-evaluated figure of merit, the ratio of r.m.s. end
deflection to nominal body deflection, that can be used to determine whether or
not a fringe field can be neglected. Deflections in ``critical'' cases (e.g.
near intersection regions) are analysed in the same approximation.Comment: To be published in Physical Review
Playback of ultrasonic vocalizations in rats: habituation, response calls, and drug effects
Rats are highly social animals. They have developed a variety of social behaviors including
communication via so-called ultrasonic vocalizations (USV). Among these USV, two types can be
distinguished in juvenile and adult rats. Appetitive 50-kHz USV are thought to represent a positive
affective state, whereas aversive 22-kHz USV are supposed to depict a negative affective state.
Playback of positive 50-kHz USV induces an approach behavior in rats as seen by their approach
behavior to the sound source. Previous studies have shown that this behavior is only detectable
during the first presentation, whereas a quick habituation towards 50-kHz USV results in the rats
not approaching the 50-kHz USV playback a second time, even after several days. This habituation
phenomenon seems to rely on learning and memory mechanisms. However, its underlying
mechanisms have been studied scarcely so far. This dissertation revealed three factors influencing
the habituation phenomenon. First, habituation was dependent on stocks. It was only present in
Wistar but not Sprague-Dawley rats. Second, habituation could be prevented with treatment of
the dopaminergic agonist d-amphetamine before the second 50-kHz USV playback. Third,
habituation was state-dependent. It was shown that when the pharmacologically induced internal
state changed between the two playbacks, no habituation occurred.
Furthermore, the reciprocal nature of USV was investigated in this dissertation. Calls in response
towards 50-kHz USV playback had been reported before, but this dissertation is the first to
characterize response calls. We showed that response calls towards 50-kHz playback are around
frequencies of 30 kHz, have a rather short duration of 0.3 s and hardly any frequency modulation.
These parameters resemble aversive 22-kHz calls, which are unlikely to be found in an appetitive
paradigm as the 50-kHz USV playback. Feasible functions of these response calls might be a
frustrated state due to expectation violation after playback, appeasement calls to pacify the
potential play partner indicated by the playback, or they might serve as social contact calls to
establish proximity.
Taken together, the findings of this dissertation shed light on the reciprocal nature of USV
communication indicated by response calls towards 50-kHz USV playback and present possible
mechanisms how to overcome the habituation phenomenon. This provides tools to further
investigate neurodevelopmental disorders where communication and social behavior is impaired,
such as autism spectrum disorder or the Angelman Syndrome, as well as affective disorders
Cryopreservation of Hematopoietic and Non-Hematopoietic Stem Cells â A Review for the Clinician
Long term nonlinear propagation of uncertainties in perturbed geocentric dynamics using automatic domain splitting
Current approaches to uncertainty propagation in astrodynamics mainly refer tolinearized models or Monte Carlo simulations. Naive linear methods fail in nonlinear dynamics, whereas Monte Carlo simulations tend to be computationallyintensive. Differential algebra has already proven to be an efficient compromiseby replacing thousands of pointwise integrations of Monte Carlo runs with thefast evaluation of the arbitrary order Taylor expansion of the flow of the dynamics. However, the current implementation of the DA-based high-order uncertainty propagator fails in highly nonlinear dynamics or long term propagation. We solve this issue by introducing automatic domain splitting. During propagation, the polynomial of the current state is split in two polynomials when its accuracy reaches a given threshold. The resulting polynomials accurately track uncertainties, even in highly nonlinear dynamics and long term propagations. Furthermore, valuable additional information about the dynamical system is available from the pattern in which those automatic splits occur. From this pattern it is immediately visible where the system behaves chaotically and where its evolution is smooth. Furthermore, it is possible to deduce the behavior of the system for each region, yielding further insight into the dynamics. In this work, the method is applied to the analysis of an end-of-life disposal trajectory of the INTEGRAL spacecraft
A Practical Way Forward for Aviation Multi-Constellation Service Provision based on the ICAO GNSS Charter
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