Niraparib in patients with metastatic castration-resistant prostate cancer and DNA repair gene defects (GALAHAD): a multicentre, open-label, phase 2 trial

Background Metastatic castration-resistant prostate cancers are enriched for DNA repair gene defects (DRDs) that can be susceptible to synthetic lethality through inhibition of PARP proteins. We evaluated the anti-tumour activity and safety of the PARP inhibitor niraparib in patients with metastatic castration-resistant prostate cancers and DRDs who progressed on previous treatment with an androgen signalling inhibitor and a taxane. Methods In this multicentre, open-label, single-arm, phase 2 study, patients aged at least 18 years with histologically confirmed metastatic castration-resistant prostate cancer (mixed histology accepted, with the exception of the small cell pure phenotype) and DRDs (assessed in blood, tumour tissue, or saliva), with progression on a previous next-generation androgen signalling inhibitor and a taxane per Response Evaluation Criteria in Solid Tumors 1.1 or Prostate Cancer Working Group 3 criteria and an Eastern Cooperative Oncology Group performance status of 0–2, were eligible. Enrolled patients received niraparib 300 mg orally once daily until treatment discontinuation, death, or study termination. For the final study analysis, all patients who received at least one dose of study drug were included in the safety analysis population; patients with germline pathogenic or somatic biallelic pathogenic alterations in BRCA1 or BRCA2 (BRCA cohort) or biallelic alterations in other prespecified DRDs (non-BRCA cohort) were included in the efficacy analysis population. The primary endpoint was objective response rate in patients with BRCA alterations and measurable disease (measurable BRCA cohort). This study is registered with ClinicalTrials.gov, NCT02854436. Findings Between Sept 28, 2016, and June 26, 2020, 289 patients were enrolled, of whom 182 (63%) had received three or more systemic therapies for prostate cancer. 223 (77%) of 289 patients were included in the overall efficacy analysis population, which included BRCA (n=142) and non-BRCA (n=81) cohorts. At final analysis, with a median follow-up of 10·0 months (IQR 6·6–13·3), the objective response rate in the measurable BRCA cohort (n=76) was 34·2% (95% CI 23·7–46·0). In the safety analysis population, the most common treatment-emergent adverse events of any grade were nausea (169 [58%] of 289), anaemia (156 [54%]), and vomiting (111 [38%]); the most common grade 3 or worse events were haematological (anaemia in 95 [33%] of 289; thrombocytopenia in 47 [16%]; and neutropenia in 28 [10%]). Of 134 (46%) of 289 patients with at least one serious treatment-emergent adverse event, the most common were also haematological (thrombocytopenia in 17 [6%] and anaemia in 13 [4%]). Two adverse events with fatal outcome (one patient with urosepsis in the BRCA cohort and one patient with sepsis in the non-BRCA cohort) were deemed possibly related to niraparib treatment. Interpretation Niraparib is tolerable and shows anti-tumour activity in heavily pretreated patients with metastatic castration-resistant prostate cancer and DRDs, particularly in those with BRCA alterations

Venezuela: ¿un laboratorio de experimentación en política económica?

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Revista Mexicana de Agronegocios [Reseña de revista]

Review of Revista Mexicana de Agronegocios, Year XXV, Vol. 48, January-June 2021, official publication of the Sociedad Mexicana de Administración Agropecuaria (SOMEXAA) [Mexican Society for Agricultural Management]

Sistemas alimentarios urbanos y su gobernanza, ¿una alternativa viable para Venezuela en el marco de los sistemas agroalimentarios sostenibles?

In recent decades, there has been growing concern in the literature about the challenge of feeding sustainably, a continuously growing population. There is also a growing consensus that agri-food systems, in addition to ensuring food security, should adopt more efficient and sustainable production methods, be more sustainable and inclusive, and adapt to climate change. This is even more important for cities, which concentrate the largest proportion of the population and consume more than 2/3 of the total water and energy. In this scenario, based on secondary sources, an exploratory and review study was developed. It aimed to study an alternative that has recently emerged at the international level: urban food systems and their governance, based on a review of some theoretical elements and trends. Based on this review, the paper discussed its viability in the Venezuelan case, by examining some recent Venezuelan experiences and considering both the available resources and the major barriers to its materialization at the national level. It also discussed how they could contribute to the achievement of the United Nations Sustainable Development Goals, in particular, as spaces capable of providing healthy food, sustainably and that allow improving the livelihoods of the population. Among the primary resources available, the country's education and training infrastructure in the area was identified, together with a renewed legal and institutional framework that is – on paper – openly pro-environmentalist and citizen-oriented. Among the limitations were: i) increasing deforestation and burning of plant species; ii) deterioration of the drinking water service and its use in urban agriculture; iii) migration of the population, particularly those with higher academic and professional training; iv) deterioration of the National Science, Technology, and Innovation System and decline of public financing through the LOCTI; v) opacity and untimeliness of official information; and vi) scarcity of financing for installation and adaptation of new or existing developments. Another aspect addressed was the difficulties in implementing an adequate governance model, due in part to the growing centralization of government decisions, loss of authority of local governments, and limited dialogue and negotiation between the different levels of government, the private sector, and the communities

Agrifood Research Center (CIAAL): Balance of a decade.

1.- ArtículosLa concentración de las queserías rurales de Cajamarca: Retos y dificultades de una estrategia colectiva de activación.The concentration of rural cheese factories of Cajamarca: Challenges and difficulties of a collective strategy of activation.La concentration des fromageries rurales de Cajamarca: Enjeux et difficultés d'une stratégie collective d'activation liée à la qualité.Boucher, François; Requier-Desjardins, DenisTradition versus modernisme dans la viticulture du brésil.Tradición versus modernismo en la vitivinicultura brasileña.Tradition versus modernism in the Brazilian wine industry.Desplobins, GérardLa rentabilidad económica de la industria agroalimentaria en el mercado del aceite de oliva. El caso de Andalucía.Economic profitability in the olive oil market. The case of Andalucía.La rentabilité économique de l'industrie agroalimentaire sur le marché de l'huile d'olive. Le cas de l'andalousie.García Brenes, DavidReformas de mercado, instituciones y costos de transacción: Impacto de las reformas en los pequeños productores Andinos de papa en Venezuela.Market reforms, institutions and transaction cost: Impact of the reforms on small Andean potato producers in Venezuela.Les réformes du marché, les institutions et les coûts de transaction: Impacts des réformes sur les petits producteurs des Andes au Venezuela.Llambí, Luis; Duarte, MagdaPromoción de inversiones agrícolas privadas en el estado Falcón, Venezuela.Promotion of private agricultural investments at Falcon state, Venezuela.Promotion des investissements agricoles privés dans l'état de Falcon, Venezuela.Piña Zambrano, HenriLa educación y la capacitación rural en la región Andina.Education and rural training at the Andean region.L'éducation et la capacitation rurale dans les pays s de la communauté andine.Quevedo, Rafael IsidroConducta del consumidor de carne bovina según clase socioeconómica en el municipio Maracaibo, estado Zulia, Venezuela.Beef consumer behavior according to socioeconomic status at the municipio Maracaibo, Zulia state, Venezuela.La conduite du consommateur de viande de boeuf à la municipalité de Maracaibo, état de Zulia, Venezuela.Segovia, Emma; Contreras, Diego; Marcano, Daniel; Pirela, Ramón; Albornoz, Arlenis2.- ReseñasCentro de Investigaciones Agroalimentarias (CIAAL): Balance de una década.Agrifood Research Center (CIAAL): Balance of a decade.Centre de recherches agroalimentaires: bilan d'une décennie.Reseñado por: Anido, DanielExposición itinerante "de alimentos, marcas y registros. Venezuela, 1877-1929".Mobile exhibition "foods, brands and registers. Venezuela, 1877-1929".Exposition itinérante "d'aliments, marques et registres: Venezuela 1877-1929".Índice [email protected] analíticosemestra

El consumo alimentario y disponibilidades de energía y nutrientes en Venezuela, 1980-2011: principales cambios e implicaciones nutricionales

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Revista Mexicana de Agronegocios [Reseña de revista]

Review of the Mexican Agribusiness Journal, Year XXVI, Vol. 50, January-June 2022, published by the (Sociedad Mexicana de Administración Agropecuaria-SOMEXAA), Mexic

Revista Economía Agraria y Recursos Naturales (EARN) [Reseña de revista]

Review of Agrarian Economy and Natural Resources Journal (Revista Economía Agraria y Recursos Naturales, EARN) Vol. 20, No. 1 (2020), a publication of the Spanish Agricultural Economics Association (AEEA) and the Universitat Politècnica València (UPV, Spain)

Información Investigador: Anido Rivas, José Daniel

Doctorado4045III - 2009; I - 2006; I - 2005; I - 2004; I - 2003; I - 200288 - 2005; 83 - 2003; 45 - 2001Consumo de alimentos, Modelos de consumo, Análisis microeconómico del consumo, Políticas económicas y sectoriales en la agricultura y la alimentación. Estadísticas de consumo alimentario (disponibilidades alimentarias y nutricionales). Seguridad alimentaria, Economía del ambiente y desarrollo agrícola.Mayo de 2016Economista y Contador Público+58 274 2401031; 2403855Facultad de Ciencias Económicas y [email protected]; [email protected]; [email protected]; [email protected]. Núcleo La Liria, edificio G Leocadio Hontoria, 2º piso, CIAA

Una Aproximación a la Explicación del Fenómeno Inflacionario Venezolano a partir de los Ajustes Ortodoxos, y sus Relaciones con la Inversión Durante las Últimas dos Décadas

Una Aproximación a la Explicación del Fenómeno Inflacionario Venezolano a partir de los Ajustes Ortodoxos, y sus Relaciones con la Inversión Durante las Últimas dos Décadas (Anido, Daniel)INTRODUCCIÓNCAPÍTULO I. EL PROBLEMA EN ESTUDIOMarco TeóricoRevisión de la LiteraturaCAPÍTULO II. METODOLOGÍAA. Metodología general de la investigaciónB. Modelos empleadosCAPÍTULO III. DATOS Y FUENTES DE INFORMACIÓNDatos y Definición de variablesTabla de datosCAPÍTULO IV. ANÁLISIS Y RESULTADOSA. Selección del Modelo óptimoB. Análisis del ModeloA MANERA DE CONCLUSIÓNBIBLIOGRAFÍAEste trabajo es un ensayo presentado en la cátedra de Análisis Macroeconómico de la Maestría en Economía de la SEPEC-IIEE-ULA. Se coloca a disposición como un ejercicio de revisión teórica e implementación empírica de modelos de inflación, para la ayuda de los estudiantes que incursionan enel estudio del tema. Se advierte de la sencillez implícita del modelo [email protected] monográfic