Terapia combinata laser CO2 e PDT nei basaliomi nodulari ed infiltranti

Il basalioma è la forma di tumore cutaneo maligno più comune nella razza caucasica; esistono numerose soluzioni terapeutiche per il suo trattamento. Scopo del nostro studio è stato quello di trattare basaliomi nodulari ed infiltranti utilizzando la combinazione di laser CO2 e successiva terapia fotodinamica sulle stesse lesioni. Sono state trattate 4 lesioni su altrettanti pazienti: 2 presentavano basaliomi infiltranti e 2 basaliomi nodulari. Il periodo medio di follow-up è stato di 8 mesi. Le lesioni trattate sono state fotografate e sottoposte a valutazione con videodermoscopia e microscopio laser confocale prima e dopo i trattamenti, ad intervalli di tempo standardizzati. Tutte le lesioni hanno mostrato un’eccellente risposta terapeutica e nessuna complicanza significativa è stata riscontrata. L’utilizzo sequenziale di laser CO2 e terapia fotodinamica, nel trattamento dei basaliomi infiltranti e nodulari, ha determinato una guarigione completa degli stessi, dimostrandosi un’eccellente opzione terapeutica con ottimi outcome estetici. Tali procedure permettono di evitare interventi invasivi su sedi esteticamente rilevanti, in pazienti con lesioni multiple o recidivanti ed affetti da comorbidità severe e in terapia con anticoagulanti

Multiphoton Laser Microscopy and Fluorescence Lifetime Imaging for the Evaluation of the Skin

Multiphoton laser microscopy is a new, non-invasive technique providing access to the skin at a cellular and subcellular level, which is based both on autofluorescence and fluorescence lifetime imaging. Whereas the former considers fluorescence intensity emitted by epidermal and dermal fluorophores and by the extra-cellular matrix, fluorescence lifetime imaging (FLIM), is generated by the fluorescence decay rate. This innovative technique can be applied to the study of living skin, cell cultures and ex vivo samples. Although still limited to the clinical research field, the development of multiphoton laser microscopy is thought to become suitable for a practical application in the next few years: in this paper, we performed an accurate review of the studies published so far, considering the possible fields of application of this imaging method and providing high quality images acquired in the Department of Dermatology of the University of Modena

Multiphoton Laser Microscopy with Fluorescence Lifetime Imaging and Skin Cancer

Multiphoton Laser Microscopy with Fluorescence Lifetime Imaging and Skin Cance

Terapia combinata laser CO2 e PDT nei basaliomi nodulari ed infiltranti

Il basalioma è la forma di tumore cutaneo maligno più comune nella razza caucasica; esistono numerose soluzioni terapeutiche per il suo trattamento. Scopo del nostro studio è stato quello di trattare basaliomi nodulari ed infiltranti utilizzando la combinazione di laser CO2 e successiva terapia fotodinamica sulle stesse lesioni. Sono state trattate 4 lesioni su altrettanti pazienti: 2 presentavano basaliomi infiltranti e 2 basaliomi nodulari. Il periodo medio di follow-up è stato di 8 mesi. Le lesioni trattate sono state fotografate e sottoposte a valutazione con videodermoscopia e microscopio laser confocale prima e dopo i trattamenti, ad intervalli di tempo standardizzati. Tutte le lesioni hanno mostrato un’eccellente risposta terapeutica e nessuna complicanza significativa è stata riscontrata. L’utilizzo sequenziale di laser CO2 e terapia fotodinamica, nel trattamento dei basaliomi infiltranti e nodulari, ha determinato una guarigione completa degli stessi, dimostrandosi un’eccellente opzione terapeutica con ottimi outcome estetici. Tali procedure permettono di evitare interventi invasivi su sedi esteticamente rilevanti, in pazienti con lesioni multiple o recidivanti ed affetti da comorbidità severe e in terapia con anticoagulanti

Combined carbon dioxide laser with photodynamic therapy for the treatment of nodular and infiltrative basal cell carcinoma

[No abstract available

Dermoscopic yellow structures in basal cell carcinoma

BACKGROUND: Yellowish structures in dermoscopy comprise milia-like cysts (MLCs) and yellow lobular-like structures. OBJECTIVE: This study aimed at establishing the frequency of these features in BCC and at describing their dermoscopic details. METHODS: A retrospective analysis of digital dermoscopic images referring to 400 BCCs was performed. Images were evaluated for the presence of starry and cloudy MLCs and yellow lobular-like structures. RESULTS: Among the 400 BCCs constituting our database, 40 presented yellowish structures (10%). "Yellow" BCCs were located more frequently on the head and were mainly of the nodular type. MLCs were observed in 7.75% of the cases (with a mean number of 4.9 MLCs per lesion), whereas yellow globules were noticed in 4.2% /ucodep of the lesions. CONCLUSION: In the presence of BCC specific dermoscopic criteria, the observation of MLCs and yellow lobular-like structures should not prompt the dermatologist to exclude the diagnosis of BC

Long-term efficacy of high doses of intravenous immunoglobulins in generalized scleromyxoedema: Case report

Scleromyxoedema is a rare disease with a progressive and disabling course involving dermal deposition of mucin and fibroblast proliferation; it is characterized clinically by a diffuse papular eruption, skin thickening, oedema and decreased skin flexibility, especially of the face and hands. Current therapy options are based on evidence from a limited number of case reports. The clinical manifestations and treatment of a 64-year-old man affected by scleromyxoedema with severe skin involvement of the face, arms and hands, decreased mouth opening and hypomotility of the fingers are reported. Dysphagia, asthenia and immunoglobulin G lambda monoclonal gammopathy were also present. Previous treatment with topical and systemic corticosteroids, psoralen plus ultraviolet A radiation therapy, plasmapheresis, extracorporeal photochemotherapy, hydroxychloroquine and cyclophosphamide had been unsuccessful. Treatment with intravenous immunoglobulins at a dosage of 2 g/kg monthly was started. Considerable improvements were observed after seven cycles of therapy, with recovery of skin elasticity, an increase in facial mimic movement, restoration of joint function and improvement in the modified Rodnan score. There were no observed side-effects. The patient remains in remission on monthly maintenance intravenous immunoglobulins, 2 years after initial treatment