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Layered Fabrication of Branched Networks Using Lindenmayer Systems
A current challenge impeding the growth of bone tissue engineering is the lack of
functional scaffolds of geometric sizes greater than 10mm due to the inability of cells to
survive deep within the scaffold. It is hypothesized that these scaffolds must have an
inbuilt nutrient distribution network to sustain the uniform growth of cells. In this
paper, we seek to enhance the design and layered fabrication of scaffold internal
architecture through the development of Lindenmayer systems, a graphical language
based theory to create nutrient delivery networks. The scaffolds are fabricated using the
Texas Instruments DLP™ system through UV‐photopolymerization to produce
polyethylene glycol hydrogels with internal branch structures. The paper will discuss
the Lindenmayer system, process planning algorithms, layered fabrication of samples,
challenges and future tasks.Mechanical Engineerin
Regulating the Energy Flow in a Cyanobacterial Light Harvesting Antenna Complex
Photosynthetic organisms harvest light energy, utilizing the absorption and
energy transfer properties of protein-bound chromophores. Controlling the
harvesting efficiency is critical for the optimal function of the
photosynthetic apparatus. Here, we show that cyanobacterial light-harvesting
antenna may be able to regulate the flow of energy in order to switch
reversibly from efficient energy conversion to photo-protective quenching via a
structural change. We isolated cyanobacterial light harvesting proteins,
phycocyanin and allophycocyanin, and measured their optical properties in
solution and in an aggregated-desiccated state. The results indicate that
energy band structures are changed, generating a switch between two modes of
operation: exciton transfer and quenching; achieved without dedicated
carotenoid quenchers. This flexibility can contribute greatly to the large
dynamic range of cyanobacterial light harvesting systems.Comment: Published at J. Phys. Chem.
Relationshiop Between Ploidal Level and Cam in Five Species of Talinum (Portulacaceae)
This is the publisher's offical version, also available electronically from: http://www.jstor.org/stable/2445368
WIC Participation as a Risk Factor for Loss to Follow-Up in the Wisconsin EHDI System
In 2011, Wisconsin’s Early Hearing Detection and Intervention (EHDI) program, Wisconsin Sound Beginnings (WSB), developed multiple strategies to reduce loss to follow-up (LTFU) for babies who did not pass their newborn hearing screening: Medical Outreach, Family Outreach, Regional Outreach and WIC Alert. WSB evaluated the outcomes of babies identified as at-risk for LTFU to determine whether WIC participation was an indicator of their risk for LTFU. Additionally, WSB evaluated whether babies who were identified as at-risk for LTFU and receiving WIC services in two WIC projects serving areas and populations with known health disparities, were at even greater risk for LTFU. WSB found no statistically significant differences in outcomes between babies who were WIC participants and those who were not. This paper discusses implications of this research for other EHDI programs
Polysaccharide utilization loci and nutritional specialization in a dominant group of butyrate-producing human colonic Firmicutes
Acknowledgements The Rowett Institute of Nutrition and Health (University of Aberdeen) receives financial support from the Scottish Government Rural and Environmental Sciences and Analytical Services (RESAS). POS is a PhD student supported by the Scottish Government (RESAS) and the Science Foundation Ireland, through a centre award to the APC Microbiome Institute, Cork, Ireland. Data Summary The high-quality draft genomes generated in this work were deposited at the European Nucleotide Archive under the following accession numbers: 1. Eubacterium rectale T1-815; CVRQ01000001–CVRQ0100 0090: http://www.ebi.ac.uk/ena/data/view/PRJEB9320 2. Roseburia faecis M72/1; CVRR01000001–CVRR010001 01: http://www.ebi.ac.uk/ena/data/view/PRJEB9321 3. Roseburia inulinivorans L1-83; CVRS01000001–CVRS0 100 0151: http://www.ebi.ac.uk/ena/data/view/PRJEB9322Peer reviewedPublisher PD
Implication of Complement System and its Regulators in Alzheimer’s Disease
Alzheimer’s disease (AD) is an age-related neurodegenerative disease that affects approximately 24 million people worldwide. A number of different risk factors have been implicated in AD, however, neuritic (amyloid) plaques are considered as one of the defining risk factors and pathological hallmarks of the disease. Complement proteins are integral components of amyloid plaques and cerebral vascular amyloid in Alzheimer brains. They can be found at the earliest stages of amyloid deposition and their activation coincides with the clinical expression of Alzheimer's dementia. This review emphasizes on the dual key roles of complement system and complement regulators (CRegs) in disease pathology and progression. The particular focus of this review is on currently evolving strategies for design of complement inhibitors that might aid therapy by restoring the fine balance between activated components of complement system, thus improving the cognitive performance of patients. This review discusses these issues with a view to inspiring the development of new agents that could be useful for the treatment of AD
Finite-size scaling analysis of the distributions of pseudo-critical temperatures in spin glasses
Using the results of large scale numerical simulations we study the
probability distribution of the pseudo critical temperature for the
three-dimensional Edwards-Anderson Ising spin glass and for the fully connected
Sherrington-Kirkpatrick model. We find that the behavior of our data is nicely
described by straightforward finite-size scaling relations.Comment: 23 pages, 9 figures. Version accepted for publication in J. Stat.
Mec
Electronic, vibrational, and thermodynamic properties of ZnS (zincblende and rocksalt structure)
We have measured the specific heat of zincblende ZnS for several isotopic
compositions and over a broad temperature range (3 to 1100 K). We have compared
these results with calculations based on ab initio electronic band structures,
performed using both LDA and GGA exchange- correlation functionals. We have
compared the lattice dynamics obtained in this manner with experimental data
and have calculated the one-phonon and two-phonon densities of states. We have
also calculated mode Grueneisen parameters at a number of high symmetry points
of the Brillouin zone. The electronic part of our calculations has been used to
investigate the effect of the 3d core electrons of zinc on the spin-orbit
splitting of the top valence bands. The effect of these core electrons on the
band structure of the rock salt modification of ZnS is also discussed.Comment: 33pages, 16 Figures, submitted to Phys. Rev.
Chandra Discovery of a 300 kpc X-ray Jet in the GPS Quasar PKS1127-145
We have discovered an X-ray jet with Chandra imaging of the z=1.187
radio-loud quasar PKS1127-145. In this paper we present the Chandra X-ray data,
follow-up VLA observations, and optical imaging using the HST WFPC2. The X-ray
jet contains 273+/-5 net counts in 27ksec and extends ~30 arcsec, from the
quasar core, corresponding to a minimum projected linear size of ~330/h_50 kpc.
The evaluation of the X-ray emission processes is complicated by the observed
offsets between X-ray and radio brightness peaks. We discuss the problems posed
by these observations to jet models. In addition, PKS1127-145 is a Giga-Hertz
Peaked Spectrum radio source, a member of the class of radio sources suspected
to be young or ``frustrated'' versions of FRI radio galaxies. However the
discovery of an X-ray and radio jet extending well outside the host galaxy of
PKS1127-145 suggests that activity in this and other GPS sources may be
long-lived and complex.Comment: 22 pages, 11 ps figures, 1 figure in a JPG file, 3 tables. AASTEX.
Accepted by The Astrophysical Journa
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