A Variational Approach to Perturbed Discrete Anisotropic Equations

We continue the study of discrete anisotropic equations and we will provide new multiplicity results of the solutions for a discrete anisotropic equation. We investigate the existence of infinitely many solutions for a perturbed discrete anisotropic boundary value problem. The approach is based on variational methods and critical point theory

Angiotensin-Converting Enzyme Inhibitor Therapy Affects Left Ventricular Mass in Patients With Ejection Fraction >40% After Acute Myocardial Infarction

AbstractObjectives. We tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitor therapy decreases left ventricular (LV) mass in patients with a left ventricular ejection fraction (LVEF) >40% and no evidence of heart failure after their first acute Q wave myocardial infarction (MI).Background. Recently, ACE inhibitor therapy has been shown to have an early mortality benefit in unselected patients with acute MI, including patients without heart failure and a LVEF >35%. However, the effects on LV mass and volume in this patient population have not been studied.Methods. Thirty-five patients with a LVEF >40% after their first acute Q wave MI were randomized to titrated oral ramipril (n = 20) or conventional therapy (control, n = 15). Magnetic resonance imaging (MRI) performed an average of 7 days and 3 months after MI provided LV volumes and mass from summated serial short-axis slices.Results. Left ventricular end-diastolic volume index did not change in ramipril-treated patients (62 ± 16 [SD] to 66 ± 17 ml/m2) or in control patients (62 ± 16 to 68 ± 17 ml/m2), and stroke volume index increased significantly in both groups. However, LV mass index decreased in ramipril-treated patients (82 ± 18 to 73 ± 19 g/m2, p = 0.0002) but not in the control patients (77 ± 15 to 79 ± 23 g/m2). Systolic arterial pressure did not change in either group at 3-month follow-up.Conclusions. In patients with a LVEF >40% after acute MI, ramipril decreased LV mass, and blood pressure and LV function were unchanged after 3 months of therapy. Whether the decrease in mass represents a sustained effect that is associated with a decrease in morbid events requires further investigation.(J Am Coll Cardiol 1997;29:49–54)

Perturbed nonlocal fourth order equations of Kirchhoff type with Navier boundary conditions

Abstract We investigate the existence of multiple solutions for perturbed nonlocal fourth-order equations of Kirchhoff type under Navier boundary conditions. We give some new criteria for guaranteeing that the perturbed fourth-order equations of Kirchhoff type have at least three weak solutions by using a variational method and some critical point theorems due to Ricceri. We extend and improve some recent results. Finally, by presenting two examples, we ensure the applicability of our results

The structure of the tetrasialoganglioside from human brain

Autosomal dominant retinal vasculopathy with cerebral leukodystrophy is a microvascular endotheliopathy with middle- age onset. In nine families, we identified heterozygous C- terminal frameshift mutations in TREX1, which encodes a 3'-5' exonuclease. These truncated proteins retain exonuclease activity but lose normal perinuclear localization. These data have implications for the maintenance of vascular integrity in the degenerative cerebral microangiopathies leading to stroke and dementias

Generalized Yamabe equations on Riemannian manifolds and applications to Emden-Fowler problems

In this paper, we establish the existence of solutions and multiplicity properties for generalized Yamabe equations on Riemannian manifolds.  Problems of this type arise in conformal Riemannian geometry, astrophysics, and in the theories of thermionic emission, isothermal stationary gas sphere, and gas combustion. The abstract results of this paper are illustrated with Emden-Fowler equations involving sublinear terms at innity. Two examples reveal the analytic setting of this paper. Key words: Three solutions, generalized Yamabe equations, Riemannian manifold, Emden-Fowler problem, variational methods

Existence Results for Dynamic Sturm-Liouville Boundary Value Problems Via Variational Methods

Several conditions ensuring existence of solutions of a dynamic Sturm-Liouville boundary value problem are derived. Variational methods are utilized in the proofs. An example illustrating the main results is given

Fuzzy-logic Method for Global Quality Optimization Problem of the Programmed Action Investment

 In order to analyze the planning of a transport linear infrastructure (railway or ordinary road), in order to optimize a relationship work-environment after-work, the study team (engineers,architects, economists, etc), realize a careful prearranged analysis about the characteristic of the site and the large area which are involved by the work project and, once one found all possible alternative solutions, he should compare them through the use of suitable technical, economical and environmental parameters, choosing that one which maximize the global utility of the public investment. In this paper we study a fuzzy-logic method in order to help the decision maker in the analysis of the programmed action public investment

Measurement of Left Ventricular Ejection Fraction Using Gated 99mTc-Sestamibi Myocardial Planar Images: Comparison to Contrast Ventriculography

Using the new myocardial perfusion agent 99mTc-sestamibi and multigated acquisition on a nuclear medicine gamma camera, the left ventricular ejection fraction (LVEF) was derived in 13 patients with coronary artery disease (CAD). Cross-sectional activity profiles were used to measure the left ventricle from end-diastolic and end-.systolic images. Several different geometric methods were then utilized to derive ejection fractions from the nuclear data. Comparison of the resultant ejection fractions to those obtained from contrast ventriculography showed significant correlation for all geometric methods (P \u3c 0.01,S y X x = 6.2 to 9.6). We conclude that in patients with CAD one or more of these simple geometric methods can provide a useful estimate of the LVEF when performing 99mTc-sestamibi multigated myocardial perfusion imaging