1,718 research outputs found
Fluctuation theorem for currents in open quantum systems
A quantum-mechanical framework is set up to describe the full counting
statistics of particles flowing between reservoirs in an open system under
time-dependent driving. A symmetry relation is obtained which is the
consequence of microreversibility for the probability of the nonequilibrium
work and the transfer of particles and energy between the reservoirs. In some
appropriate long-time limit, the symmetry relation leads to a steady-state
quantum fluctuation theorem for the currents between the reservoirs. On this
basis, relationships are deduced which extend the Onsager-Casimir reciprocity
relations to the nonlinear response coefficients.Comment: 19 page
Green-Kubo formula for heat conduction in open systems
We obtain an exact Green-Kubo type linear response result for the heat
current in an open system. The result is derived for classical Hamiltonian
systems coupled to heat baths. Both lattice models and fluid systems are
studied and several commonly used implementations of heat baths, stochastic as
well as deterministic, are considered. The results are valid in arbitrary
dimensions and for any system sizes. Our results are useful for obtaining the
linear response transport properties of mesoscopic systems. Also we point out
that for systems with anomalous heat transport, as is the case in
low-dimensional systems, the use of the standard Green-Kubo formula is
problematic and the open system formula should be used.Comment: 4 page
Universal Properties of Nonlinear Response Functions of Nonequilibrium Steady States
We derive universal properties of nonlinear response functions of
nonequilibrium steady states. In particular, sum rules and asymptotic behaviors
are derived. Their consequences are illustrated for nonlinear optical materials
and nonlinear electrical conductors.Comment: 10 pages, 1 figure; added a few sentences and references to explain
detail
General properties of response functions of nonequilibrium steady states
We derive general properties, which hold for both quantum and classical
systems, of response functions of nonequilibrium steady states. We clarify
differences from those of equilibrium states. In particular, sum rules and
asymptotic behaviors are derived, and their implications are discussed. Since
almost no assumptions are made, our results are applicable to diverse physical
systems. We also demonstrate our results by a molecular dynamics simulation of
a many-body interacting system.Comment: After publication of this paper, several typos were found, which have
been fixed in the erratum (J. Phys. Soc. Jpn., 80 (2011) 128001). All the
corrections have been made in this updated arXive version. 13 pages with 3
figure
A meaningful expansion around detailed balance
We consider Markovian dynamics modeling open mesoscopic systems which are
driven away from detailed balance by a nonconservative force. A systematic
expansion is obtained of the stationary distribution around an equilibrium
reference, in orders of the nonequilibrium forcing. The first order around
equilibrium has been known since the work of McLennan (1959), and involves the
transient irreversible entropy flux. The expansion generalizes the McLennan
formula to higher orders, complementing the entropy flux with the dynamical
activity. The latter is more kinetic than thermodynamic and is a possible
realization of Landauer's insight (1975) that, for nonequilibrium, the relative
occupation of states also depends on the noise along possible escape routes. In
that way nonlinear response around equilibrium can be meaningfully discussed in
terms of two main quantities only, the entropy flux and the dynamical activity.
The expansion makes mathematical sense as shown in the simplest cases from
exponential ergodicity.Comment: 19 page
Current fluctuations in stochastic systems with long-range memory
We propose a method to calculate the large deviations of current fluctuations
in a class of stochastic particle systems with history-dependent rates.
Long-range temporal correlations are seen to alter the speed of the large
deviation function in analogy with long-range spatial correlations in
equilibrium systems. We give some illuminating examples and discuss the
applicability of the Gallavotti-Cohen fluctuation theorem.Comment: 10 pages, 1 figure. v2: Minor alterations. v3: Very minor alterations
for consistency with published version appearing at
http://stacks.iop.org/1751-8121/42/34200
Duplications at 19q13.33 in patients with neurodevelopmental disorders
Objective After the recent publication of the first patients with disease-associated missense variants in the GRIN2D gene, we evaluate the effect of copy number variants (CNVs) overlapping this gene toward the presentation of neurodevelopmental disorders (NDDs). Methods We exploredClinVar (number ofCNVs = 50,794) andDECIPHER (number ofCNVs = 28,085) clinical databases of genomic variations for patients with copy number changes overlapping the GRIN2D gene at the 19q13.33 locus and evaluated their respective phenotype alongside their frequency, gene content, and expression, with publicly available reference databases. Results We identified 11 patients with microduplications at the 19q13.33 locus. The majority of CNVs arose de novo, and comparable CNVs are not present in control databases. All patients were reported to have NDDs and dysmorphic features as the most common clinical phenotype (N = 8/11), followed by seizures (N = 6/11) and intellectual disability (N = 5/11). All duplications shared a consensus region of 405 kb overlapping 13 genes. After screening for duplication tolerance in control populations, positive gene brain expression, and gene dosage sensitivity analysis, we highlight 4 genes for future evaluation: CARD8, C19orf68, KDELR1, and GRIN2D, which are promising candidates for disease causality. Furthermore, investigation of the literature especially supports GRIN2D as the best candidate gene. Conclusions Our study presents dup19q13.33 as a novel duplication syndrome locus associated with NDDs. CARD8, C19orf68, KDELR1, and GRIN2D are promising candidates for functional follow-up.Peer reviewe
Quantitative evaluation of chromosomal rearrangements in gene-edited human stem cells by CAST-Seq
Genome editing has shown great promise for clinical translation but also revealed the risk of genotoxicity caused by off-target effects of programmable nucleases. Here we describe chromosomal aberrations analysis by single targeted linker-mediated PCR sequencing (CAST-Seq), a preclinical assay to identify and quantify chromosomal aberrations derived from on-target and off-target activities of CRISPR-Cas nucleases or transcriptional activator-like effector nucleases (TALENs), respectively, in human hematopoietic stem cells (HSCs). Depending on the employed designer nuclease, CAST-Seq detected translocations in 0%–0.5% of gene-edited human CD34+ HSCs, and up to 20% of on-target loci harbored gross rearrangements. Moreover, CAST-Seq detected distinct types of chromosomal aberrations, such as homology-mediated translocations, that are mediated by homologous recombination and not off-target activity. CAST-Seq is a sensitive assay able to identify and quantify unintended chromosomal rearrangements in addition to the more typical mutations at off-target sites. CAST-Seq analyses may be particularly relevant for therapeutic genome editing to enable thorough risk assessment before clinical application of gene-edited products
Rapid thermal processing of CuInSe2 electroplated precursors for CuIn(S,Se)2-based thin film solar cells
International audienceDuring the elaboration of standard CISEL™cells, electroplated CuInSe2 precursors undergo a rapid thermal processing (RTP) in a sulfur-containing atmosphere to promote grain growth and enable sulfurization of the precursor. The aim of this work is to show how structural and morphological properties of the CuIn(S,Se)2-based solar cells can be modified with RTP parameters, namely temperature, heating rate, and sulfur addition. X-ray diffractograms show that the preferential (112) orientation of the electrodeposited CuInSe2 precursor is maintained after annealing but the coefficient of crystallographic texture can be modified with specific RTP parameters. It is also shown that the quantity of sulfur incorporated in the chalcopyrite lattice can be controlled and reaches almost pure CuInS2 according to the sulfur quantity used during the RTP. Another effect of the RTP annealing is to form a Mo(S,Se)2 layer which can lead to a quasi-ohmic contact between the molybdenum and the absorber. The properties of the Mo(S,Se)2 buffer layer are also studied according to the process parameters and an increase of the annealing temperature or of the sulfur concentration tends to increase the thickness of this laye
An atomistic study of the structural changes in a Zr–Cu–Ni–Al glass-forming liquid on vitrification monitored in-situ by X-ray diffraction and molecular dynamics simulation
Structural changes in the Zr55Cu30Ni5Al10 liquid alloy on cooling from above the equilibrium liquidus temperature are studied by synchrotron radiation X-ray diffraction and compared with the results of first-principles molecular dynamics simulation. In-situ vitrification of the studied alloy is achieved using a containerless levitation technique. Subsequent analysis of the atomic and electronic structure of the alloy in liquid and glassy states reveals formation of medium-range order on cooling and its relationship with liquid fragility. The structural changes in this alloy are smaller in comparison with a more fragile one
- …