A study of dental disease in the horse

Summary avaiilable; p. iii-iv

TECHNOLOGIES THAT TRANSFORM BUSINESS AND RESEARCH: LESSONS FROM THE PAST AS WE LOOK TO THE FUTURE

What are the technologies that will transform business and drive the research agenda for the IS field in the years to come? Which innovations, platforms, and paradigms will become dominant, and which others will ultimately pass into obscurity? In this panel discussion, we will seek answers to these questions from those with a unique and unmatched perspective. The leaders who have witnessed the birth and development of the IS field during the past 40- 50 years will draw on their experiences and their deep knowledge of the field to identify the characteristics of technologies that have changed business in the past. They will also explain how and why today’s innovations will change both research and practice going forward. Their insights have the potential to identify topics for researchers to examine now and in the years to come

Pacing accuracy during an incremental step test in adolescent swimmers

To assess pacing accuracy in a group of adolescent swimmers during an incremental step test. Fifteen well-trained swimmers (age 15±1.5 years; height 170.2±8.8 cm; mass 60.2±6.6 kg), completed two 7×200 m tests, separated by ~72 hours. They swam to a predetermined incrementally increasing pace per step and were instructed to swim at even pace. Upon completion of each step, rating of perceived exertion, heart rate and blood lactate were recorded. Significant differences observed for both trials between actual and predicted swim time (P<0.05). Significant differences also observed between the first and second 100 m of each step in trial 1 for step 1 (P=0.001, effect size [ES] =0.54), step 2 (P=0.0001, ES =0.57), step 4 (P=0.0001, ES =0.53), step 5 (P=0.005, ES =0.65), step 6 (P=0.0001, ES =0.50), and step 7 (P=0.0001, ES =0.70). Similar responses witnessed for trial 2 (P<0.05). Findings suggest that the finite anaerobic capacity was engaged sooner than would normally be anticipated, as a function of an inability to regulate pace. This is proposed to be a consequence of the volume of exposure to the biological and psychological sensations and cognitive developmental status. Given the apparent error in pacing judgment exhibited in this population group, caution should be applied when adopting such tests to monitor training responses with adolescent athletes, and alternate means of modulating pace be investigated

Prior Knowledge of Trial Number Influences the Incidence of Plateau at VO2max

The purpose of this study was to assess the VO2max plateau response at VO2max during a series of pre-determined trials. METHODS: Ten male well-trained athletes (age, 23.0 ± 3.2; height, 183.3 ± 5.5 cm; mass 77.5 ± 11.1 Kg; VO2max 66.5 ± 5.0 ml.kg-1,min-1), but who were VO2max testing naïve and with prior-knowledge of trial number completed four incremental tests to volitional exhaustion, separated by ~72-h for the determination of VO2max and gas exchange threshold. Throughout all trials VO2max was recorded on a breath-by-breath basis using a pre-calibrated metabolic cart, using a plateau criterion of Δ VO2 ≤1.5 ml.kg-1.min-1 over the final 2 consecutive 30 s sampling periods. A significant difference was observed between trial-1 and trial-4 for plateau incidence (p = 0.0285) rising from 20% in trial-1 to a 70% response rate in trial-4. Furthermore a significant difference was observed for VO2dif (difference be-tween criterion value and Δ VO2) in trial-1, 1.02 ± 1.69 ml.kg-1.min-1 (p = 0.038), with non-significant differences observed for all other trials, despite a non-significant difference for VO2max across all trials (p > 0.05). Finally, a significant difference was observed for effort perception (RPE) at volitional exhaustion between trial-1 (17.7 ± 1.3) and trial-4 (19.0 ± 1.4) (p = 0.0052). These data indicate that prior-knowledge of trial number can influence the manifestation of the VO2 plateau in a group of well-trained male athletes, thereby suggesting that a form of effort control is established in order to preserve the finite anaerobic capacity

Shining a light on clinical spectroscopy : translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic

In recent years, the application of vibrational spectroscopy in biomedical research has rapidly expanded; covering aspects of pharmaceutical development, to point-of-care technologies. Vibrational spectroscopy techniques such as Fourier-transform IR (FTIR), and Raman spectroscopy have been at the forefront of this movement, with their complementary information able to shine light onto a range of medical applications. As a relative newcomer to biomedical applications, two-dimensional (2D)-IR is also gaining traction in the field. Here we describe the recent development of these techniques as analytical tools in medical science, and their relative advancements towards the clinic

Program Corporate Social Responsibility Dalam Perspektif Indeks Kepuasan Publik Di Riau

Program Corporate Social Reponsibility (CSR) merupakan salah satu kebutuhan dan di Indonesia merupakan suatu kewajiban dan ditetapkan melalui Undang-Undang Nomor 40 Tahun 2007 tentang Perseroan Terbatas. Dimana pada pasal 74 menjelaskan bahwa tanggung jawab sosial merupakan suatu kegiatan yang diwajibkan dan dilaksanakan berdasarkan pada kepatutan dan kewajaran sesuai dengan peraturan pemerintahan. Pelaksanaan tanggung jawab sosial dikenal dengan istilah CSR oleh Perusahaan merupakan suatu bentuk komitmen Perusahaan untuk membangun kualitas kehidupan yang lebih baik bersama stakeholders terkait, terutama masyarakat disekitar Perusahaan tersebut berada. Karena peran CSR ternyata saat ini semakin penting bagi masyarakat di sekitar Perusahaan dalam upaya menyeimbangkan pembangunan, baik ekonomi, sosial dan lingkungan. Penelitian ini dilaksanakan secara komprehensif mengenai implementasi dan prioritas program CSR di PT. Pertamina (Persero) RU II Dumai dan PT. Cevron Pasific Indonesia (CPI) di Tapung, Minas dan Rumbai Provinsi Riau. Metode penelitian dilakukan dengan metode campuran (mixed methods) yaitu mengkombinasikan pendekatan kuantitatif dan pendekatan kualitatif. Pengumpulan data dilakukan dengan penyebaran angket, in-dept interview dan observasi terhadap multistakeholders. Hasil penelitian yang ditemukan implementasi program CSR oleh PT. Pertamina (Persero) RU II Dumai dan PT. Cevron Pasific Indonesia (CPI) di Provinsi Riau masih berjalan dengan kurang baik. Sedangkan prioritas program CSR yang dibutuhkan berdasarkan indeks kepuasan publik di PT. Pertamina (Persero) RU II Dumai dan PT. Cevron Pasific Indonesia (CPI) di Tapung, Minas dan Rumbai Provinsi Riau adalah program yang berbasis pemberdayaan ekonomi masyarakat.Kata Kunci: pemberdayaan, program Corporate Social Reponsibility, indeks kepuasan publik. Corporate Social Reponsibility program (CSR) is seen as an urgent thing on social development. Its supported by regulation that stated in Act No. 40 year 2007 about Limited Company. In the article number 74 stated that social responsibility is one among activities that should be conducted by the companies. The companies should have committed for surround people quality of life, in terms of social and economic perspective. The sample of this research covers the implementation of the priority programmes and corporate social responsibility (CSR) PT. Pertamina (Persero) RU II Dumai and PT. Cevron Pacific Indonesia (CPI) at Tapung, Minas and Rumbai Riau Province. Data has been collected by questionnaire, in-depth interview and observation. Results of the study found implementation of programs of corporate social responsibility by PT. Pertamina (Persero) RU II Dumai and PT Cevron Pacific Indonesia (CPI) in Riau Province is still inadequate. The CSR program of the sample have been emphasized on social-economy empowerment

Temporal fluctuation of multidrug resistant salmonella typhi haplotypes in the mekong river delta region of Vietnam.

BACKGROUND: typhoid fever remains a public health problem in Vietnam, with a significant burden in the Mekong River delta region. Typhoid fever is caused by the bacterial pathogen Salmonella enterica serovar Typhi (S. Typhi), which is frequently multidrug resistant with reduced susceptibility to fluoroquinolone-based drugs, the first choice for the treatment of typhoid fever. We used a GoldenGate (Illumina) assay to type 1,500 single nucleotide polymorphisms (SNPs) and analyse the genetic variation of S. Typhi isolated from 267 typhoid fever patients in the Mekong delta region participating in a randomized trial conducted between 2004 and 2005. PRINCIPAL FINDINGS: the population of S. Typhi circulating during the study was highly clonal, with 91% of isolates belonging to a single clonal complex of the S. Typhi H58 haplogroup. The patterns of disease were consistent with the presence of an endemic haplotype H58-C and a localised outbreak of S. Typhi haplotype H58-E2 in 2004. H58-E2-associated typhoid fever cases exhibited evidence of significant geo-spatial clustering along the Sông H u branch of the Mekong River. Multidrug resistance was common in the established clone H58-C but not in the outbreak clone H58-E2, however all H58 S. Typhi were nalidixic acid resistant and carried a Ser83Phe amino acid substitution in the gyrA gene. SIGNIFICANCE: the H58 haplogroup dominates S. Typhi populations in other endemic areas, but the population described here was more homogeneous than previously examined populations, and the dominant clonal complex (H58-C, -E1, -E2) observed in this study has not been detected outside Vietnam. IncHI1 plasmid-bearing S. Typhi H58-C was endemic during the study period whilst H58-E2, which rarely carried the plasmid, was only transient, suggesting a selective advantage for the plasmid. These data add insight into the outbreak dynamics and local molecular epidemiology of S. Typhi in southern Vietnam