36 research outputs found
I dati Sentinel per un Framework GIS-based per la Gestione Integrata Costiera : una sperimentazione nel settore veneto della fascia costiera alto adriatica.
Il grande valore delle zone costiere e la loro potenzialit\ue0 hanno imposto di
trovare soluzione ai problemi che le affliggono, quali la distruzione degli
habitat, la contaminazione delle acque, l\u2019erosione costiera e l'impoverimento
delle risorse (UE Commission: ICZM a strategy for Europe COM 2000, Agenda
21).
L\u2019Integrated Coastal Zone Management (ICZM) sfrutta l\u2019analisi di vulnerabilit\ue0,
di pericolosit\ue0 e di rischio, naturale e antropico, quali imprescindibili
fondamenta conoscitive, specialmente per quelle risorse che hanno il carattere
di beni comuni.
Gli ambienti costieri sono sottoposti alla continua pressione esercitata da
grandi masse d'acqua in continuo movimento e apporti sedimentari dei fiumi
alla foce. Questi fattori, soprattutto nell\u2019alta fascia adriatica costiera, insieme
ad eustatismo e subsidenza, determinano la notevole dinamicit\ue0 che pu\uf2
manifestarsi in differenti forme e in significativa rapidit\ue0 di cambiamento.
Gli approcci tradizionali, nel ricorrere a delimitazioni cartografiche che non
sono capaci di restituire i veloci cambiamenti che intervengono, evidenziano
forti incongruenze con la realt\ue0 osservata. Quindi KPI, indici ed indicatori per le
predette analisi \u2013 implementate mediante tecniche e strumenti di analisi
geospaziale - necessitano di dati ad aggiornamento frequente che possono
essere ottenuti dal telerilevamento satellitare impiegato come piattaforma
informativa generalizzata.
Nel paper viene presentata una sperimentazione che sfrutta i dati delle
costellazioni Sentinel 1 e 2 del programma Copernicus dell\u2019ESA nel settore
veneto della fascia costiera adriatica. Tale sperimentazione \u2013 mirata alla
produzione di carte delle serie di vegetazione e all\u2019aggiornamento rapido della
perimetrazione delle aree ambientali protette - costituisce un primo stato di
avanzamento per la definizione di un framework ICZM generalizzabile per
applicazioni sulle coste europee ed africane
Investigating the inhibition of FTSJ1 a tryptophan tRNA-specific 2’-O-methyltransferase by NV TRIDs, as a mechanism of readthrough in nonsense mutated CFTR
Abstract: Cystic Fibrosis (CF) is an autosomal recessive genetic disease caused by mutations in the CFTR gene, coding for the CFTR chloride channel. About 10% of the CFTR gene mutations are "stop" mutations, which generate a Premature Termination Codon (PTC), thus synthesizing a truncated CFTR protein. A way to bypass PTC relies on ribosome readthrough, which is the ri-bosome’s capacity to skip a PTC, thus generating a full-length protein. “TRIDs” are molecules exerting ribosome readthrough; for some, the mechanism of action is still under debate. We in-vestigate a possible mechanism of action (MOA) by which our recently synthesized TRIDs, namely NV848, NV914, and NV930, could exert their readthrough activity by in silico analysis and in vitro studies. Our results suggest a likely inhibition of FTSJ1, a tryptophan tRNA-specific 2’-O-methyltransferase
Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression
Nonsense mutations cause several genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy, β-thalassemia, and Shwachman–Diamond syndrome. These mutations induce the formation of a premature termination codon (PTC) inside the mRNA sequence, resulting in the synthesis of truncated polypeptides. Nonsense suppression therapy mediated by translational readthrough-inducing drugs (TRIDs) is a promising approach to correct these genetic defects. TRIDs generate a ribosome miscoding of the PTC named “translational readthrough” and restore the synthesis of full-length and potentially functional proteins. The new oxadiazole-core TRIDs NV848, NV914, and NV930 (NV) showed translational readthrough activity in nonsense-related in vitro systems. In this work, the possible off-target effect of NV molecules on natural termination codons (NTCs) was investigated. Two different in vitro approaches were used to assess if the NV molecule treatment induces NTC readthrough: (1) a study of the translational-induced p53 molecular weight and functionality; (2) the evaluation of two housekeeping proteins’ (Cys-C and β2M) molecular weights. Our results showed that the treatment with NV848, NV914, or NV930 did not induce any translation alterations in both experimental systems. The data suggested that NV molecules have a specific action for the PTCs and an undetectable effect on the NTCs
Flood susceptibility assessment for improving the resilience capacity of railway infrastructure networks
Floods often cause significant damage to transportation infrastructure such as roads, railways, and bridges. This study identifies several topographic, environmental, and hydrological factors (slope, elevation, rainfall, land use and cover, distance from rivers, geology, topographic wetness index, and drainage density) influencing the safety of the railway infrastructure and uses multi-criteria analysis (MCA) alongside an analytical hierarchy process (AHP) to produce flood susceptibility maps within a geographic information system (GIS). The proposed methodology was applied to the catchment area of a railway track in southern Italy that was heavily affected by a destructive flood that occurred in the autumn of 2015. Two susceptibility maps were obtained, one based on static geophysical factors and another including triggering rainfall (dynamic). The results showed that large portions of the railway line are in a very highly susceptible zone. The flood susceptibility maps were found to be in good agreement with the post-disaster flood-induced infrastructural damage recorded along the railway, whilst the official inundation maps from competent authorities fail to supply information about flooding occurring along secondary tributaries and from direct rainfall. The reliable identification of sites susceptible to floods and damage may provide railway and environmental authorities with useful information for preparing disaster management action plans, risk analysis, and targeted infrastructure maintenance/monitoring programs, improving the resilience capacity of the railway network. The proposed approach may offer railway authorities a cost-effective strategy for rapidly screening flood susceptibility at regional/national levels and could also be applied to other types of linear transport infrastructures
Sicurezza Territoriale e gestione delle emergenze: soluzioni ed architetture per sistemi collaborativi
Intergraph's solutions for Public
Safety & Security, Critical Infrastructures Protection and Emergency Operation Centers Intergraph provides the world’s leading public safety dispatch system, which is accessed by more than half a billion people worldwide when they dial for emergency response. Because coordination with public safety
agencies during a large-scale event is so critical, Intergraph’s Computer- Aided Dispatch (I/CAD) system forms the basis for interagency coordination and management of operations and
serves as the foundation of the decision support process. I/CAD seamlessly integrates an interactive, realtime map display with call handling, dispatching, records and information management, remote and field access, analysis and models. Intergraph’s systems meet IT security requirements – such as DIACAP – and dispatch interoperability (APCO, CAP) without compromising performance. Built on standard interfaces, Intergraph products I/Sight, I/Sensor and I/Alarm Plus allow two-way communication with a variety of video, sensor and alarm types (I/Security Framework). At the same time, Intergraph offers a broad range of solutions for Emergency
Operations Centers (EOCs) and crisis management systems (I/PR, I2RMS, GIOTTO)
Smart City: aspetti geomatici di un paradigma “fuzzy”
Il concetto di Smart City viene proposto con molte varianti non sempre tra loro coerenti. Ne sceglieremol’accezione che propone la possibilità di una migliore qualità della vita negli spazi urbani rimpiazzandone lacaotica complessità con innovazioni tecnologiche per realizzare i nostri progetti di lavoro e di vita. All’interno delparadigma ci concentreremo sugli specifici aspetti del segmento disciplinare della geomatica.
Smart City: geomatics aspects of afuzzy paradigm
The label smart city is still quite a fuzzyconcept and is used in ways that arenot always consistent. We endorsethe definition that “a city can be definedas ‘smart’ when investments inhuman and social capital and traditional(transport) and modern (ICT)communication infrastructure fuelsustainable economic developmentand a high quality of life, with a wisemanagement of natural resources,through participatory governance”.Geomatics provides a set of conceptsand tools for the planningand management of Smart Cities(City Sensing,City Model, ProximalSensing, WIKI Sensing, etc). The IntegratedOperations Center (IOC)is the foundation using geographictechnologies to join Smart City withSafe City. Smart Grid Systems are away to make operational the urbansosteneability in the energy sector.Some Intergraph’s technologies areused as examples of the contributionof geomatics in the implementationof Smart City paradigm
Dal GIS all’SDI: le infrastrutture di dati geografici per la PAL
Per giungere ad una corretta definizione del fabbisogno di servizi GIS nella PAL è opportuno impostare un ragionamento relativo alla ridefinizione del ruolo dell’informazione geografica nei processi operativi della PAL stessa. Il problema al quale l’informatizzazione deve fornire una soluzione è, in generale, quello del riequilibrio dei rapporti tra gli stakeholders e il territorio, mediante strumenti di partecipazione ai processi decisionali e di sussidiarietà tra le PA
Dal GIS all’SDI: le infrastrutture di dati geografici per la PAL
Per giungere ad una corretta definizione del fabbisogno di servizi GIS nella PAL è opportuno impostare un ragionamento relativo alla ridefinizione del ruolo dell’informazione geografica nei processi operativi della PAL stessa. Il problema al quale l’informatizzazione deve fornire una soluzione è, in generale, quello del riequilibrio dei rapporti tra gli stakeholders e il territorio, mediante strumenti di partecipazione ai processi decisionali e di sussidiarietà tra le PA
Innovazione tecnologica e sinergie tra soluzioni geospaziali Lo "scenario Intergraph" (Parte Seconda)
Continua in quest'articolo la descrizione delle soluzioni geospatial del nuovo scenario Intergraph che si sta delineando a seguito della fusione di molti player del settore della geomatica al'interno del gruppo Hexagon AB. La prima parte di questo articolo è stata pubblicata su GEOmedia 4/2011.
Technological innovation and synergies between geospatial solutions. The "Intergraph's scenario". 2nd Part.
In October 2010, Intergraph was acquired by and is now a wholly owned subsidiary of Hexagon AB. Hexagon is a lead-ing global provider of precision measurement technology sys-tems. Intergraph Security, Government & Infrastructure (SG&I) provides geospatially powered solutions to the public safety and security, defense and intelligence, government, trans-portation, utilities, and communications industries. Now since ERDAS is part of Intergraph, Intergraph provides integrated products for remote sensing, photogrammetry, and geospatial data management and delivery. Using Leica sensors and tech-nologies enhanced by Intergraph-ERDAS software technolo-gies, IMoSS (another company of HEXAGON AB) is a reliable partner when it is needed to monitor, analyse and visualise movements at millimetre level accuracy and to trasform the monitoring data into actionable intelligence