Numerical error evaluation for tip clearance flow calculations in a centrifugal compressor

Since globally mesh independent solution are still beyond available computer resources for industrial cases, a method to quantify locally the numerical error is proposed. The design of experiments method helps selecting mesh parameters that influence the tip clearance solution, so that additional meshes are computed to evaluate the numerical error on the shroud friction coefficient. In the field of CFD applied to turbomachinery, this study results from a partnership between ENSICA, Liebherr-Aerospace Toulouse and Numeca International. This paper focuses on numerical error evaluation for RANS simulations, applied to centrifugal compressor flow field calculations. CFD is now commonly used for centrifugal compressor design optimization, but, as Hutton and Casey develop in [1], there is an urging demand for improved quality and trust in industrial CFD. Indeed, this stresses the need for comprehensive and thorough numerical error evaluation, namely the process of verification, as defined for example by Oberkampf and Trucano in [2]. Unfortunately, 3D turbulent calculations for turbomachinery components are still very demanding in computational resources and, to the knowledge of the author, there is no published result concerning comprehensive verification of the entire flow field in centrifugal compressors. As a first step on the way to achieve that, this paper presents a method aiming at the obtention of a numerical solution that can be regarded as locally mesh-independent. In other words, the objective is to compute the flow field on a grid such that the solution obtained has a specific region where the numerical error is negligible. It has long been recognized that the tip clearance of a centrifugal compressor is of paramount importance for aerodynamic performances, which means that accurately predicting the flow field in this region is crucial for accurate prediction of performances by means of CFD codes. Numerous studies have been published that compare numerical and experimental results in the tip region. However, in these studies, numerical error still remains an issue; for instance Basson and Lakshminarayana [3] show excellent comparisons with experiments, but they attribute the remaining discrepancies to insufficient grid resolution. Indeed, accurate predictions of global effects, such as efficiency, require a fine description of flow details. Therefore, friction at the shroud endwall is the concern of the study, since it is a very sensitive indicator of the quality of the velocity profile’s prediction at the wall

Appui bibliographique d'une enquête épidémiologique sur les facteurs influençant les performances de reproduction de la vache laitière en région Rhône-Alpes

LYON1-BU Santé (693882101) / SudocTOULOUSE-EN Vétérinaire (315552301) / SudocSudocFranceF

Modélisation du fonctionnement primaire et de la croissance de la forêt de pin maritime

National audienc

Modélisation du fonctionnement primaire et de la croissance de la forêt de pin maritime

National audienc

Mesh-generation parameters influence on centrifugal compressor simulation for design optimisation

As advocated by Denton [AGARD LS-195, (1994)], three-dimensional CFD calculations are more and more used in the process of designing centrifugal compressors. Therefore, numerical accuracy is an issue if valuable design decisions are to be based on CFD results. This paper aims at correlating mesh-parameters and calculated flow quantities. The design-of-experiment method (DOE) is used to identify which mesh-parameters influence any given flow quantity. The emphasis is put on global performances (mass-flow rate, pressure-ratio and efficiency), and on local features (friction coefficients and local velocity-profiles). The outcome of the study is the connection between mesh-parameters and specific flowproperties. This can be further used to derive numerical benchmarks, such as reported by Dufour et al. [XXI ICTAM conference, Poland (2004)] for the tip-clearance flow

Obstetrical and postpartum complications in women with hereditary fibrinogen disorders: a systematic literature review

Hereditary fibrinogen disorders (HFD) are rare quantitative or qualitative fibrinogen anomalies, including afibrinogenaemia (A), hypofibrinogenaemia (H), dysfibrinogenaemia (D) and hypodysfibrinogenaemia (HD). As fibrinogen plays an essential role in pregnancy, we addressed the issue of obstetrical and postpartum complications in women with HFD

Coexpression of factor VIII and factor von Willebrand variants in a woman with heavy menstrual bleeding

Heavy menstrual bleeding is one of the most common causes of consultation in haematology. We present the clinical case of a 20-year-old woman referred by her gynaecologist due to heavy menstrual bleeding since menarche, complicated by iron deficiency anaemia. Haemostasis work-up was initially suggestive of a von Willebrand disease type 1. Genetic analyses by whole exome sequencing lead to a fortuitous discovery of haemophilia by identifying a heterozygous missense mutation in F8, exon 8 c.1127T>G:p.Val376Gly, previously reported in a patient with mild haemophilia A. The bleeding phenotype worsened by concomitant low von Willebrand factor (VWF) due to VWF variants influencing VWF levels. Our case highlights how whole exome sequencing can help to correct an erroneous diagnosis and identify polymorphisms that eventually contribute to the overall haemostatic balance

Haematologic data, iron parameters and molecular findings in two new cases of iron-refractory iron deficiency anaemia

Matriptase-2 (Tmprss6), a type II transmembrane serine protease, has an essential role in iron homoeostasis as a hepcidin regulator. Recently, patients with TMPRSS6 mutations and suffering from iron-refractory iron deficiency anaemia (IRIDA) have been reported. We describe two new cases of IRIDA, one patient of Swiss origin and the second of Italian origin. The first case results from a large deletion of 1054 nucleotides corresponding to an in frame deletion of 30 amino acid residues in the low-density lipoprotein receptor-1/-2 (LDLR-1/-2) domains and from a missense mutation in CUB1 (S304L). In the second case, a homozygous G-->C mutation in the last nucleotide of exon 15 and which modified the consensus sequence of the 5' splice donor site of intron 15 (AGgt-->ACgt) was identified. Both patients had a high hepcidin level and low serum iron and transferrin saturation compared to age-matched controls. Continuous perfusion of i.v. iron 4 h/d x 5 d in the first case resulted in a significant rise in haemoglobin. These new cases of IRIDA illustrate the importance of LDLR-1/-2 and CUB1 domains in matriptase-2 function as well as the role of matriptase-2 in hepcidin regulation. Furthermore a deletional form of TMPRSS6 (in LDLR-1/-2 domains) resulting in IRIDA is described for the first time. These cases reinforce the belief that patients suffering from IRIDA have no specific geographical or ethnic distribution and are sporadic secondary to different mutations of the matriptase-2 gene

Simultaneous enzyme grafting on bio-inspired scaffolds for antibacterial protection

International audienceSurface bacterial contamination represents a crucial health and industrial concern which requires new strategies to be continuously developed

Methods to investigate miRNA function: focus on platelet reactivity

MicroRNAs (miRNAs) are small noncoding RNAs modulating protein production. They are key players in regulation of cell function and are considered as biomarkers in several diseases. The identification of the proteins they regulate, and their impact on cell physiology, may delineate their role as diagnostic or prognostic markers and identify new therapeutic strategies. During the last 3 decades, development of a large panel of techniques has given rise to multiple models dedicated to the study of miRNAs. Since plasma samples are easily accessible, circulating miRNAs can be studied in clinical trials. To quantify miRNAs in numerous plasma samples, the choice of extraction and purification techniques, as well as normalization procedures, are important for comparisons of miRNA levels in populations and over time. Recent advances in bioinformatics provide tools to identify putative miRNAs targets that can then be validated with dedicated assays. In vitro and in vivo approaches aim to functionally validate candidate miRNAs from correlations and to understand their impact on cellular processes. This review describes the advantages and pitfalls of the available techniques for translational research to study miRNAs with a focus on their role in regulating platelet reactivity