Thrombelastografische untersuchungen bei patienten mit veranderungen des Koagulum

Koristeći trombelastografska ispitivanja, trebalo je dokazati, koji su opšti i lokalni činioci mogli uticati na propadanje koaguluma u rani posle vađenja zuba. Ova ispitivanja su vršena u 13 pacijenata, u kojih su komplikacije nastale u smislu produženog krvavljenja (pet) i alveolita (osam). Rezultati trombelastografskih merenja pokazuju, da su promene nastale u rani, posle vađenja zuba, posledica dejstva lokalnih činilaca (trauma, pljuvačka, infekcija), a ne promena u opštem sistemu koagulacije i fibrinolize (humoralnom sistemu). Trombelastogrami pokazuju, u devet slučajeva, hiperkoagulabilnu reakciju krvi, a u četiri slučaja, normokoagulabiinost. Moglo bi se, čak, pretpostaviti, da su u slučajevima hiperkoagulabilnosti i reakcije fibrinolize bile ubrzane.The thrombelastographic investigation was applied to find out which general and focal factors could influence the destruction of coagulum in the wound caused by a tooth extraction. The investigation was carried out in 13 patients, including five cases with prolongated bleeding and eight cases with alveolations. The results of the trombelastographic measurements show that the changes in the wound caused by a tooth extraction are due to the effect of local factors (trauma, saliva and infection) and not to the general system of coagulation and fibrinolysis (humoral system). Thrombelastograms show hypercoagulable blood reaction in nine cases and normal coagulability in four cases. It might be assumed that in cases with hypercoagulability the fibrinolysis reactions were also accelerated.Thromboelastografische Untersuchungen sollten nachweisen welche allgemeine und lokale Faktoren auf den Schwund des Koagulums nach Zahnextraktion Einfluss haben. Diese Untersuchungen wurden an 13 Patienten ausgeführt, darunter bei fünf mit verlängerter Blutgerinnungszeit, während bei acht entzündliche Komplikationen der Alveole zu verzeichnen waren. Die Resultate der thromboelastografischen Messungen weisen darauf hin, dass die Veränderungen in der Wunde nach Zahnextraktion die Folge von lokalen Faktoren, und zwar Trauma, Speichel, Infektion, sind und nicht auf Veränderungen im allgemeinen System der Koagulation und der Fibrinolyse, zuruckzuführen sind. Tromboelastogarmme zeigten in neun Fällen eine hyperkoagulabile Blutreaktion, bloss in vier Fällen eine Normokoagulabilität. Man könte sogar voraussetzen, dass sogar bei Hyperkoagulabilität die Reaktion der Fibrinolyse beschleunigt war

Predictors of Aggressive Behaviour in Children with Autism Spectrum Disorder

Introduction: Aggressive behaviour is not the main symptom of autism spectrum disorders, and if it occurs in this population, it is a consequence of some other factors. Objectives: With regard to that, the aim of this paper is to determine to what extent certain aspects of executive functions, severity of autism, sleep habits, and parenting actions contribute to the manifestation of different forms of aggressive behaviour in children with an autism spectrum disorder. Methods: The sample included 40 children with autism spectrum disorders, 5-7 years of age (M=6.18, SD= .55). The following instruments were used in the assessment: The Children’s Scale of Hostility and Aggression – Reactive/Proactive, Gilliam Autism Rating Scale – Third Edition, The Children’s Sleep Habits Questionnaire and Behavior Rating Inventory of Executive Function. Results: The obtained results showed that sleep problems were the most significant predictor of verbal, physical and covert aggression. From the domain of behavioural aspects of executive functions, only task monitor was a significant predictor of bullying, and inhibit and shift were significant predictors of hostility. From the field of autistic disorders, significant predictors of aggressive behaviour were emotional responses (as predictors of bullying, covert aggression and hostility), and maladaptive speech (as a predictor of verbal aggression, covert aggression and hostility). Punitive discipline was a significant factor only in explaining verbal aggression. Conclusion: Practical implications of this research indicate that, in treating aggressive behaviour in children with ASD, more attention should be paid to sleep habits, practising task monitor, inhibit and shift skills, and avoiding rigorous punitive measures

Hypolipidemic and antioxidant effects of buckwheat leaf and flower mixture in hyperlipidemic rats

As a source of biologically active compounds, buckwheat has beneficial effects in nutrition due to its high content of flavonoids, particularly rutin. Aim of our study was to examine effects of buckwheat on plasma lipid status and phospholipids fatty acids composition, histological and parameters of oxidative stress in Wistar rats fed a high-fat diet. This study showed that buckwheat leaf and flower (BLF) mixture supplementation significantly reduce weight gain, plasma lipid concentrations and atherogenic index in rats fed a high-fat diet. Treatment of the high-fat group of animals with buckwheat significantly increased percentage of n-6 fatty acids as well as eicosapentaenoic acid (EPA) and decreased percentage of saturated fatty acids (SPA) and oleic acid. Buckwheat antioxidant effects diminished negative influence of high-fat diet in hyperlipidemic rats, while pathohistological analysis of liver confirmed changes after high-fat consumption. Our results showed hypolipidemic, antiatherogenic and antioxidative features of buckwheat leaf and flower mixture, and these parts of the plant with the highest rutin content could be beneficial in prevention and curing of hyperlipidemia

Determination of biological activity of protein component in milk, modified for infant feeding, by pepsin-pancreatin digest index

Kao alternativa humanom mlijeku, u slučajevima kada majka ne može da hrani dijete vlastitim mlijekom, danas se u svijetu koristi najčešće kravlje mlijeko čiji je sastav modificiran da bi se približio sastavu humanog mlijeka. Kravlje mlijeko ima 3,5 puta više proteina od humanog mlijeka; osim toga u sastavu proteina kravljeg mlijeka nalazi se 79% kazeina i 21% serum proteinu, a u proteinima humanog mlijeka 35% kazeina i 65% serum proteina. Sastav serum proteina također nije identičan. U skladu sa ovim razlikuje se i amino-kiselinski sastav navedenih proteina i njihova biološka vrijednost. Cilj ovog rada bio je ispitivanje biološke aktivnosti modificiranih proteina u smjeru kazein-serum protein u proizvodnji "infant formula" pepsin-pankreatin testom. Ustanovljeno je utoliko veće povećanje aktivnosti ukoliko je sustav bliži proteinu humanog mlijeka.This study was carried out with the aim to determine biological activity of milk proteins, modified to supstitute human milk proteins in infant formulae, by pepsin-pancreatin digest index. The better biological activity was obtained by samples with higher simmilarity of modified milk proteins to human milk proteins

A New Aculodes Species (Prostigmata: Eriophyidae) Described from an Invasive Weed by Morphological, Morphometric and DNA Barcode Analyses †

A new species of eriophyoid mite, Aculodes marcelli sp. nov., was discovered on cheatgrass, Anisantha tectorum (L.) Nevski (syn. Bromus tectorum L.), an annual grass that is native to Eurasia and Northern Africa. This grass was introduced to North America near the end of the 19th century and now is widespread and associated with the observed increases in the size, frequency, and intensity of wildfires in western N. America. In this paper, A. marcelli sp. nov., is morphologically described and illustrated. Compared with other Aculodes spp., it differs based on morphology and the sequence of the mitochondrial cytochrome oxidase gene, subunit I (MT-CO1). Results of morphometric analysis showed clear differentiation between A. marcelli sp. nov., and the most similar congener, A. altamurgiensis from Taeniatherum caput-medusae. Analysis of MT-CO1 sequence divergence revealed significant levels of genetic variation (17.7%) and supported the results from the morphometric analysis; therefore, it is determined that they are two different species. Aculodes marcelli sp. nov., is a new candidate agent for classical biological control of A. tectorum. © 2022 by the authors

Analiza dinamičkih parametara liftova sa rešenjem zbirne akvizicije podataka tokom eksperimentalnih istraživanja

Modelling of the dynamic behaviour of elevators with high lifting velocities (contemporary elevators in building construction and mine elevators) is a complex task and an important step in the design process and creating conditions for safe and reliable exploitation of these machines. Due to high heights and lifting velocities, the standard procedures for dynamic exploitation are not adequate. With the purpose of identifying the basic parameters of the dynamic model (stiffness and damping), a unique method was applied, based on experimental measures for a concrete elevator. Due to the verification of this procedure, the experiment was conducted on a mine elevator in RTB Bor, Serbia. Simulations of the dynamic behaviour of an empty and loaded cage are presented using the obtained computational-experimental results.Publishe

CARD15 gene polyrnorphisms in Serbian patients with Crohn's disease: genotype-phenotype analysis

Objective Genetic heterogeneity and incomplete phenotype penetrance complicate genetic analysis of Crohn's disease (M. Studies in western Europe have shown that CARD15 polymorphisms increase susceptibility to CD, but frequencies vary within different European populations. The aim here was to evaluate the prevalence of CARD15 mutations and their phenotypic correlation in a Serbian population. Materials and methods 131 patients with CD, 65 patients with ulcerative colitis, and 88 healthy controls were genotyped for three common mutations (R702W, G908R, Leu1007insC) by PCR-restriction fragment length polymorphism. chi(2) and Student's t-test were used for statistical assessment. Results At least one CARD15 disease-associated allele was found in 35.11 % patients with CD, 14.77% of healthy controls (P=0.001), and 7.69% patients with ulcerative colitis (P= 0.0001). The L1007fs mutation showed a significant association with CD (P lt 0.0001). The frequency of R702W mutant allele was almost equal in the control group and CD patients Univariate analyses established that CARD15 carriers had a significantly higher risk of isolated ileal location [P=0.042; odds ratio (OR) 2.30; 95% confidence interval (CI): 1.02-5.191, fibrostenotic behavior (P lt 0.0001; OR 9.86; 95% CI: 4.29-22.62), surgical resection (P=0.036; OR 2.2; CI, 1.046-4.626), and earlier onset of disease (P=0.026). Conclusion This study confirms that CARD15 carriers, especially L1007fs mutants, in central Europeans have an increased risk of CD and it is associated with earlier onset, ileal, fibrostenotic disease and a higher risk of surgery. Any influence of latitude is not matched by an east-west divide on the genotype frequency and phenotype of CD within Europe