Use of Articulated Transport Systems in the Mining Industry

The work is devoted to the possibility and prospects of the use of all-wheels drive articulated transport systems in the mining complex. A comparative analysis of the traditional methods of exporting minerals in open pit mining and the method of using active trailed elements are given. The trailer has a load factor several times higher than the same rate for mining dump trucks. The use of an active trailer makes it possible to reduce the mass of the tractor and trailer by almost 40 tons and increase the specific power of the road train. © Published under licence by IOP Publishing Ltd

Hydrolysate of ovalbumin: production and evaluation of the functional properties of peptides

Chicken eggs proteins and their derivatives, like protein hydrolysates, peptides and amino acids, possess high nutritional value and provide a wide range of biological activity. They serve as sources for development of functional ingredients that draw the attention of specialists in the food production and biomedical industries, as well as the livestock feed industry. Enzymatic hydrolysis of proteins is a popular process for obtaining bioactive peptides with multifunctional properties. The purpose of this study is to obtain a hydrolysate of ovalbumin with a high degree of hydrolysis and to determine its functional and technological parameters. The research presents a two-stage scheme of ovalbumin hydrolysis with the help of pepsin and trypsin which provide high degree of hydrolysis (82–83%). The fractional composition of the hydrolysate is determined. The fractional composition is represented by three main fractions (high, medium and low molecular weight). The summarized antioxidant activity (SAA) of the hydrolysate is considered within the dynamics of the hydrolysis process. The highest SAA value was noted after 2 hours, and it amounted to 170.23 mg/l; at the end of hydrolysis the SAA value was equal to 114.31 mg/l. When analyzing the SAA, it was found that the main contribution to the summarized antioxidant activity of the ovalbumin hydrolysate is made by peptides of the medium molecular fraction. The microfiltration process, used in the research, made it possible to separate high-molecular compounds, which led to an increase in the SAA of the hydrolysate to 189.9 mg/l. The main functional and technological parameters of the hydrolysate are determined in this research. The comprehensive study of the biological activity and functional characteristics of egg protein hydrolysates and their peptides provides a theoretical basis for expanding the range of functional ingredients obtained from food proteins and for replenishing the range of functional foods.Chicken eggs proteins and their derivatives, like protein hydrolysates, peptides and amino acids, possess high nutritional value and provide a wide range of biological activity. They serve as sources for development of functional ingredients that draw the attention of specialists in the food production and biomedical industries, as well as the livestock feed industry. Enzymatic hydrolysis of proteins is a popular process for obtaining bioactive peptides with multifunctional properties. The purpose of this study is to obtain a hydrolysate of ovalbumin with a high degree of hydrolysis and to determine its functional and technological parameters. The research presents a two-stage scheme of ovalbumin hydrolysis with the help of pepsin and trypsin which provide high degree of hydrolysis (82–83%). The fractional composition of the hydrolysate is determined. The fractional composition is represented by three main fractions (high, medium and low molecular weight). The summarized antioxidant activity (SAA) of the hydrolysate is considered within the dynamics of the hydrolysis process. The highest SAA value was noted after 2 hours, and it amounted to 170.23 mg/l; at the end of hydrolysis the SAA value was equal to 114.31 mg/l. When analyzing the SAA, it was found that the main contribution to the summarized antioxidant activity of the ovalbumin hydrolysate is made by peptides of the medium molecular fraction. The microfiltration process, used in the research, made it possible to separate high-molecular compounds, which led to an increase in the SAA of the hydrolysate to 189.9 mg/l. The main functional and technological parameters of the hydrolysate are determined in this research. The comprehensive study of the biological activity and functional characteristics of egg protein hydrolysates and their peptides provides a theoretical basis for expanding the range of functional ingredients obtained from food proteins and for replenishing the range of functional foods

A method development for improving the stability of vegetable polyphenol complexes for semi-finished minced meat products with antioxidant effect

Polyphenolic vegetable complexes are active antioxidants and play an important role in the processes of free radicals quenching in the human body. The aim of the work was to develop an immobilization method as a way for improving the stability of polyphenols in dried cowberry squeezing extract (DCSE) and to develop semi-finished minced meat products with antioxidant effect without changing their nutritional value. Experiments were carried out to study the nutritional value of DCSE. The presence of a large number of polyphenolic compounds in DCSE and a high radical-binding ability of the extract were revealed. Based on the mathematical planning method, an offal paste composition was obtained, which was used to obtain pellets, and the formulation of semi-finished minced meat products with pellets was optimized. It was established that preliminary immobilization of DCSE on offal pellets components allows to increase the level of total antioxidant content in the minced meat. Subsequent heat treatment of semi-finished minced meat products produced from such minced meat showed an increase in stability and, thus, bioavailability of antioxidants and the possibility of obtaining a finished product with antioxidant effect. The antioxidant effect of cowberry squeezing extract in the meat system is proved: accumulation of lipid oxidative decomposition products in the meat system during storage of frozen semi-finished minced meat products was inhibited to a greater extent when using offal pellets with immobilized compounds of cowberry squeezing extract. This work was carried out as part of the State Assignment of the Ministry of Education and Science of the Russian Federation No. 19.5486.2017/BCh and the «Young Scientists of ESSTU‑2019» grant

Identifying the relationship between game addiction and emotional intelligence

This article presents the results of a study of the relationship between the level of severity of gaming disorder and emotional intelligence in students of different courses in different areas of study. The indicators of emotional intelligence and passion for computer games are compared.В данной статье представлены результаты исследования взаимосвязи уровня выраженности гейм-аддикции и эмоционального интеллекта у студентов разных курсов разных направлений обучения. Сравниваются показатели эмоционального интеллекта и увлеченности компьютерными играм

Effect of blueberry (vaccínium myrtíllus) leaves extract, obtained by microwave heating on the dynamics of animal fat oxidation processes

The potential of antioxidant properties of blueberry leaves extract (vaccínium myrtíllus) that grows in the Trans-Baikal region has been studied in this work. In order to increase the efficiency of extraction of biologically active substances with antioxidant properties, this extract was obtained with the help of microwave field. The optimal parameters for the extraction of active substances from the blueberry leaves with the help of electromagnetic microwave field have been defined. The influence of the power of the electromagnetic field and the duration of the process of blueberry leaves extraction on the efficiency of extraction of biologically active polyphenolic substances has been studied. The following parameters of the technology for blueberry leaves extraction were obtained: extraction with a water-alcohol solution with a concentration of 40% in the ratio of raw materials to extractant as 1 to 5, with duration of stirring as long as 30 minutes, then the application of an electromagnetic field of microwave heating with a power of 850W for 8–10 minutes long. Blueberry leaves extract is a clear liquid with a high content of polyphenols, of rich brown color, tart taste, without bitterness. The antioxidant potential of the obtained extract has been studied. To do this, the extract has been added into the finely ground animal fat and left for storage in a closed dark container. During storage, the dynamics of the peroxide number has been measured, as this value characterizes the degree of lipid oxidation. It has been found that blueberry leaves extract inhibits the process of animal fat oxidation due to the action of biologically active substances that feature antioxidant properties

Lence in parent-child relationships: a case study of preschool age

This article presents the results of research on the presence and manifestation of the signs of psychological abuse by parents on preschool children. The attitude of parents to their children is investigated using the method of diagnosing parental relationships by A. Varga, V.V. Stolin. As a result of the interpretation of the information obtained, general tendencies in child-parental relations, characteristic of this age, were revealedВ данной статье представлены результаты исследования наличия и проявление признаков психологического насилия со стороны родителей на детей дошкольного возраста. Исследуются отношение родителей к своим детям с помощью методики диагностики родительских отношений А.Я. Варга, В.В. Столин. В результате интерпретации полученных сведений, были выявлены общие тенденции в детско-родительских отношениях характерные данному возраст

Effect of lethal yellow (AY) mutation and photoperiod alterations on mouse behavior

Decrease in natural illumination in fall/winter months causes depressive-like seasonal affective disorders in vulnerable individuals. Obesity is another risk factor of depression. The lethal yellow (AY) mutation causes ectopic expression of agouti protein in the brain. Mice heterozygous for AY mutation (AY/a) are obese compared to their wild-type littermates (a/a). The main aims of the study were to investigate the effects of AY mutation, photoperiod and the interaction between these factors on daily activity dynamics, feeding, locomotor and exploratory activities, anxiety-related and depressive-like behaviors in mild stress condition. Six weeks old mouse males of AY/a and a/a lines were divided into four groups eight animals each and exposed to long- (14 h light and 10 h darkness) or short- (4 h light and 20 h darkness) day conditions for 28 days. Then the behavior of these mice was successively investigated in the home cage, open field, elevated plus-maze and forced swim tests. We did not observed any effect of AY mutation on the general activity, water and food consumption in the home cage; locomotion and exploration in the open field test; anxiety-related behavior in the open field and elevated plus-maze tests. At the same time, AY mutation increased depressive-like immobility time in the forced swim test (F1.28 = 20.03, p = 0.00012). Shortday conditions decreased nocturnal activity in the home cage, as well as locomotion (F1.28 = 16.33, p = 0.0004) and exploration (F1.28 = 16.24, p < 0.0004) in the open field test. Moreover, short-day exposition decreased time spent in the center of the open field (F1.28 = 6.57, p = 0.016) and in the open arms of the elevated plus-maze (F1.28 = 12.08, p = 0.0017) tests and increased immobility time in the forced swim test (F1.28 = 9.95, p = 0.0038). However, no effect of the interaction between AY mutation and photoperiod on immobility time in the forced swim test was observed. Therefore, short-day photoperiod and AY mutation increased depressive-like behavior in the forced swim test by means of different mechanisms

On the Relationships between Decision Management and Performance Measurement

Decision management is of utmost importance for the achievement of strategic and operational goals in any organisational context. Therefore, decisions should be considered as first-class citizens that need to be modelled, analysed, monitored to track their performance, and redesigned if necessary. Up to now, existing literature that studies decisions in the context of business processes has focused on the analysis of the definition of decisions themselves, in terms of accuracy, certainty, consistency, covering and correctness. However, to the best of our knowledge, no prior work exists that analyses the relationship between decisions and performance measurement. This paper identifies and analyses this relationship from three different perspectives, namely: the impact of decisions on process performance, the performance measurement of decisions, and the use of performance indicators in the definition of decisions. Furthermore, we also introduce solutions for the representation of these relationships based, amongst others, on the DMN standard.Ministerio de Economía y Competitividad BELI (TIN2015-70560-R)Junta de Andalucía P12-TIC-1867Junta de Andalucía P10-TIC-590

Efficacy and safety of rociletinib versus chemotherapy in patients with EGFR-mutated NSCLC: the results of TIGER-3, a phase 3 randomized study

Introduction: The TIGER-3 (NCT02322281) study was initiated to compare the efficacy and safety of rociletinib, a third-generation EGFR tyrosine kinase inhibitor (TKI) that targets EGFR T790M and common EGFR-activating mutations, versus chemotherapy in patients with NSCLC who progressed on first- or second-generation EGFR TKIs. Methods: Patients with advanced or metastatic EGFR-mutated NSCLC with disease progression on standard therapy (previous EGFR TKI and platinum-based chemotherapy) were randomized to oral rociletinib (500 or 625 mg twice daily) or single-agent chemotherapy (pemetrexed, gemcitabine, docetaxel, or paclitaxel). Results: Enrollment was halted when rociletinib development was discontinued in 2016. Of 149 enrolled patients, 75 were randomized to rociletinib (n = 53: 500 mg twice daily; n = 22: 625 mg twice daily) and 74 to chemotherapy. The median investigator-assessed progression-free survival (PFS) was 4.1 months (95% confidence interval [CI]: 2.6-5.4) in the rociletinib 500-mg group and 5.5 months (95% CI: 1.8-8.1) in the 625-mg group versus 2.5 months (95% CI: 1.4-2.9) in the chemotherapy group. An improved PFS was observed in patients with T790M-positive NSCLC treated with rociletinib (n = 25; 500 mg and 625 mg twice daily) versus chemotherapy (n = 20; 6.8 versus 2.7 mo; hazard ratio = 0.55, 95% CI: 0.28-1.07, p = 0.074). Grade 3 or higher hyperglycemia (24.0%), corrected QT prolongation (6.7%), diarrhea (2.7%), and vomiting (1.3%) were more frequent with rociletinib than chemotherapy (0%, 0%, 1.4%, and 0%, respectively). Conclusions: Rociletinib had a more favorable median PFS versus chemotherapy but had higher rates of hyperglycemia and corrected QT prolongation in patients with advanced EGFR-mutated NSCLC who progressed on previous EGFR TKI. Incomplete enrollment prevented evaluation of the primary efficacy end point

Психология дидактической коммуникации: инновации конструктивистского подхода

The article deals with the problems of constructivist reflection and the construction of didactic communication, the innovations, opportunities and limitations that the constructivist model of pedagogical interaction offers. The aim of the work was an analysis of innovations and perspectives of understanding the modern educational process in the context of the constructivist approach. Postmodern, the era of the late twentieth and early twenty-first centuries, leaving, leaves many interesting and productive developments, which undoubtedly include constructivism. Contesting the existence of reality as such, constructivism offered several solutions to the problem of man's comprehension of himself and the world. These solutions united by a common idea of producing internal and external reality in social dialogue, in the interaction of people and groups (actors and co-actors) interested in solving problems, united in situational, subject, active collaborations (associations, groups) to develop the best and satisfying all participants as stakeholders of a consensus solution of the problem. Constructivism has changed the view of what is happening in the relations of people in a number of areas, including management and education. Findings. Due to its debatable nature, the development of constructivism ideas in the context of the development of educational ideologies and technologies activates the processes of reconceptualization of the traditional model of didactic communication, and the constructionist model of education itself can and should become an object of systematic methodological, theoretical, empirical and applied research. Any of these approaches can be disclosed as an example of a constructivist educational model. The leading signs of this model are the dialogue nature of education, the focus on understanding the internal and external world in a dialogue with significant other people. This model assumes the consideration of such a dialogue as a process by which a person builds his own life world and himself, as a creative «rediscovery» of the basic truths of human existence, as making socially and personally meaningful decisions in a situation of educational, professional and life choices.В статье рассматриваются проблемы конструктивистского осмысления и конструирования дидактической коммуникации, т. е. инновации, возможности и ограничения, которые предлагает конструктивистская модель педагогического взаимодействия. Целью работы выступил анализ инноваций и перспектив осмысления современного образовательного процесса в контексте конструктивистского подхода. Постмодерн, эпоха конца ХХ и начала XXI в., уходя, оставляет множество интересных и продуктивных разработок, к числу которых относится, несомненно, и конструктивизм (constructivism). Оспаривая существование реальности как таковой, конструктивизм предложил несколько вариантов решения проблемы постижения человеком себя и мира, объединенных общей идеей производства внутренней и внешней реальности в социальном диалоге, во взаимодействии заинтересованных в решении проблем людей и групп (акторов и ко-акторов), объединенных в ситуативные, предметные, деятельные коллаборации (ассоциации, группы) для выработки оптимального и удовлетворяющего всех участников как стейкхолдеров консенсусного решения проблемы. Конструктивизм изменил взгляд на происходящее в отношениях людей в целом ряде сфер, включая менеджмент и образование. Выводы. Благодаря своей дискуссионности, развитие идей конструктивизма в контексте разработки образовательных идеологий и технологий активизирует процессы реконцептуализации традиционной модели дидактической коммуникации, а сама конструкционистская модель образования может и должна стать объектом систематических методологических, теоретических, эмпирических и прикладных исследований. Любой из перечисленных подходов может быть раскрыт как пример конструктивисткой модели образования, ведущими признаками которой являются диалогичность образования, нацеленность на осмысление внутреннего и внешнего мира в диалоге со значимыми другими людьми, рассмотрение такого диалога как процесса построения человеком собственного жизненного мира и самого себя, как творческого «переоткрытия» базовых истин человеческого существования, как принятие социально и личностно значимых решений в ситуации учебного, профессионального, жизненного выбора