Normal Subgroups of Classical Groups over von Neumann Regular Rings

AbstractLet R be a von Neumann regular ring. We obtain a complete description of all subgroups of the pseudo-orthogonal groups O2nR for n ≥ 3 which are normalized by elementary orthogonal matrices. We also prove the normality of EO2n(R, J) in O2nR when R is an abelian von Neumann regular ring and n ≥ 1

Electronic Journals: Then and Now...A Fifteen Year Retrospective

pdf documentElectronic Journal history.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/61418/1/ElectronicJournalsSolstice.pd

Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl

Cells from individuals with the recessive cancer-prone disorder ataxia telangiectasia (A-T) are hypersensitive to ionizing radiation (I-R). ATM (mutated in A-T) is a protein kinase whose activity is stimulated by I-R. c-Abl, a nonreceptor tyrosine kinase, interacts with ATM and is activated by ATM following I-R. Rad51 is a homologue of bacterial RecA protein required for DNA recombination and repair. Here we demonstrate that there is an I-R-induced Rad51 tyrosine phosphorylation, and this induction is dependent on both ATM and c-Abl. ATM, c-Abl, and Rad51 can be co-immunoprecipitated from cell extracts. Consistent with the physical interaction, c-Abl phosphorylates Rad51 in vitro and in vivo. In assays using purified components, phosphorylation of Rad51 by c-Abl enhances complex formation between Rad51 and Rad52, which cooperates with Rad51 in recombination and repair. After I-R, an increase in association between Rad51 and Rad52 occurs in wild-type cells but not in cells with mutations that compromise ATM or c-Abl. Our data suggest signaling mediated through ATM, and c-Abl is required for the correct post-translational modification of Rad51, which is critical for the assembly of Rad51 repair protein complex following I-R

Development and characterization of a stable adhesive bond between a poly(dimethylsiloxane) catheter material and a bacterial biofilm resistant acrylate polymer coating

Catheter associated urinary tract infections (CA-UTIs) are the most common health related infections world wide, contributing significantly to patient morbidity and mortality and increased health care costs. To reduce the incidence of these infections, new materials that resist bacterial biofilm formation are needed. A composite catheter material, consisting of bulk PDMS coated with a novel bacterial biofilm resistant polyacrylate (EGDPEA–co-DEGMA) has been proposed. The coated material shows excellent bacterial resistance when compared to commercial catheter materials but delamination of the coatings under mechanical stress presents a challenge. In this work, the use of oxygen plasma treatment to improve the wettability and reactivity of the PDMS catheter material and improve adhesion with the EGDPEA–co-DEGMA coating has been investigated. Argon Cluster 3D-imaging Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) has been used to probe the buried adhesive interface between the EGDPEA–co-DEGMA coating and the treated PDMS. ToF-SIMS analysis was performed in both dry and frozen-hydrated states and results were compared to mechanical tests. From the ToF-SIMS data we have been able to observe the presence of PDMS, silicates, salt particles, cracks and water at the adhesive interface. In the dry catheters, low molecular weight PDMS oligomers at the interface were associated with poor adhesion. When hydrated, the hydrophilic silicates attracted water to the interface and led to easy delamination of the coating. The best adhesion results, under hydrated conditions, were obtained using a combination of 5 min O2 plasma treatment and silane primers. Cryo-ToF-SIMS analysis of the hydrated catheter material showed that the bond between the primed PDMS catheter and the EGDPEA–co-DEGMA coating was stable in the presence of water. The resulting catheter material was resisted Escherichia coli and Proteus mirabilis biofilm colonization by up to 95 % compared with uncoated PDMS after 10 days of continuous bacterial exposure and had the mechanical properties necessary for use as a urinary catheter

uptake, intracellular distribution and cellular responses

Silver nanoparticles (SNP) are among the most commercialized nanoparticles worldwide. They can be found in many diverse products, mostly because of their antibacterial properties. Despite its widespread use only little data on possible adverse health effects exist. It is difficult to compare biological data from different studies due to the great variety in sizes, coatings or shapes of the particles. Here, we applied a novel synthesis approach to obtain SNP, which are covalently stabilized by a small peptide. This enables a tight control of both size and shape. We applied these SNP in two different sizes of 20 or 40 nm (Ag20Pep and Ag40Pep) and analyzed responses of THP-1-derived human macrophages. Similar gold nanoparticles with the same coating (Au20Pep) were used for comparison and found to be non-toxic. We assessed the cytotoxicity of particles and confirmed their cellular uptake via transmission electron microscopy and confocal Raman microscopy. Importantly a majority of the SNP could be detected as individual particles spread throughout the cells. Furthermore we studied several types of oxidative stress related responses such as induction of heme oxygenase I or formation of protein carbonyls. In summary, our data demonstrate that even low doses of SNP exerted adverse effects in human macrophages

2007 Report of the ICES Study Group on Fisheries-Induced Adaptive Change (SGFIAC)

There is a growing body of scientific evidence indicating that fisheries can cause evolutionary responses over time periods as short as 1020 years, in particular in traits such as the onset of maturation. As these changes will most likely result in a reduction of the productivity of a fish stock, management objectives and (precautionary) reference points for sustainable exploitation need to be re-defined, and new objectives and reference points for managing fisheries-induced evolution need to be developed. Current knowledge allows for two generalisations. First, reducing harvest rates will almost always slow the rate and extent of fisheries-induced evolution in most life-history traits. Second, raising a stock's minimum size limit for exploitation well above the size range over which maturation occurs will slow down the rate of evolution in its maturation schedule. To go beyond these generic insights, "Evolutionary Impact Assessments" (EvoIAs) are proposed to quantify the effects of management measures, through the evolutionary response of specific stocks, on the utility functions defined by managers. The Study Group on Fisheries Induced Adaptive Change [SGFIAC] proposes to further develop this framework in dialogue with fisheries scientists and managers, with the aim of integrating the effects of fisheries-induced evolution into fisheries management advice. Developing EvoIAs in the context of suitable case studies is considered to be the most efficient way for making progress

A UV LED-based fast-pulsed photoelectron source for time-of-flight studies

We report on spectroscopy and time-of-flight measurements using an 18 keV fast-pulsed photoelectron source of adjustable intensity, ranging from single photoelectrons per pulse to 5 photoelectrons per microsecond at pulse repetition rates of up to 10 kHz. Short pulses between 40 ns and 40 microseconds in length were produced by switching light emitting diodes with central output wavelengths of 265 nm and 257 nm, in the deep ultraviolet (or UV-C) regime, at kHz frequencies. Such photoelectron sources can be useful calibration devices for testing the properties of high-resolution electrostatic spectrometers, like the ones used in current neutrino mass searches.Comment: 16 pages, 11 figure