44 research outputs found

    Editorial

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    Caso piloto panorama tecnológico del café al 2030 prospectiva tecnológica

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    Estudio de prospectiva, vigilancia e inteligencia organizacional en el que se presenta el posible escenario del sector caficultor en Colombia a la década 2030 que permita establecer políticas y planes de inversión e identificar tendencias que favorezcan la actuación y toma de decisiones por parte del SENA para minimizar el riesgo de error en las acciones de la entidad.Prospective study, surveillance and organizational intelligence in which the possible scenario of the coffee sector in Colombia is presented to the decade 2030 that allows to establish policies and investment plans and identify trends that favor the action and decision making by SENA to minimize the risk of error in the actions of the entity.Fase 1-pre-prospectiva -- Fase 2-prospectiva -- Análisis estratégico del entorno Microcultura -- Vigilancia científica-tecnológica (base de datos scopus) -- Vigilancia competitiva -- Generalidades del café -- Contexto del mercado Cafetero internacional y nacional -- Balanza/saldo comercial de 20 países nivel mundial 2007-2016136 página

    Laboratorios abiertos: una propuesta para la mejora del perfil de ingreso y la captación de estudiantes desde la facultad de química de la UMU

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    [SPA]Durante los últimos años ha disminuido de forma significativa el número de estudiantes universitarios de ciencias e ingenierías mientras que la sociedad europea demanda un mayor número de este tipo de profesionales. La mejora del perfil de ingreso en los estudios científicos y la captación de alumnos para los mismos son aspectos fundamentales en la actualidad para desarrollar estas enseñanzas. En este marco la Facultad de Química de la UMU ha diseñado una propuesta divulgativa y de acercamiento de la Física y de la Química, organizando una Jornada en la que alumnos de bachillerato realizan una serie de experiencias prácticas en sus laboratorios. La experiencia se ha evaluado a través de tres cuestionarios durante las diferentes ediciones de la actividad para reunir información acerca del perfil de los alumnos y su valoración de las actividades. [ENG]During last years the number of university students in science and engineering has significantly decreased while the european society demands a greater number of these professionals. Nowadays, to improve the level in scientific studies and the recruitment of student are fundamentals to develop the grade studies. In this context, the Chemistry Faculty of University of Murcia prepared a Conference of Physics and Chemistry in which high school student performed a series of practical experiment in their laboratories. The experience was evaluated through different questionnaires to gather information about the profile of student and their assessment of the activities.Campus Mare Nostrum, Universidad Politécnica de Cartagena, Universidad de Murcia, Región de Murci

    Lecciones de filosofía

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    Lecciones de filosofía es el resultado de un curso de introducción a la filosofía impartido por el equipo docente e investigativo del Departamento de Filosofía de la Universidad Nacional de Colombia a estudiantes del Doctorado y de la Maestría en Derecho. / Contenido. Preliminares; Capítulo 1 - Filosofía antigua; Capítulo 2 - Filosofía moderna; Capítulo 3 - Filosofía contemporánea; Anexos

    Late-onset thymidine kinase 2 deficiency: a review of 18 cases

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    Background: TK2 gene encodes for mitochondrial thymidine kinase, which phosphorylates the pyrimidine nucleosides thymidine and deoxycytidine. Recessive mutations in the TK2 gene are responsible for the ‘myopathic form’ of the mitochondrial depletion/multiple deletions syndrome, with a wide spectrum of severity. Methods: We describe 18 patients with mitochondrial myopathy due to mutations in the TK2 gene with absence of clinical symptoms until the age of 12. Results: The mean age of onset was 31 years. The first symptom was muscle limb weakness in 10/18, eyelid ptosis in 6/18, and respiratory insufficiency in 2/18. All patients developed variable muscle weakness during the evolution of the disease. Half of patients presented difficulty in swallowing. All patients showed evidence of respiratory muscle weakness, with need for non-invasive Mechanical Ventilation in 12/18. Four patients had deceased, all of them due to respiratory insufficiency. We identified common radiological features in muscle magnetic resonance, where the most severely affected muscles were the gluteus maximus, semitendinosus and sartorius. On muscle biopsies typical signs of mitochondrial dysfunction were associated with dystrophic changes. All mutations identified were previously reported, being the most frequent the in-frame deletion p.Lys202del. All cases showed multiple mtDNA deletions but mtDNA depletion was present only in two patients. Conclusions: The late-onset is the less frequent form of presentation of the TK2 deficiency and its natural history is not well known. Patients with late onset TK2 deficiency have a consistent and recognizable clinical phenotype and a poor prognosis, due to the high risk of early and progressive respiratory insufficiency

    Cerebral Anatomy of the Spider Monkey Ateles Geoffroyi Studied Using Magnetic Resonance Imaging. First Report: a Comparative Study with the Human Brain Homo Sapiens

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    El objetivo del presente estudio cualitativo fue analizar los aspectos morfológicos de la anatomía cerebral interna utilizando imágenes de resonancia magnética (IRM) en dos especies de primates, El mono Araña (A. geoffroyi) y el humano (H. sapiens), tomando como base un estudio comparativo de las estructuras cerebrales de las dos especies, concentrándose primordialmente en el sistema límbico del cerebro del mono araña. Aunque es una especie común en el hemisferio occidental, es interesante para estudiar dada su organización social y funciones motoras, el mono araña (A. geoffroyi) ha sido poco estudiado en cuanto a su neuroanatomía. Las IRM fueron hechas a un mono araña utilizando un resonador General Electrics Signa 1.5 T. Esta investigación se llevo a cabo conforme a las leyes internacionales para la protección de animales en cautiverio y teniendo en cuenta todas las medidas de protección para el manejo experimental para evitar cualquier efecto residual de índole comportamental o fisiológico. Desde un punto de vista cualitativo, los cerebros del mono araña y el humano tenían estructuras similares. Con respecto a la forma, las estructuras más parecidas fueron encontradas en el sistema límbico, sin embargo la curvatura cervical, la amígdala, el hipocampo, la comisura anterior y el colículo fueron más grandes proporcionalmente en el mono araña que en el humano.The objective of the present qualitative study was to analyze the morphological aspects of the inner cerebral anatomy of two species of primates, using magnetic resonance images (MRI): spider monkey (A. geoffroyi) and human (H. sapiens), on the basis of a comparative study of the cerebral structures of the two species, focusing upon the brain of the spider monkey and, primarily, its limbic system. In spite of being an endemic Western hemisphere species, a fact which is by its own right interesting for research due to this animal’s social organization and motor functions, the spider monkey (A. geoffroyi) has hardly been studied in regard to its neuroanatomy. MRI was carried out, in one spider monkey, employing a General Electric Signa 1.5 T scanner. This investigation was carried in accordance to international regulations for the protection of animals in captivity, taking into account all protective means utilized in experimental handling, and not leaving behind any residual effects, either physiological or behavioral. From a qualitative point of view, the brains of the spider monkey and the human were found to have similar structures. In reference to shape, the most similar structures were found in the limbic system; proportionally, however, cervical curvature, amygdala, hippocampus, anterior commissure and the colliculi, were larger in the spider monkey than in the human

    Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

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    Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation

    Construcción, caracterización y puesta a punto de un microscopio de efecto tunel : aplicación al estudio de superficies en un proceso de metalizado de plásticos / Aurelio Arenas Dallas Vecchia ; director Fco. Javier Abellán García.

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    Tesis-Universidad de Murcia.Consulte la tesis en: BCA. GENERAL. ARCHIVO UNIVERSITARIO. T.M.-1060.CRAI CIENCIAS. DEPOSITO. T.D. 170

    Sensibilicémonos desde el arte

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    Ubicación en Biblioteca USB Medellín (Campus): CD-2153tEste proyecto surge debido a las problemáticas existentes en los sujetos des escolarizados, que habitan el entorno de la I.E Pequeña María como: la falta de comprensión de los y las estudiantes frente a sus entornos, ya sea escolar o en casa, la parte con vivencial tanto con sus compañeros como con hermanos y familiares, no dan cuenta de su propia responsabilidad en las relaciones interpersonales y es evidente su agresividad en descansos y en el aula de clase, también las falencias en procesos académicos, como la lectura y la escritura; de allí las dificultades para comunicarse
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