An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans

none24noneS. BONASSI; A. ZNAOR; M. CEPPI; C. LANDO; W.P. CHANG; N. HOLLAND; M. KIRSCH-VOLDERS; E. ZEIGER; S. BAN; R. BARALE; M.P. BIGATTI; C. BOLOGNESI; A. CEBULSKA-WASILEWSKA; E. FABIANOVA; A. FUCIC; L. HAGMAR; G. JOKSIC; A. MARTELLI; L. MIGLIORE; E. MIRKOVA; M.R. SCARFI; A. ZIJNO; H. NORPPA; M. FENECHS., Bonassi; A., Znaor; M., Ceppi; C., Lando; W. P., Chang; N., Holland; M., KIRSCH VOLDERS; E., Zeiger; S., Ban; R., Barale; M. P., Bigatti; C., Bolognesi; A., CEBULSKA WASILEWSKA; E., Fabianova; A., Fucic; L., Hagmar; G., Joksic; Martelli, ANTONIETTA MARIA; L., Migliore; E., Mirkova; M. R., Scarfi; A., Zijno; H., Norppa; M., Fenec

NIRS International Symposium on Visualization of Radiation Response at the Molecular and Cellular Levels

細胞・分子イメージング研究の近年の発展を背景にして、国際・交流課と重粒子医科学センター粒子線生物研究グループとの共催で、３月12-13日に「細胞および分子レベルでの放射線応答の可視化」(Visualization of Radiation Response at the Molecular and Cellular Levels)と題する放医研国際シンポジウムを開催した

バイヨウサレタヒトニバイタイサイボウニオヨボスデンリホウシャセンタンイツショウシャノキュウセイコウカトバンハツコウカ

京都大学0048新制・課程博士医学博士甲第2311号医博第542号新制||医||269(附属図書館)6099UT51-55-G6京都大学大学院医学研究科生理系専攻(主査)教授 阿部 光幸, 教授 鳥塚 莞爾, 教授 菅原 努学位規則第5条第1項該当Kyoto UniversityDA

HETEROGENEOUS RADIATION SENSITIVITY OR DEDIFFERENTIATION OF ESOPHAGEAL CANCER CELLS MAY CAUSE THE POOR RADIOTHERAPEUTIC RESULTS ON ESOPHAGEAL CANCER

Because 90% of esophageal cancer is diagnosed at a late stage, it is frequently treated using radiotherapy. However, overall therapeutic results are poor, and no one knows why. In this paper, two hypotheses to explain these poor therapeutic results will be discussed. A radiation sensitivity test on 31 human esophageal squamous cell carcinoma cell lines with a colony-formation assay demonstrated a large variation in radiosensitivity among cell lines. We can hypothesize that the existence of radioresistant cancer cell lines may partly explain the poor results or radiotherapy for this cancer

Dose Thioredoxin-1 Prevent Mitochondria- and Endoplasmic Reticulum-Mediated Neurotoxicity of 1-Methyl-4-phenyl-1,2,3,6-Tetrahydropyridine?

We show that 1-methyl-4-phenylpyridinium ion(MPP+), and active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP),induces cytotoxicity via endoplasmic reticulum(ER)-and mitochondria-mediated pathways, and thioredoxin-1(TRX-1), a redox-active protein, prevents MPTP-induced neurotoxicity

Radiation sensitivity determined by the flow of information through intracellular networks

Gordon Research Conference