Relationship between cardiovascular risk and lipid testing in one health care system: a retrospective cohort study.

BackgroundThe US Preventive Services Taskforce (USPSTF) recommends routine lipid screening beginning age 35 for men [1]. For women age 20 and older, as well as men age 20-34, screening is recommended if cardiovascular risk factors are present. Prior research has focused on underutilization but not overuse of lipid testing. The objective is to document over- and under-use of lipid testing in an insured population of persons at low, moderate and high cardiovascular disease (CVD) risk for persons not already on statins.MethodsThe study is a retrospective cohort study that included all adults without prior CVD who were continuously enrolled in a large integrated healthcare system from 2005 to 2010. Measures included lipid test frequency extracted from administrative data and Framingham cardiovascular risk equations applied using electronic medical record data. Five year lipid testing patterns were examined by age, sex and CVD risk. Generalized linear models were used to estimate the relative risk for over testing associated with patient characteristics.ResultsAmong males and females for whom testing is not recommended, 35.8 % and 61.5 % received at least one lipid test in the prior 5 years and 8.4 % and 24.4 % had two or more. Over-testing was associated with age, race, comorbidity, primary care use and neighborhood income. Among individuals at moderate and high-risk (not already treated with statins) and for whom screening is recommended, between 21.4 % and 25.1 % of individuals received no screening in the prior 5 years.ConclusionsBased on USPSTF lipid screening recommendations, this study documents substantial over-testing among individuals with low CVD risk and under-testing among individuals with moderate to high-risk not already on statins. Opportunity exists to better focus lipid screening efforts appropriate to CVD risk

Trigonometric Parallaxes of Massive Star Forming Regions: VIII. G12.89+0.49, G15.03-0.68 (M17) and G27.36-0.16

We report trigonometric parallaxes for three massive star forming regions, corresponding to distances of $2.34^{+0.13}_{-0.11}$ kpc for G12.89+0.49 (also known as IRAS 18089-1732),$1.98^{+0.14}_{-0.12}$ kpc for G15.03-0.68 (in the M17 region), and $8.0^{+4.0}_{-2.0}$ kpc for G27.36-0.16. Both G12.89+0.49 and G15.03-0.68 are located in the Carina-Sagittarius spiral arm

Isolation and characterisation of 17 microsatellite loci for the red-billed chough (Pyrrhocorax pyrrhocorax)

Peer reviewedPostprin

Non-parametric comparison of histogrammed two-dimensional data distributions using the Energy Test

When monitoring complex experiments, comparison is often made between regularly acquired histograms of data and reference histograms which represent the ideal state of the equipment. With the larger HEP experiments now ramping up, there is a need for automation of this task since the volume of comparisons could overwhelm human operators. However, the two-dimensional histogram comparison tools available in ROOT have been noted in the past to exhibit shortcomings. We discuss a newer comparison test for two-dimensional histograms, based on the Energy Test of Aslan and Zech, which provides more conclusive discrimination between histograms of data coming from different distributions than methods provided in a recent ROOT release.The Science and Technology Facilities Council, U

Position-momentum local realism violation of the Hardy type

We show that it is, in principle, possible to perform local realism violating experiments of the Hardy type in which only position and momentum measurements are made on two particles emanating from a common source. In the optical domain, homodyne detection of the in-phase and out-of-phase amplitude components of an electromagnetic field is analogous to position and momentum measurement. Hence, local realism violations of the Hardy type are possible in optical systems employing only homodyne detection.Comment: 10 pages, no figures, to be published in Physical Review

Trigonometric Parallaxes of Massive Star Forming Regions: IV. G35.20-0.74 and G35.20-1.74

We report trigonometric parallaxes for the high-mass star forming regions G35.20-0.74 and G35.20-1.74, corresponding to distances of 2.19 (+0.24 -0.20) kpc and 3.27 (+0.56 -0.42) kpc, respectively. The distances to both sources are close to their near kinematic distances and place them in the Carina-Sagittarius spiral arm. Combining the distances and proper motions with observed radial velocities gives the locations and full space motions of the star forming regions. Assuming a standard model of the Galaxy, G35.20-0.74 and G35.20-1.74 have peculiar motions of ~13 km/s and ~16 km/s counter to Galactic rotation and ~9 km/s toward the North Galactic Pole.Comment: 16 pages, 8 figure