14,898 research outputs found
Branching Asymptotics on Manifolds with Edge
We study pseudo-differential operators on a wedge with continuous and
variable discrete branching asymptotics.Comment: 54 pages, 1 figure
Some distance bounds of branching processes and their diffusion limits
We compute exact values respectively bounds of "distances" - in the sense of
(transforms of) power divergences and relative entropy - between two
discrete-time Galton-Watson branching processes with immigration GWI for which
the offspring as well as the immigration is arbitrarily Poisson-distributed
(leading to arbitrary type of criticality). Implications for asymptotic
distinguishability behaviour in terms of contiguity and entire separation of
the involved GWI are given, too. Furthermore, we determine the corresponding
limit quantities for the context in which the two GWI converge to Feller-type
branching diffusion processes, as the time-lags between observations tend to
zero. Some applications to (static random environment like) Bayesian decision
making and Neyman-Pearson testing are presented as well.Comment: 45 page
Picosencond lifetimes and efficient decay channels of vibrational modes of polyatomic molecules in liquids
A picosecond Raman technique with resolution four times better than obtained by spontaneos Raman spectroscopy
CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine
The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the impact of genetics on disease development by enabling the creation of precise cellular and animal models of human diseases. The therapeutic potential of these technologies is tremendous, particularly in gene therapy, in which a patient-specific mutation is genetically corrected in order to treat human diseases that are untreatable with conventional therapies. However, the translation of CRISPR/Cas9 into the clinics will be challenging, since we still need to improve the efficiency, specificity and delivery of this technology. In this review, we focus on several in vitro, in vivo and ex vivo applications of the CRISPR/Cas9 system in human disease-focused research, explore the potential of this technology in translational medicine and discuss some of the major challenges for its future use in patients.Portuguese Foundation for Science and Technology:
UID/BIM/04773/2013
1334
Spanish Ministry of Science, Innovation and Universities
RTI2018-094629-B-I00
Portuguese Foundation for Science and Technology
SFRH/BPD/100434/2014
European Union (EU)
748585
LPCC-NRS/Terry Fox grantsinfo:eu-repo/semantics/publishedVersio
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