Congenital Juvenile Xanthogranuloma of Foot, a Nodular Lesion: An Unusual Case in 2-month-old Infant

A 2-month-old infant presented with a circumscribed nodule on left foot since birth. Excision biopsy showed juvenile xanthogranuloma, an uncommon diagnosis in an unusual site; common sites being head and neck. Uncommon sites are groin, genital organs, limbs and even internal organs. It carries a favorable prognosis

Ayurveda considerations on Infectious diseases and their preventive measures w.s.r. to current pandemic situation

Ayurveda described term “Sankramaka Roga” for communicable diseases which mainly occurs due to the microbial transmissions. These diseases can transmit from one to anther through physical, chemical and biological means. The pathogenesis of such diseases arises due to the effect of microbial toxins inside the body. Antibiotics, lifestyle modification, immune-therapy, natural drugs, ayurveda formulations and purification measures, etc. are some approaches of various medical field which utilizes to prevent and treat Sankramaka Roga. The mass destruction of population by Sankramaka Roga termed as Janapadodhwamsa which resembles pandemic of modern science. Good immune system play vital role towards the prevention of Sankramaka Roga. Ayurveda concept of Ahara-Vihara helps greatly to boost immunity thus maintains good health status and enhances resistance against infectious diseases. This article explores Ayurveda view on Sankramaka Roga and their management through natural ways of healing

Adolescent Violence: Proneness Factors of Victims

Introduction: Approximately three-quarters of adolescents experience some type of victimization, either in school or as a whole in society. Their mental acumen is not strong enough due to various reasons to resolve this age-related crisis and pushing them in a web of stress. The attitude of victim is influenced by his self-social image, personality and behavior which provide the space to the perpetrator of the offence. Materials and Methods: A cross-sectional survey, using a pretested self-report questionnaire was conducted on 960 students aged 10–18 years of urban schools regarding the indulgence in violence as victims during the last one year.Observations: The prevalence of victimization was 18.33% while in male and female it was 59.09% and 40.90% in their respective groups. Parents possessing education less than high school produce the highest numbers of victims. 65.34% victims were staying with both parents and 19.88%, 63.63%, 55.11% and 35.79% were in habit of smoking, alcohol and tobacco use respectively.Discussion and Conclusion: Research studies have shown that the behavior can be modified and the proneness factors can be reduced or eliminated. Every child’s individuality should be appreciated for the value, rather than suppressed to reduce the risk of victimization. Not all children are able to alter their personal characteristics that may place them at increased risk. To benefit the society, the segregation and counselling of such students at school level is the only answer of this problem

Structural stabilization of GTP-binding domains in circularly permuted GTPases: Implications for RNA binding

GTP hydrolysis by GTPases requires crucial residues embedded in a conserved G-domain as sequence motifs G1–G5. However, in some of the recently identified GTPases, the motif order is circularly permuted. All possible circular permutations were identified after artificially permuting the classical GTPases and subjecting them to profile Hidden Markov Model searches. This revealed G4–G5–G1–G2–G3 as the only possible circular permutation that can exist in nature. It was also possible to recognize a structural rationale for the absence of other permutations, which either destabilize the invariant GTPase fold or disrupt regions that provide critical residues for GTP binding and hydrolysis, such as Switch-I and Switch-II. The circular permutation relocates Switch-II to the C-terminus and leaves it unfastened, thus affecting GTP binding and hydrolysis. Stabilizing this region would require the presence of an additional domain following Switch-II. Circularly permuted GTPases (cpGTPases) conform to such a requirement and always possess an ‘anchoring’ C-terminal domain. There are four sub-families of cpGTPases, of which three possess an additional domain N-terminal to the G-domain. The biochemical function of these domains, based on available experimental reports and domain recognition analysis carried out here, are suggestive of RNA binding. The features that dictate RNA binding are unique to each subfamily. It is possible that RNA-binding modulates GTP binding or vice versa. In addition, phylogenetic analysis indicates a closer evolutionary relationship between cpGTPases and a set of universally conserved bacterial GTPases that bind the ribosome. It appears that cpGTPases are RNA-binding proteins possessing a means to relate GTP binding to RNA binding

Design de fiabilidade bidimensional do software de múltiplos lançamentos tendo em conta o fator de redução de falhas na depuração imperfeita

Introduction: The present research was conducted at the University of Delhi, India in 2017. Methods: We develop a software reliability growth model to assess the reliability of software products released in multiple versions under limited availability of resources and time. The Fault Reduction Factor (frf) is considered to be constant in imperfect debugging environments while the rate of fault removal is given by Delayed S-Shaped model. Results: The proposed model has been validated on a real life four-release dataset by carrying out goodness of fit analysis. Laplace trend analysis was also conducted to judge the trend exhibited by data with respect to change in the system’s reliability. Conclusions: A number of comparison criteria have been calculated to evaluate the performance of the proposed model relative to only time-based multi-release Software Reliability Growth Model (srgm). Originality: In general, the number of faults removed is not the same as the number of failures experienced in given time intervals, so the inclusion of frf in the model makes it better and more realistic. A paradigm shift has been observed in software development from single release to multi release platform. Limitations: The proposed model can be used by software developers to take decisions regarding the release time for different versions, by either minimizing the development cost or maximizing the reliability and determining the warranty policies.Introducción: la presente investigación se realizó en la Universidad de Delhi, India en 2017. Métodos: desarrollamos un modelo de crecimiento de confiabilidad de software para evaluar la confiabilidad de los productos de software lanzados en múltiples versiones bajo disponibilidad limitada de recursos y tiempo. El factor de reducción de fallas (frf) se considera una constante en entornos de depuración imperfecta, mientras que la tasa de eliminación de fallas está dada por el modelo de forma retardada en S. Resultados: se valida el modelo propuesto en un conjunto de datos de cuatro lanzamientos de la vida real mediante un análisis de bondad de ajuste. También se aplicó el análisis de tendencia de Laplace para juzgar la tendencia que presentan los datos con respecto al cambio en la confiabilidad del sistema. Conclusiones: se calculó una serie de criterios de comparación para evaluar el rendimiento del modelo propuesto en relación con el modelo de crecimiento de confiabilidad del software (srgm) de múltiples lanzamientos basado únicamente en el tiempo. Originalidad: en general, el número de fallas eliminadas no es el mismo que el número de fallas experimentadas en intervalos de tiempo determinados, por lo que la inclusión de frf en el modelo lo mejora y lo hace más realista. Se ha observado un cambio de paradigma en el desarrollo de software, que pasa de un lanzamiento único a una plataforma múltiples lanzamientos. Limitaciones: los desarrolladores de software pueden emplear el modelo propuesto para tomar decisiones con respecto al tiempo de lanzar diferentes versiones, ya sea minimizando el costo de desarrollo o maximizando la confiabilidad y determinando las políticas de la garantía.Introdução: esta pesquisa foi realizada na Universidade de Deli, na Índia, em 2017. Métodos: desenvolvemos um modelo de crescimento de confiabilidade de software para avaliar a confiabilidade dos produtos de software lançados em múltiplas versões sob disponibilidade limitada de recursos e tempo. O fator de redução de falhas (frf) é considerado uma constante em contextos de depuração imperfeita, enquanto a taxa de eliminação de falhas é dada pelo modelo de forma retardada em S.Resultados: o modelo proposto é avaliado em um conjunto de dados de quatro lançamentos da vida real mediante uma análise de bondade de ajuste. Também foi utilizada a análise de tendência de Laplace para avaliar a tendência apresentada pelos dados com respeito à mudança na confiabilidade do sistema.Conclusões: uma série de critérios de comparação foi calculada para avaliar o rendimento do modelo proposto em relação com o modelo de crescimento de confiabilidade do software (srgm) de múltiplos lançamentos baseado unicamente no tempo.Originalidade: em geral, o número de falhas eliminadas não é o mesmo que o número de falhas existentes em intervalos de tempo determinados, sendo assim, a inclusão do frf no modelo o torna melhor e mais realista. Foi observada uma mudança de paradigma no desenvolvimento de software, que passa de um lançamento único a uma plataforma de múltiplos lançamentos.Limitações: o modelo proposto pode ser utilizado pelos desenvolvedores de software para tomar decisões com respeito ao tempo de lançar diferentes versões, seja para minimizar o custo de desenvolvimento ou maximizar a confiabilidade e determinar as políticas de garantia

Diversity in Fashion Recommendation using Semantic Parsing

Developing recommendation system for fashion images is challenging due to the inherent ambiguity associated with what criterion a user is looking at. Suggesting multiple images where each output image is similar to the query image on the basis of a different feature or part is one way to mitigate the problem. Existing works for fashion recommendation have used Siamese or Triplet network to learn features between a similar pair and a similar-dissimilar triplet respectively. However, these methods do not provide basic information such as, how two clothing images are similar, or which parts present in the two images make them similar. In this paper, we propose to recommend images by explicitly learning and exploiting part based similarity. We propose a novel approach of learning discriminative features from weakly-supervised data by using visual attention over the parts and a texture encoding network. We show that the learned features surpass the state-of-the-art in retrieval task on DeepFashion dataset. We then use the proposed model to recommend fashion images having an explicit variation with respect to similarity of any of the parts.Comment: 5 pages, ICIP2018, code: https://github.com/sagarverma/fashion_recommendation_stlst

Role of Viruddha Ahara towards Skin and Allergic Disorders; an Ayurveda Review

Viruddha Ahara is Ayurveda view of food incompatibility; Viruddha Ahara referred several types of food incompatibility including food–food interactions and food processing interactions, etc. Diet and its combinations that affects metabolism of tissue, inhibits process of tissue formation, alter physiological process of body and having opposite property, etc. are termed as Viruddha Ahara or incompatible food. The inappropriate quantity and quality of food and improper timing of meal, etc. also comes under the heading of Viruddha Ahara. With respect to concept of Viruddha Ahara Ayurveda has described different food incompatibilities i.e.; Samskar Viruddha, Samyoga Viruddha and Veerya Viruddha, etc. Viruddha ahara can triggers pathogenesis of several diseases including Visarpa, intoxication, Shukra Dhatu Dushti, rhinitis, infertility, Kustha roga and allergic disorders, etc. Present article explored role of Viruddha ahara in skin and allergic disorders

THE STUDY OF ANTIOXIDANTS TO EVALUATE THE HEALING EFFECTS OF PUNICA GRANATUM PEEL ON ACETIC ACID-INDUCED COLITIS IN CHARLES-FOSTER ALBINO RATS

Objective: The study aims to analyze the effect of 50% ethanolic extract of the dried Punica granatum peel (PGE) on the healing of acetic- acid-induced colitis in rats. Methods: Colitis was induced in rats using 50% acetic acid and then PGE extract was administered by oral route daily for 14 days to those rats. Optimal healing was observed by the administration of a 100 mg/kg dose of PGE extract. Effectiveness of the above-mentioned dosage of PGE, biochemical parameters namely- antioxidants-superoxide dismutase and reduced glutathione were studied on 18 h fasting rats on the 15th day of the experiment. Results: The results were suggestive of the healing properties of PGE extract by reduction of the inflammation and mucosal damage in the colon of those rats. The effect was established by the levels of antioxidants that indicate healing of the mucosal damage. The safety of extract was established by the effective administration of 10 times the therapeutic dose, that is, 1000 mg/kg dosage of the PGE extract with no noticeable adverse effects or side effects related to autonomic nervous system or central nervous system. Conclusion: PGE extract was found to be effective in healing mucosal damage due to colitis by controlling the infection and reducing the inflammation