Internal parasites and association with diarrhoea in sheep at an abattoir in Western Australia

Diarrhoea (scouring) is an important issue for the sheep meat industry. Scouring is a major risk factor for fleece soiling and consequential carcase contamination with microbes that cause meat spoilage and potential dangers for humans (2). There is little information on the causes of scouring in sheep at slaughter. Strongyle worm infections are commonly implicated in scouring and reduced production, yet there is no published data quantifying strongyle infections in scouring and normal sheep at abattoirs. In addition, Giardia and Cryptosporidium have been associated with scouring in ruminants, but little is known about the prevalence, genotypes present or the effect on production in sheep populations. This study carried out at an abattoir in Western Australia (WA), aimed to investigate the extent of strongyle, Giardia and Cryptosporidium infections and any association with scouring in sheep

Increasing digesta viscosity may increase parasite establishment in the small intestine of sheep

Strongyle infections and diarrhoea are major problems for the sheep industry, but the nutritional factors determining faecal consistency and susceptibility to enteric diseases are not well understood. Soluble non-starch polysaccharides (sNSP) have been shown to affect the physico-chemical environment of the gut lumen, by increasing viscosity of digesta and affecting microbial fermentation in the large intestine; however, the role of sNSP in sheep has not been studied. sNSP have been shown to increase parasite establishment in the small intestine of mice (3) and decrease parasite establishment in the large intestine of pigs (2). Carboxymethylcellulose (CMC) is a non-fermentable viscous-forming agent that is used to study the effect of soluble NSP in increasing digesta viscosity independent of potential effects on fermentation (I). The aims of this study were to investigate whether increasing viscosity of digesta using CMC may affect establishment of Trichostrongylus colubriformis and Telodorsagio (Ostenagia) circumcincta in sheep and whether the type of roughage and CMC may affect faecal consistency in sheep with strongyle infections

Changes in worm control practices on Western Australian sheep farm 1981-2002

Surveys to assess the use of agricultural practices provide "point-in-time" snapshots of what farmers do on their farms. The results can then be compared across regions or over time. Often, comparisons over time allow an assessment to be made about the efficacy of extension campaigns to change such practices. Gastro-intestinal nematodiasis is a serious production-limiting disease affecting Australian sheep and is further complicated by the widespread occurrence of anthelmintic resistance (1). Awareness of anthelmintic resistance has driven extension efforts to modify the worm control practices employed by farmers. Surveys in the 1980's in Western Australia, estimated worm control practices and showed high levels of benzimidazole and levamisole resistance (3, 4). These findings initiated the "CRACK" campaign, which aimed to limit anthelmintic resistance. With the rising prevalence of ivermectin resistance detected in the 1990's, an extension campaign to modify summer drenching practices was commenced early in 2001-2002. This paper compares five surveys of worm control practices conducted between 1981 and 2002 and discusses the changes against the extension campaigns waged

Increasing viscosity of digesta has detrimental effects on faecal consistency in sheep

Although diarrhoea and faecal soiling of fleece are major problems for the sheep meat and wool industries, there is little information on the nutritional factors that determine faecal consistency in sheep. Research in monogastric species has shown that the soluble non-starch polysaccharide (sNSP) content of the diet is a major determinant of faecal consistency and susceptibility of animals to enteric diseases (2, 3), but there have been no studies on the role of sNSP in sheep. sNSP have profound effects on the physio-chemical conditions of the gut lumen by increasing viscosity of digesta and affecting microbial fermentation in the large intestine (2). Carboxymethylcellulose (CMC) is a non-fermentable viscous-forming agent that has been used in pig diets to study the effect of sNSP of increasing digesta viscosity, independently of potential effects on fermentation (2). This study aimed to investigate if CMC could be used as a model for studying the effect of increasing digesta viscosity in sheep and whether dietary CMC supplementation would have any detrimental effects on faecal consistency

Safety of hospital discharge before return of bowel function after elective colorectal surgery

Background: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods: A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien\u2013Dindo classification system. Results: A total of 3288 patients were included in the analysis, of whom 301 (9\ub72 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4\u20137) and 7 (6\u20138) days respectively (P < 0\ub7001). There were no significant differences in rates of readmission between these groups (6\ub76 versus 8\ub70 per cent; P = 0\ub7499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0\ub790, 95 per cent c.i. 0\ub755 to 1\ub746; P = 0\ub7659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34\ub77 versus 39\ub75 per cent; major 3\ub73 versus 3\ub74 per cent; P = 0\ub7110). Conclusion: Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients

Safety of hospital discharge before return of bowel function after elective colorectal surgery

© 2020 BJS Society Ltd Published by John Wiley & Sons LtdBackground: Ileus is common after colorectal surgery and is associated with an increased risk of postoperative complications. Identifying features of normal bowel recovery and the appropriateness for hospital discharge is challenging. This study explored the safety of hospital discharge before the return of bowel function. Methods: A prospective, multicentre cohort study was undertaken across an international collaborative network. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The main outcome of interest was readmission to hospital within 30 days of surgery. The impact of discharge timing according to the return of bowel function was explored using multivariable regression analysis. Other outcomes were postoperative complications within 30 days of surgery, measured using the Clavien–Dindo classification system. Results: A total of 3288 patients were included in the analysis, of whom 301 (9·2 per cent) were discharged before the return of bowel function. The median duration of hospital stay for patients discharged before and after return of bowel function was 5 (i.q.r. 4–7) and 7 (6–8) days respectively (P < 0·001). There were no significant differences in rates of readmission between these groups (6·6 versus 8·0 per cent; P = 0·499), and this remained the case after multivariable adjustment for baseline differences (odds ratio 0·90, 95 per cent c.i. 0·55 to 1·46; P = 0·659). Rates of postoperative complications were also similar in those discharged before versus after return of bowel function (minor: 34·7 versus 39·5 per cent; major 3·3 versus 3·4 per cent; P = 0·110). Conclusion: Discharge before return of bowel function after elective colorectal surgery appears to be safe in appropriately selected patients

Safety and efficacy of non-steroidal anti-inflammatory drugs to reduce ileus after colorectal surgery

Background: Ileus is common after elective colorectal surgery, and is associated with increased adverse events and prolonged hospital stay. The aim was to assess the role of non-steroidal anti-inflammatory drugs (NSAIDs) for reducing ileus after surgery. Methods: A prospective multicentre cohort study was delivered by an international, student- and trainee-led collaborative group. Adult patients undergoing elective colorectal resection between January and April 2018 were included. The primary outcome was time to gastrointestinal recovery, measured using a composite measure of bowel function and tolerance to oral intake. The impact of NSAIDs was explored using Cox regression analyses, including the results of a centre-specific survey of compliance to enhanced recovery principles. Secondary safety outcomes included anastomotic leak rate and acute kidney injury. Results: A total of 4164 patients were included, with a median age of 68 (i.q.r. 57\u201375) years (54\ub79 per cent men). Some 1153 (27\ub77 per cent) received NSAIDs on postoperative days 1\u20133, of whom 1061 (92\ub70 per cent) received non-selective cyclo-oxygenase inhibitors. After adjustment for baseline differences, the mean time to gastrointestinal recovery did not differ significantly between patients who received NSAIDs and those who did not (4\ub76 versus 4\ub78 days; hazard ratio 1\ub704, 95 per cent c.i. 0\ub796 to 1\ub712; P = 0\ub7360). There were no significant differences in anastomotic leak rate (5\ub74 versus 4\ub76 per cent; P = 0\ub7349) or acute kidney injury (14\ub73 versus 13\ub78 per cent; P = 0\ub7666) between the groups. Significantly fewer patients receiving NSAIDs required strong opioid analgesia (35\ub73 versus 56\ub77 per cent; P &lt; 0\ub7001). Conclusion: NSAIDs did not reduce the time for gastrointestinal recovery after colorectal surgery, but they were safe and associated with reduced postoperative opioid requirement