Global Thrombosis Test - a possible monitoring system for the effects and safety of dabigatran

© Otsui et al. 2015BACKGROUND: Dabigatran is an alternative to warfarin (WF) for the thromboprophylaxis of stroke in patients with non-valvular atrial fibrillation (NVAF). The advantage of dabigatran over WF is that monitoring is not required; however, a method to monitor the effect and the safety of dabigatran is not currently available. The Global Thrombosis Test (GTT) is a novel method to assess both clot formation and lysis activities under physiological conditions. OBJECTIVE: The aim of this study was to evaluate whether treatment with dabigatran might affect shear-induced thrombi (occlusion time [OT], sec) by the GTT, and to investigate the possibility that the GTT could be useful as a monitoring system for dabigatran. PATIENTS/METHODS: The study population consisted of 50 volunteers and 43 NVAF patients on WF therapy, who were subsequently switched to dabigatran. Using the GTT, the thrombotic status was assessed one day before and 1 month after switching anticoagulation from WF to dabigatran. RESULTS: The OT was 524.9 ± 17.0 sec in volunteers whereas that of NVAF patients on WF therapy was 581.7 ± 26.3 sec. The switch from WF to dabigatran significantly prolonged OT (784.5 ± 19.3 sec). One patient on WF therapy and 12 patients on dabigatran therapy were shown to have OT > 900 sec. CONCLUSION: The GTT could be used to assess the risk of dabigatran-related bleeding complications.Peer reviewe

Physiological Markers of Motor Improvement Following Five-month Sprint Training in Young Boys

The 11th International Symposium on Adaptive Motion of Animals and Machines. Kobe University, Japan. 2023-06-06/09. Adaptive Motion of Animals and Machines Organizing Committee.Poster Session P4

ホケンカンリセンター ノ アリカタ ダイニホウ ガクセイ ノ コエ カラ ガクセイシエンセンター ヲ カンガエル

It is not so difficult that we can find students who don\u27t have adaptation such as are inactive,easily depressed and become to be irritated when things are notwell done.They visited support center in order to consult with us,with anxieties of human relation and study.Support center analyzes students who visited here and search what they want for us.Trying to listen to students and face to face with them,we counsel them on the matter of health.On the other hands, student\u27s problems increased and they are complicated.This study examines what support center should be and how to manage it

ホケンキョウイク ト キンエンカツドウ

Closing of smoking area, nonsmoking has been conducted from 4 years ago in our college site. Our college has been promoted to stop smoking in college site in order to keep student\u27s health and nurture teachers for children\u27s lives and health. In spite of our expectations, smoking students didn\u27t decrease and made new problems in habitual bad manners around adjacent area.Through questionnaire for not only students but also teachers, we carried out the research for consciousness of nonsmoking, defined problem and study for health education and nonsmoking activity in future

Pharmacokinetics and pharmacodynamics of recombinant soluble thrombomodulin in disseminated intravascular coagulation patients with renal impairment

Recombinant human soluble thrombomodulin (TM-α) was recently developed as an anticoagulant for patients with disseminated intravascular coagulation (DIC). However, the pharmacokinetics and pharmacodynamics of TM-α in DIC patients with severe renal impairment have not yet been elucidated. We investigated the pharmacokinetics and pharmacodynamics of TM-α in DIC patients with severe renal impairment. Eleven DIC patients with the severe renal impairment (creatinine clearance (CLcr) <30 ml/min) and 10 DIC patients without severe renal impairment (CLcr ≥ 30 ml/min) were included in this study. In all patients, a dose of 380 U/kg of TM-α was administered during a 30 min infusion. Blood samples were taken before the start of the first TM-α administration, and at 0.5, 2, 4, 8, and 24 h after the start of administration. Although the clearance of TM-α in the patients with renal impairment was 80% of that in the patients without renal impairment, none of the pharmacokinetic values were significantly different between the groups. In the pharmacokinetic simulation, however, the trough levels of TM-α increased gradually in the patients with renal impairment when the same dose of TM-α was repeatedly administered. After the administration of TM-α, the prothrombinase activities in the patients in both groups were sufficiently inhibited during the observation period. Although the pharmacokinetic values in DIC patients with severe renal impairment were only slightly different from those in DIC patients without severe renal impairment, we need to pay attention to the elevation of the trough levels of TM-α when the same dose of TM-α is repeatedly administered

Differential adaptive responses to 1‐ or 2‐day fasting in various mouse tissues revealed by quantitative PCR analysis

Dietary or caloric restriction confers various clinical benefits. Short‐term fasting of mice is a common experimental procedure that may involve systemic metabolic remodeling, which may significantly affect experimental outputs. This study evaluated adaptive cellular responses after 1‐ or 2‐day fasting in 13 mouse tissues by quantitative PCR using 15 marker primer sets for the activation of ubiquitin–proteasome (Atrogin‐1 andMuRF1), autophagy–lysosome (LC3b,p62 andLamp2), amino acid response (Asns,Trib3,Herpud1,xCT, andChop), Nrf2‐mediated antioxidant (HO‐1 andGsta1), and amino acid transport (Slc38a2,Slc7a5, andSlc7a1) systems. Differential activation profiles obtained in seven highly (thymus, liver, spleen, and small intestine) or mildly (stomach, kidney, and colon) atrophied tissues as well as in six non‐atrophied tissues (brain, eye, lung, heart, skeletal muscle, and testis) suggested tissue‐specific active metabolic remodeling

Analysis of the Timing of Evacuation and Associated Factors Among Home Health Care Patients During Flooding: A Single-Clinic-Based Mixed Methods Study

Home health care patients (HHPs) are vulnerable to flooding and may face evacuation difficulties. Previous studies reported that HHPs and their families are more susceptible to disasters than non-HHPs. Our prior research revealed that many HHPs in Fukui, Japan, were at risk for flooding and landslides, requiring evacuation assistance, yet few were aware of the exact risks. This study analyzed survey data to identify barriers to evacuation during floods and assess the assistance needed among HHPs. A concurrent nested design of mixed-method research was employed. We calculated the percentage of the 87 HHPs at risk likely to delay evacuation and constructed univariable and multivariable logistic regression models to identify factors associated with delayed evacuation, and employed a thematic analysis to identify concerns and needs during evacuation. Family members responded to the questionnaire for patients unable to respond. The study found that 69.0 % of patients delayed evacuation, with 61.7 % incorrectly perceiving disaster risks and 20.0 % considering evacuation unimportant. Those with incorrect risk perceptions were slower to evacuate than those with accurate perceptions (OR: 1.35, 95 % confidence interval: 1.06–6.99, p-value: 0.036). Seven themes about flood preparedness needs were extracted from open-ended statements. Factors contributing to delayed evacuation included assumptions of vertical evacuation due to mobility challenges and concerns about evacuation site environments. Few Japanese HHPs at risk of flooding and landslides would plan an early evacuation, often due to misperceived disaster risks. Specific measures are needed to address these issues, and further investigation is required as flooding may also affect patient supporters