3,254 research outputs found
New Physics at the International Facility for Antiproton and Ion Research (FAIR) Next to GSI
The project of the international Facility for Antiproton and Ion Research
(FAIR), co-located to the GSI facility in Darmstadt, has been officially
started on November 7, 2007. The current plans of the facility and the planned
research program will be described. An investment of about 1 billion euro will
permit new physics programs in the areas of low and medium energy antiproton
research, heavy ion physics complementary to LHC, as well as in nuclear
structure and astrophysics. The facility will comprise about a dozen
accelerators and storage rings, which will enable simultaneous operations of up
to four different beams.Comment: 7 pages, 1 figure. Invited Talk presented at the "Fourth
International Conference on Fission and Properties of Neutron-Rich nuclei",
held at Sanibel Island, Florida, November 11-17, 200
Restriction on the energy and luminosity of e+e- storage rings due to beamstrahlung
The role of beamstrahlung in high-energy e+e- storage-ring colliders (SRCs)
is examined. Particle loss due to the emission of single energetic
beamstrahlung photons is shown to impose a fundamental limit on SRC
luminosities at energies 2E_0 >~ 140 GeV for head-on collisions and 2E_0 >~ 40
GeV for crab-waist collisions. With beamstrahlung taken into account, we
explore the viability of SRCs in the E_0=240-500 GeV range, which is of
interest in the precision study of the Higgs boson. At 2E_0=240 GeV, SRCs are
found to be competitive with linear colliders; however, at 2E_0=400-500 GeV,
the attainable SRC luminosity would be a factor 15-25 smaller than desired.Comment: Latex, 5 pages. v2 differs only by minor changes is abstract and
introduction, one reference is added. v3 corresponds to the paper published
in PR
Next Generation Sequencing Assay for Detection of Circulating HPV DNA (cHPV-DNA) in Patients Undergoing Radical (Chemo)Radiotherapy in Anal Squamous Cell Carcinoma (ASCC).
Background: Following chemo-radiotherapy (CRT) for human papilloma virus positive (HPV+) anal squamous cell carcinoma (ASCC), detection of residual/recurrent disease is challenging. Patients frequently undergo unnecessary repeated biopsies for abnormal MRI/clinical findings. In a pilot study we assessed the role of circulating HPV-DNA in identifying "true" residual disease. Methods: We prospectively collected plasma samples at baseline (n = 21) and 12 weeks post-CRT (n = 17). Circulating HPV-DNA (cHPV DNA) was measured using a novel next generation sequencing (NGS) assay, panHPV-detect, comprising of two primer pools covering distinct regions of eight high-risk HPV genomes (16, 18, 31, 33, 35, 45, 52, and 58) to detect circulating HPV-DNA (cHPV DNA). cHPV-DNA levels post-CRT were correlated to disease response. Results: In pre-CRT samples, panHPV-detect demonstrated 100% sensitivity and specificity for HPV associated ASCC. PanHPV-detect was able to demonstrate cHPV-DNA in 100% (9/9) patients with T1/T2N0 cancers. cHPV-DNA was detectable 12 weeks post CRT in just 2/17 patients, both of whom relapsed. 1/16 patients who had a clinical complete response (CR) at 3 months post-CRT but relapsed at 9 months and 1/1 patient with a partial response (PR). PanHPV-detect demonstrated 100% sensitivity and specificity in predicting response to CRT. Conclusion: We demonstrate that panHPV-detect, an NSG assay is a highly sensitive and specific test for the identification of cHPV-DNA in plasma at diagnosis. cHPV-DNA post-treatment may predict clinical response to CRT
EXTENDING THE INDUCTION PERIOD OF CRYSTALLIZATION FOULING THROUGH SURFACE COATING
To minimize the negative effects of scale formation in heat exchangers, new anti-fouling strategies are focusing on the modification of heat transfer surfaces. These modifications should lead to tailored made surfaces for different technical applications. Aim of this surface modification is the extension of the induction period to minimize the negative effects of fouling and maximize the endurance of the heat exchanger. To achieve such, different surface coatings on stainless steel were investigated in respect of fouling tendency. The effect of flow velocity respectively Reynolds number on the induction time of CaSO4 crystallization fouling were tested in different test units. Diamond like carbon coatings are extending the induction time in every measured flow velocity. At higher Reynolds numbers, the effect of different surface crystallization due to energetic modification is reduced because of the dominating effect of the low adhesive surface. Thus the induction time can be extended by the factor of 2 for low fluid velocities (DLC or SICON®) and more than 20 for higher Reynolds numbers (DLC and SICON®). The combination of limited nucleation spots due to electro-chemical treatment of the substrate before coating can be a tailored made surface with maximum induction time for crystallization fouling
Irradiation study of a fully monolithic HV-CMOS pixel sensor design in AMS 180 nm
High-Voltage Monolithic Active Pixel Sensors (HV-MAPS) based on the 180 nm
HV-CMOS process have been proposed to realize thin, fast and highly integrated
pixel sensors. The MuPix7 prototype, fabricated in the commercial AMS H18
process, features a fully integrated on-chip readout, i.e. hit-digitization,
zero suppression and data serialization. It is the first fully monolithic
HV-CMOS pixel sensor that has been tested for the use in high irradiation
environments like HL-LHC. We present results from laboratory and test beam
measurements of MuPix7 prototypes irradiated with neutrons (up to
) and protons (up to ) and compare the performance with non-irradiated
sensors. Efficiencies well above 90 % at noise rates below 200 Hz per pixel are
measured. A time resolution better than 22 ns is measured for all tested
settings and sensors, even at the highest irradiation fluences. The data
transmission at 1.25 Gbit/s and the on-chip PLL remain fully functional
A formal MIM specification and tools for the common exchange of MIM diagrams: an XML-Based format, an API, and a validation method
<p>Abstract</p> <p>Background</p> <p>The Molecular Interaction Map (MIM) notation offers a standard set of symbols and rules on their usage for the depiction of cellular signaling network diagrams. Such diagrams are essential for disseminating biological information in a concise manner. A lack of software tools for the notation restricts wider usage of the notation. Development of software is facilitated by a more detailed specification regarding software requirements than has previously existed for the MIM notation.</p> <p>Results</p> <p>A formal implementation of the MIM notation was developed based on a core set of previously defined glyphs. This implementation provides a detailed specification of the properties of the elements of the MIM notation. Building upon this specification, a machine-readable format is provided as a standardized mechanism for the storage and exchange of MIM diagrams. This new format is accompanied by a Java-based application programming interface to help software developers to integrate MIM support into software projects. A validation mechanism is also provided to determine whether MIM datasets are in accordance with syntax rules provided by the new specification.</p> <p>Conclusions</p> <p>The work presented here provides key foundational components to promote software development for the MIM notation. These components will speed up the development of interoperable tools supporting the MIM notation and will aid in the translation of data stored in MIM diagrams to other standardized formats. Several projects utilizing this implementation of the notation are outlined herein. The MIM specification is available as an additional file to this publication. Source code, libraries, documentation, and examples are available at <url>http://discover.nci.nih.gov/mim</url>.</p
MuPix7 - A fast monolithic HV-CMOS pixel chip for Mu3e
The MuPix7 chip is a monolithic HV-CMOS pixel chip, thinned down to 50 \mu m.
It provides continuous self-triggered, non-shuttered readout at rates up to 30
Mhits/chip of 3x3 mm^2 active area and a pixel size of 103x80 \mu m^2. The hit
efficiency depends on the chosen working point. Settings with a power
consumption of 300 mW/cm^2 allow for a hit efficiency >99.5%. A time resolution
of 14.2 ns (Gaussian sigma) is achieved. Latest results from 2016 test beam
campaigns are shown.Comment: Proceedingsfor the PIXEL2016 conference, submitted to JINST A
dangling reference has been removed from this version, no other change
The MuPix Telescope: A Thin, high Rate Tracking Telescope
The MuPix Telescope is a particle tracking telescope, optimized for tracking
low momentum particles and high rates. It is based on the novel High-Voltage
Monolithic Active Pixel Sensors (HV-MAPS), designed for the Mu3e tracking
detector. The telescope represents a first application of the HV-MAPS
technology and also serves as test bed of the Mu3e readout chain. The telescope
consists of up to eight layers of the newest prototypes, the MuPix7 sensors,
which send data self-triggered via fast serial links to FPGAs, where the data
is time-ordered and sent to the PC. A particle hit rate of 1 MHz per layer
could be processed. Online tracking is performed with a subset of the incoming
data. The general concept of the telescope, chip architecture, readout concept
and online reconstruction are described. The performance of the sensor and of
the telescope during test beam measurements are presented.Comment: Proceedings TWEPP 2016, 8 pages, 7 figure
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