Köpeklerde intrakranial tümörlerin manyetik rezonans görüntüleme bulguları: 26 olgu

Bu çalışmanın amacı 26 köpekte rastlanan intrakranial tümörün manyetik rezonans görüntüleme (MRG) bulgularını sunmaktır. Kasım 1997- Haziran 2006 tarihleri arasında Ankara Üniversitesi Veteriner Fakültesi Cerrahi Anabilim Dalına merkezi sinir sistemi hastalığı nedeniyle getirilen ve MRG ile intrakranial tümör tanısı konulan köpekler çalışma kapsamına alındı. Manyetik rezonans görüntüleri, T1 ağırlıklı (T1W), T2 ağırlıklı (T2W) ve kontrastlı T1 ağırlıklı (GD-DTPA uygulaması sonrasında) transversal, koronal ve sagittal kesitler şeklinde alındı. Köken aldığı bölge, anatomik lokalizasyon, T1W ve T2W görüntülerdeki sinyal karakteristiği, kontrast artışı, şekli ve boyutları, sayısı (tek veya çok), ödemin varlığı ve yer değiştirme gibi özellikler, lezyonun karakterini belirlemek ve radyolojik bulgulara göre tanı koyabilmek için incelendi. Radyolojik tanıya göre intrakraniale invaze sinus tümörü (n 3), meningioma (n 7), kroid pleksus tümörü veya ependimoma (n 3), ependimoma (n 1), glioma (n 5), metastatik tümör (n 3), astrostoma (n 1), astrostoma veya metastaz (n 1), kavernoma (n 1) ve hipofiz adenoma (n 1) belirlendi. Sonuç olarak, MRG ile intrakranial kitlelerin tam olarak tespit edilebileceği ve tümör tipinin tahmin edilebileceği belirlendi.The aim of this study was to report the magnetic resonance imaging (MRI) findings of intracranial tumors in 26 dogs. The medical records of dogs admitted to the Department of Surgery, Faculty of Veterinary Medicine, Ankara University for central nervous system disorders were reviewed, and dogs with intracranial tumors that were diagnosed with MRI between November 1997 and June 2006 were included in the study. MR images were obtained as T1 weighted (T1W), T2 weighted (T2W), and contrast enhanced T1 weighted (following Gd-DTPA administration) in the transverse, coronal (dorsal), and sagittal planes. The following features were evaluated in order to characterize the lesions and to establish diagnoses based on radiological findings: site of origin, anatomic location, signal characteristics on T1W and T2W images, contrast enhancement, shape and size, number (multiple or single), and presence of edema and midline shift. The radiological diagnoses were as follows: intracranially invading sinus tumor (n 3), meningioma (n 7), choroid plexus tumor or ependymoma (n 3), ependymoma (n 1), glioma (n 5), metastatic tumor (n 3), astrocytoma (n 1), astrocytoma or metastasis (n 1), cavernoma (n 1), and hypophyseal adenoma (n 1). In conclusion, lesions occupying the intracranial space can be accurately diagnosed and tumor type can be predicted with MRI

Effects of methotrexate in a toluene diisocyanate-induced allergic rhinitis rat model

Objectives: This study aims to investigate the therapeutic effect of low-dose topical administration of methotrexate (MTX) in a toluene diisocyanate (TDI)-induced allergic rhinitis rat model. Materials and Methods: The experiments were performed on 18 healthy male Wistar albino rats weighing between 250-270 g. Rats were divided into four study groups: control group (n=5), sham group (n=3), steroid group (n=5), and MTX group (n=5). After the drugs were administered, multiple biopsies were taken bilaterally from the nasal mucosal areas and evaluated histologically for fibrosis, loss of cilia and goblet cells, edema, squamous cell metaplasia, and vascular proliferation. Results: Fibrosis, loss of cilia cells, edema, and vascular proliferation were significantly lower in both MTX and steroid groups than in the control group (p0.05). There were no statistically significant differences with respect to loss of goblet cells and squamous cell metaplasia among the studied groups (p>0.05). Conclusion: Methotrexate may be an alternative or adjuvant therapeutic agent in allergic rhinitis