Structure of social relations in the novel \emph{The Master and Margarita} by M. A. Bulgakov: A network analysis of verbal communications

A network analysis of the structure of social relationships in one of the most popular Russian novels of the Soviet era The Master and Margarita by M. Bulgakov has been carried out. The structure of the novel is complex (`a story within a story'); the real-world- and the other-world-characters are interacting. A complex and unusual structure of the character network is expected. Presumably, the network may be split in two subgraphs owing very different properties. This complex and unusual composition makes the novel especially attractive for a network analysis. In our study, only paired verbal communications between explicitly present and acting characters have been taken into account. Based on a character pair verbal communication matrix, a graph has been constructed, the vertices of which are the characters of the novel, while the edges correspond to the connections between them. Taking only dialog into account leads to the result, that the character network can be described by an ordinary, rather than a directed graph. Since the activity of the dialogs was out of our scope, the edges have been given no weights. The largest connected component of the graph consists of 76 characters. Centralities were computed to characterize the network. The assortativity coefficient of the network under consideration is negative -0.133, i.e., the network does not demonstrate the properties of a social network. The structure of the communities in the network was also analysed. In addition to the obvious large communities - the characters from the Yershalaim part of the novel and the characters of the Moscow part - the analysis also revealed a fine structure in the Moscow component. Using the analysis of centralities, a group of main characters has been detected. The central characters of the novel are Bezdomny, Woland, Levi Matthew, Koroviev, Azazello, Behemoth, Bosoi, Warenukha, Master, and Margarita.Comment: 21 pages, 2 figures, 4 tables, 39 reference

Модификации заглавий в автопереводе (на материале сборника В. Набокова «Возвращение Чорба»)

The article is devoted to study of the self-translation of stories' titles by Vladimir Nabokov from the point of view of structural and semantic changes, stipulated by use of semantic reduction, semantic specification, compensation and modulation. The authors study the literary text on the grounds of compare-and-contrast, structural, intertextual and cognitive methods of research. The main subject of research are the stories from the collection "The return of Chorb". The bilingual writer often deviates in translation from a proclaimed principle of "literal translation" what is stipulated by Nabokov’s desire to specify or to emphasize the semantics of the title. The article also explains the reasons why certain stories have not been translated by the author into English.Статья посвящена изучению автоперевода заглавий рассказов Владимира Набокова с точки зрения структурных и семантических модификаций, обусловленных использованием приемов семантической редукции, смысловой конкретизации, компенсации, модуляции. Авторы работы обращаются к сравнительно-сопоставительному, структурному, интертекстуальному и когнитивному методам исследования художественного текста. Основным материалом исследования стали рассказы из сборника «Возвращение Чорба», при переводе которых писатель-билингв часто отклоняется от манифестированного принципа «буквальности», что обусловлено стремлением В. Набокова конкретизировать или акцентировать семантику заглавий. В статье также объясняются причины, по которым некоторые рассказы не были переведены автором на английский язык

Agriculture, Forestry and Other Land Use (AFOLU)

Agriculture, Forestry, and Other Land Use (AFOLU) is unique among the sectors considered in this volume, since the mitigation potential is derived from both an enhancement of removals of greenhouse gases (GHG), as well as reduction of emissions through management of land and livestock (robust evidence; high agreement). The land provides food that feeds the Earth’s human population of ca. 7 billion, fibre for a variety of purposes, livelihoods for billions of people worldwide, and is a critical resource for sustainable development in many regions. Agriculture is frequently central to the livelihoods of many social groups, especially in developing countries where it often accounts for a significant share of production. In addition to food and fibre, the land provides a multitude of ecosystem services; climate change mitigation is just one of many that are vital to human well-being (robust evidence; high agreement). Mitigation options in the AFOLU sector, therefore, need to be assessed, as far as possible, for their potential impact on all other services provided by land. [Section 11.1

The Study of Possible Soybean Introduction into New Cultivation Regions Based on the Climate Change Analysis and the Agro-Ecological Testing of the Varieties

Analyzing agro-climatic conditions for the period of 1981–2020 has revealed a tendency for local climate warming under the condition of its aridization in the territory of the Central region of the Russian Non-Chernozem zone, and the new northern borders for soybean growing in the region have been marked. The isotherm of the sum of active temperatures has been established to have shifted towards high latitudes by 150–200 km. The values of the sum of active temperatures have increased from 1700–2200 °C to 1950–2400 °C, while the amount of precipitation during the growing season has decreased by 20–40 mm on average, from 270–280 mm to 190–230 mm. Three agro-climatic subzones—northern (NAS), central (CAS) and southern (SAS)—have been identified, each characterized by similar temperature and humidity conditions during the growing season. Thus, in the northern agro-climatic subzone, the sum of temperatures during the growing season is 2000–2200 °C, the HTC (hydrothermal coefficient) is 1.4–1.7, and the sum of precipitation is 285–295 mm; in the central subzone, the sum of temperatures is 2200–2400 °C, the HTC is 1.1–1.4, and the sum of precipitation is 265–285 mm; in the southern one, the sum of temperatures is 2400–2600 °C, the HTC is 0.7–1.1, and the sum of precipitation is 255–265 mm. Along with the northern ecotype varieties recommended for this zone, the vegetation features of early maturing soybean varieties of other ecological types—southern and Far Eastern—were studied. As a result of the agro-ecological analysis of early maturing soybean varieties, it has been found that the soybeans belonging to the group of very early or early maturing with a determinant type of growth are recommended for cultivation in the northern agro-climatic subzone of the Central region of the Non-Chernozem zone; the soybean varieties belonging to the group of very early or early maturing with a determinant or semi-determinant type of growth—in the central zone; the soybean varieties belonging to the group of very early or early maturing with a determinant, semi-determinant, and indeterminant type of growth—in the southern zone. Considering the variety characteristics and the agro-ecological tests conducted, it has been found that the northern ecotype varieties can sustainably ripen in all agro-climatic subzones in the Central region of the Non-Chernozem zone, the southern and the Far Eastern varieties—in the central and the southern zones

Enhancement of the Local CD8⁺ T-Cellular Immune Response to <i>Mycobacterium tuberculosis</i> in BCG-Primed Mice after Intranasal Administration of Influenza Vector Vaccine Carrying TB10.4 and HspX Antigens

BCG is the only licensed vaccine against Mycobacterium tuberculosis (M.tb) infection. Due to its intramuscular administration route, BCG is unable to induce a local protective immune response in the respiratory system. Moreover, BCG has a diminished ability to induce long-lived memory T-cells which are indispensable for antituberculosis protection. Recently we described the protective efficacy of new mucosal TB vaccine candidate based on recombinant attenuated influenza vector (Flu/THSP) co-expressing TB10.4 and HspX proteins of M.tb within an NS1 influenza protein open reading frame. In the present work, the innate and adaptive immune response to immunization with the Flu/THSP and the immunological properties of vaccine candidate in the BCG-prime → Flu/THSP vector boost vaccination scheme are studied in mice. It was shown that the mucosal administration of Flu/THSP induces the incoming of interstitial macrophages in the lung tissue and stimulates the expression of co-stimulatory CD86 and CD83 molecules on antigen-presenting cells. The T-cellular immune response to Flu/THSP vector was mediated predominantly by the IFNγ-producing CD8+ lymphocytes. BCG-prime → Flu/THSP vector boost immunization scheme was shown to protect mice from severe lung injury caused by M.tb infection due to the enhanced T-cellular immune response, mediated by antigen-specific effector and central memory CD4+ and CD8+ T-lymphocytes

Mucosal Influenza Vector Vaccine Carrying TB10.4 and HspX Antigens Provides Protection against Mycobacterium tuberculosis in Mice and Guinea Pigs

New strategies providing protection against tuberculosis (TB) are still pending. The airborne nature of Mycobacterium tuberculosis (M.tb) infection assumes that the mucosal delivery of the TB vaccine could be a more promising strategy than the systemic route of immunization. We developed a mucosal TB vaccine candidate based on recombinant attenuated influenza vector (Flu/THSP) co-expressing truncated NS1 protein NS1(1–124) and a full-length TB10.4 and HspX proteins of M.tb within an NS1 protein open reading frame. The Flu/THSP vector was safe and stimulated a systemic TB-specific CD4+ and CD8+ T-cell immune response after intranasal immunization in mice. Double intranasal immunization with the Flu/THSP vector induced protection against two virulent M.tb strains equal to the effect of BCG subcutaneous injection in mice. In a guinea pig TB model, one intranasal immunization with Flu/THSP improved protection against M.tb when tested as a vaccine candidate for boosting BCG-primed immunity. Importantly, enhanced protection provided by a heterologous BCG-prime → Flu/THSP vector boost immunization scheme was associated with a significantly reduced lung and spleen bacterial burden (mean decrease of 0.77 lg CFU and 0.72 lg CFU, respectively) and improved lung pathology 8.5 weeks post-infection with virulent M.tb strain H37Rv

Design and Immunological Properties of the Novel Subunit Virus-like Vaccine against SARS-CoV-2

The COVID-19 pandemic is ongoing, and the need for safe and effective vaccines to prevent infection and to control spread of the virus remains urgent. Here, we report the development of a SARS-CoV-2 subunit vaccine candidate (Betuvax-CoV-2) based on RBD and SD1 domains of the spike (S) protein fused to a human IgG1 Fc fragment. The antigen is adsorbed on betulin adjuvant, forming spherical particles with a size of 100–180 nm, mimicking the size of viral particles. Here we confirm the potent immunostimulatory activity of betulin adjuvant, and demonstrate that two immunizations of mice with Betuvax-CoV-2 elicited high titers of RBD-specific antibodies. The candidate vaccine was also effective in stimulating a neutralizing antibody response and T cell immunity. The results indicate that Betuvax-CoV-2 has good potential for further development as an effective vaccine against SARS-CoV-2

Russian forest sequesters substantially more carbon than previously reported

Abstract Since the collapse of the Soviet Union and transition to a new forest inventory system, Russia has reported almost no change in growing stock (+ 1.8%) and biomass (+ 0.6%). Yet remote sensing products indicate increased vegetation productivity, tree cover and above-ground biomass. Here, we challenge these statistics with a combination of recent National Forest Inventory and remote sensing data to provide an alternative estimate of the growing stock of Russian forests and to assess the relative changes in post-Soviet Russia. Our estimate for the year 2014 is 111 ± 1.3 × 109 m3, or 39% higher than the value in the State Forest Register. Using the last Soviet Union report as a reference, Russian forests have accumulated 1163 × 106 m3 yr-1 of growing stock between 1988–2014, which balances the net forest stock losses in tropical countries. Our estimate of the growing stock of managed forests is 94.2 × 109 m3, which corresponds to sequestration of 354 Tg C yr-1 in live biomass over 1988–2014, or 47% higher than reported in the National Greenhouse Gases Inventory

SARS-CoV-2 Subunit Virus-like Vaccine Demonstrates High Safety Profile and Protective Efficacy: Preclinical Study

Public health threat coming from a rapidly developing COVID-19 pandemic calls for developing safe and effective vaccines with innovative designs. This paper presents preclinical trial results of “Betuvax-CoV-2”, a vaccine developed as a subunit vaccine containing a recombinant RBD-Fc fusion protein and betulin-based spherical virus-like nanoparticles as an adjuvant (“Betuspheres”). The study aimed to demonstrate vaccine safety in mice, rats, and Chinchilla rabbits through acute, subchronic, and reproductive toxicity studies. Along with safety, the vaccine demonstrated protective efficacy through SARS-CoV-2-neutralizing antibody production in mice, rats, hamsters, rabbits, and primates (rhesus macaque), and lung damage and infection protection in hamsters and rhesus macaque model. Eventually, “Betuvax-CoV-2” was proved to confer superior efficacy and protection against the SARS-CoV-2 in preclinical studies. Based on the above results, the vaccine was enabled to enter clinical trials that are currently underway