The European LEMS Registry: Baseline Demographics and Treatment Approaches

<p><b>Article full text</b></p> <p><br></p> <p>The full text of this article can be found here<b>.</b> <a href="https://link.springer.com/article/10.1007/s40120-015-0034-0">https://link.springer.com/article/10.1007/s40120-015-0034-0</a></p><p></p> <p><br></p> <p><b>Provide enhanced content for this article</b></p> <p><br></p> <p>If you are an author of this publication and would like to provide additional enhanced content for your article then please contact <a href="http://www.medengine.com/Redeem/”mailto:[email protected]”"><b>[email protected]</b></a>.</p> <p><br></p> <p>The journal offers a range of additional features designed to increase visibility and readership. All features will be thoroughly peer reviewed to ensure the content is of the highest scientific standard and all features are marked as ‘peer reviewed’ to ensure readers are aware that the content has been reviewed to the same level as the articles they are being presented alongside. Moreover, all sponsorship and disclosure information is included to provide complete transparency and adherence to good publication practices. This ensures that however the content is reached the reader has a full understanding of its origin. No fees are charged for hosting additional open access content.</p> <p><br></p> <p>Other enhanced features include, but are not limited to:</p> <p><br></p> <p>• Slide decks</p> <p>• Videos and animations</p> <p>• Audio abstracts</p> <p>• Audio slides</p

Additional file 1: of Selection bias in clinical stroke trials depending on ability to consent

Full dataset supporting the manuscript. (CSV 60 kb

Additional file 1: of Social work after stroke: identifying demand for support by recording stroke patients’ and carers’ needs in different phases after stroke

Recruitment and verbal consent. Description of recruitment as well as obtaining and documentation of consent. Data management. Description of data management and generation of the questionnaire. (DOCX 18 kb

Flow chart of the study population.

<p>Flow chart of the study population.</p

Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke

<p>This is the original dataset from the manuscript "Depletion of cultivatable gut microbiota by broad-spectrum antibiotic pretreatment worsens outcome after murine stroke" <a href="http://www.ncbi.nlm.nih.gov/pubmed/27056982#">Stroke.</a> 2016 Apr 7. pii: STROKEAHA.115.011800. [Epub ahead of print]</p

Exacerbation of ischemic injury in CBP^+/− primary cortical cultures.

<p><b>A</b>, Cortical neurons isolated from CBP^+/− mice or wild-type littermates were exposed at DIV 9 (<i>in vitro</i> day 9) to oxygen-glucose deprivation (OGD) for 75, 95 or 115 min. Lactate dehydrogenase (LDH) release was measured after 24 h as a marker to quantify neuronal death. Bar graphs represent the average LDH release of 4 independent experiments ± SEM. **<i>p</i><0.01; *<i>p</i><0.05. <b>B</b>, Representative result of Western blotting analyses of CBP^+/− mice and wild-type littermate cortical cultures using antibodies against ac-histone H4, ac-histone H4 and actin. <b>C</b>, Quantification of the Western blotting images was performed using ImageJ program and t test was conducted for statistical analyses. Bar graphs represent the mean values from 2 experiments ± SEM. *<i>p</i><0.05.</p

Lesion patterns of individual patients.

<p>Patient numbers correspond to patient IDs in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0082892#pone-0082892-t001" target="_blank">Table 1</a> (patients #2-10). No MRI was available for patient #1. Right side of the brain corresponds to right hemisphere.</p

Schematical drawing of the CM.

<p>Schematical drawing of the CM.</p

Demographic data and clinical characteristics of patients.

<p>Demographic data and clinical characteristics of patients.</p

Increased histone H4 acetylation and recruitment of CBP to gelsolin promoter region precedes transcriptional upregulation of gelsolin after ischemic preconditioning.

<p><b>A</b>, Rat cortical neurons were subjected to 30 min non-injurious preconditioning OGD and analyzed by chromatin immunoprecipitation (ChIP) with the indicated antibodies after 1 h interval following the preconditioning. Real time PCR results for gelsolin promoter were presented as mean fold enrichment ± SEM. **<i>p</i><0.01; *<i>p</i><0.05. N = 4 experiments. <b>B</b>, Rat cortical neurons were subjected to 30 min non-injurious preconditioning OGD or control treatment and analyzed by semi-quantitative real-time RT-PCR for gelsolin at the indicated time points. The data is shown as mean ± SEM. *p<0.05 versus vehicle. N = 3 experiments.</p