40 research outputs found

    Structural Conditions and Migration in the Dakotas

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    This study examines the influence of selected structural conditions on the county-level net-migration trends of North Dakota and South Dakota. Key principles from Lee’s Theory of Migration (1966) and Wallerstein’s World Systems model (1974) were integrated to explain how geographic context, economic dependency, and pace of economic development combine to serve as the main catalysts behind the migration patterns in these two states. Results indicate that commuting patterns, the percentage of workers employed in extractive industries, the percentage of workers employed in manufacturing, and job change rates were significant predictors of county migration patterns

    Materials Handling—Unit Operations Review

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    Genetic Polymorphisms in ADRB2 and ADRB1 Are Associated with Differential Survival in Heart Failure Patients Taking β-Blocker

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    Single nucleotide polymorphisms (SNPs) have been associated with differential beta-blocker (BB) effects on heart rate, blood pressure, and left ventricular ejection fraction in various patient populations. This study aimed to determine if SNPs previously associated with BB response are also associated with differential survival in heart failure (HF) patients receiving BBs. HF patient data were derived from electronic health records and the Social Security Death Index. Associations and interactions between BB dose, SNP genotype, and the outcome of death were assessed using a Cox proportional-hazard model adjusting for covariates known to be associated with differential survival in HF patients. Two SNPs, ADRB1 Arg389Gly and ADRB2 Glu27Gln, displayed significant interactions (Pint = 0.043 and Pint = 0.017, respectively) with BB dose and their association with mortality. Our study suggests that ADRB2 27Glu and ADRB1 389Arg may confer a larger survival benefit with higher BB doses in patients with HF
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