8 research outputs found
String theory duals of Lifshitz-Chern-Simons gauge theories
We propose candidate gravity duals for a class of non-Abelian z=2 Lifshitz
Chern-Simons (LCS) gauge theories studied by Mulligan, Kachru and Nayak. These
are nonrelativistic gauge theories in 2+1 dimensions in which parity and
time-reversal symmetries are explicitly broken by the presence of a
Chern-Simons term. We show that these field theories can be realized as
deformations of DLCQ N=4 super Yang-Mills theory. Using the holographic
dictionary, we identify the bulk fields that are dual to these deformations.
The geometries describing the groundstates of the non-Abelian LCS gauge
theories realized here exhibit a mass gap.Comment: 25+14 pages, 3 figures; v2: significant corrections regarding IR
geometry, resulting in new section 5; journal versio
Lifshitz spacetimes from AdS null and cosmological solutions
We describe solutions of 10-dimensional supergravity comprising null
deformations of with a scalar field, which have
Lifshitz symmetries. The bulk Lifshitz geometry in 3+1-dimensions arises by
dimensional reduction of these solutions. The dual field theory in this case is
a deformation of the N=4 super Yang-Mills theory. We discuss the holographic
2-point function of operators dual to bulk scalars. We further describe
time-dependent (cosmological) solutions which have anisotropic Lifshitz scaling
symmetries. We also discuss deformations of in 11-dimensional
supergravity, which are somewhat similar to the solutions above. In some cases
here, we expect the field theory duals to be deformations of the Chern-Simons
theories on M2-branes stacked at singularities.Comment: Latex, 29pgs, v3. references, minor clarifications (subsection on
Lifshitz geometry seen by scalar probes) added, to appear in JHE
The particle number in Galilean holography
Recently, gravity duals for certain Galilean-invariant conformal field
theories have been constructed. In this paper, we point out that the spectrum
of the particle number operator in the examples found so far is not a necessary
consequence of the existence of a gravity dual. We record some progress towards
more realistic spectra. In particular, we construct bulk systems with
asymptotic Schrodinger symmetry and only one extra dimension. In examples, we
find solutions which describe these Schrodinger-symmetric systems at finite
density. A lift to M-theory is used to resolve a curvature singularity. As a
happy byproduct of this analysis, we realize a state which could be called a
holographic Mott insulator.Comment: 29 pages, 1 rudimentary figure; v2: typo in eqn (3.4), added comments
and ref
Nickel catalyzed synthesis of 4,4âČ-bichromenes/4,4âČ-bithiochromenes and their Atropisomerism
4,4âČ-bichromenes and 4,4âČ-bithiochromenes have been synthesized by a Ni catalyzed homocoupling method and their Atropisomeric behavior has been studied
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Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate
The widespread emergence of Plasmodium falciparum (Pf) strains resistant to frontline agents has fuelled the search for fast-acting agents with novel mechanism of action. Here, we report the discovery and optimization of novel antimalarial compounds, the triaminopyrimidines (TAPs), which emerged from a phenotypic screen against the blood stages of Pf. The clinical candidate (compound 12) is efficacious in a mouse model of Pf malaria with an ED99 <30 mg kgâ1 and displays good in vivo safety margins in guinea pigs and rats. With a predicted half-life of 36 h in humans, a single dose of 260 mg might be sufficient to maintain therapeutic blood concentration for 4â5 days. Whole-genome sequencing of resistant mutants implicates the vacuolar ATP synthase as a genetic determinant of resistance to TAPs. Our studies highlight the potential of TAPs for single-dose treatment of Pf malaria in combination with other agents in clinical development
Aminoazabenzimidazoles, a Novel Class of Orally Active Antimalarial Agents
Whole-cell high-throughput
screening of the AstraZeneca compound
library against the asexual blood stage of Plasmodium
falciparum (<i>Pf</i>) led to the identification
of amino imidazoles, a robust starting point for initiating a hit-to-lead
medicinal chemistry effort. Structureâactivity relationship
studies followed by pharmacokinetics optimization resulted in the
identification of <b>23</b> as an attractive lead with good
oral bioavailability. Compound <b>23</b> was found to be efficacious
(ED<sub>90</sub> of 28.6 mg·kg<sup>â1</sup>) in the humanized P. falciparum mouse model of malaria (<i>Pf</i>/SCID model). Representative compounds displayed a moderate to fast
killing profile that is comparable to that of chloroquine. This series
demonstrates no cross-resistance against a panel of <i>Pf</i> strains with mutations to known antimalarial drugs, thereby suggesting
a novel mechanism of action for this chemical class