Stochastic conjugate gradient based multi-user constant modulus algorithm for use in multiuser DS-CDMA environment

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Adaptive step-size blind multi-user detectors for DS-CDMA systems under deterministically and Markovian time-varying multipath environments

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Short- versus Long-term Dual Anti-platelet Therapy (DAPT) in Secondary Prevention for Ischaemic Stroke – A Network Metanalysis

Aim: This review aimed to compare the efficacy and safety of short-term (==1 year) dual-antiplatelet therapy (DAPT) in secondary prevention for ischaemic stroke. Methods and results: We searched MEDLINE, EMBASE (Ovid), PubMed, Cochrane Library, ClinicalTrials.gov and Google Advanced Search for randomised controlled trials. The population consisted of patients with recent ischaemic stroke or transient ischaemic attack. The intervention was DAPT with a combination of aspirin, clopidogrel and dipyridamole compared to either aspirin or clopidogrel in monotherapy. The primary outcome was the rate of all recurrent stroke (ischaemic and haemorrhagic). Secondary outcomes were ischaemic stroke, all bleeding, severe bleeding, all-cause death, cardiovascular death and myocardial infarction. Data were pooled by network metanalysis and pairwise metanalyses. Sixteen studies with 55,261 participants were included. Compared to aspirin, DAPT with aspirin clopidogrel decreased the risk of recurrent stroke (short-term OR 0.67, 95%CI 0.58-0.77; long-term OR 0.84, 95%CI 0.70- 1.01) at the expense of increased risk of bleeding (short-term OR 1.76, 95%CI 1.26-2.46; long-term OR 2.25, 95%CI 1.97-2.57). DAPT with aspirin clopidogrel and clopidogrel in monotherapy had similar long-term risk of recurrent stroke (OR 0.98, 95%CI 0.83-1.14), but DAPT was associated with increased risk of bleeding (OR 2.77, 95%CI 2.21-3.46). Network metanalysis showed that short-term aspirin clopidogrel DAPT had the best risk-benefit profile, followed by long-term aspirin clopidogrel DAPT and clopidogrel alone. Aspirin dipyridamole DAPT was less effective. Conclusion: Short-term DAPT had better risk-benefit profile than long-term DAPT.European Society of Cardiology (ESC)NIH

Associations between message features and subjective evaluations of the sensation value of antidrug public service announcements.

In 1998, the U.S. Congress stepped up the nation's focus on drug and alcohol abuse by allocating $1 billion to the Office of National Drug Control Policy for mass media-based prevention campaigns and evaluations. We now know some of the key elements of effective media-based antidrug campaigns, including effec

NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network.

Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. Here, we show deletion of NKX2-5, a critical component of the cardiac gene regulatory network, in human embryonic stem cells (hESCs), results in impaired cardiomyogenesis, failure to activate VCAM1 and to downregulate the progenitor marker PDGFRα. Furthermore, NKX2-5 null cardiomyocytes have abnormal physiology, with asynchronous contractions and altered action potentials. Molecular profiling and genetic rescue experiments demonstrate that the bHLH protein HEY2 is a key mediator of NKX2-5 function during human cardiomyogenesis. These findings identify HEY2 as a novel component of the NKX2-5 cardiac transcriptional network, providing tangible evidence that hESC models can decipher the complex pathways that regulate early stage human heart development. These data provide a human context for the evaluation of pathogenic mutations in congenital heart disease.Nat Commun 2018 Apr 10; 9(1):1373

A mysterious cause of constrictive pericarditis: unfolding of the missing link

10.1093/ehjci/jex339European heart journal cardiovascular Imaging19447

Fast convergent multiuser constant modulus algorithm for use in multiuser DS-CDMA environment

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