A Magyar Tudományos Akadémia Meteorológiai Tudományos Bizottságának állásfoglalása éghajlatunk jövőjéről

Short-form of the State Scale of the Spielberger State-Trait Anxiety Inventory. (PDF 15 kb

Clinical characteristics of women choosing NIPT, CVS and amniocentesis.

<p>Clinical characteristics of women choosing NIPT, CVS and amniocentesis.</p

Women segmentation in prenatal testing based on values capital and intellectual capital.

<p>Women segmentation in prenatal testing based on values capital and intellectual capital.</p

Factors that affected women’s choice on further tests in terms of values, behavioral beliefs, subjective norms and perceived choice control.

<p>Factors that affected women’s choice on further tests in terms of values, behavioral beliefs, subjective norms and perceived choice control.</p

Additional file 4: of Facilitating autonomous, confident and satisfying choices: a mixed-method study of women’s choice-making in prenatal screening for common aneuploidies

Measurements (before factor analysis). (DOCX 16 kb

Additional file 5: of Facilitating autonomous, confident and satisfying choices: a mixed-method study of women’s choice-making in prenatal screening for common aneuploidies

Factor analysis result. (DOCX 13 kb

Additional file 2: of Facilitating autonomous, confident and satisfying choices: a mixed-method study of women’s choice-making in prenatal screening for common aneuploidies

Decisional Conflict Scale. (PDF 116 kb

Additional file 1: of FLIPL is critical for aerobic glycolysis in hepatocellular carcinoma

Table S1. Statistical results for FLIPL expression in the adjacent normal specimens of 79 HCC. Table S2. Statistical results of SGLT1 expression in the adjacent normal specimens of 79 HCC. (DOCX 17 kb

Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner

Macroautophagy/autophagy-mediated anoikis resistance is crucial for tumor metastasis. As a key autophagy-related protein, ATG4B has been demonstrated to be a prospective anti-tumor target. However, the existing ATG4B inhibitors are still far from clinical application, especially for tumor metastasis. In this study, we identified a novel circRNA, circSPECC1, that interacted with ATG4B. CircSPECC1 facilitated liquid-liquid phase separation of ATG4B, which boosted the ubiquitination and degradation of ATG4B in gastric cancer (GC) cells. Thus, pharmacological addition of circSPECC1 may serve as an innovative approach to suppress autophagy by targeting ATG4B. Specifically, the circSPECC1 underwent significant m6A modification in GC cells and was subsequently recognized and suppressed by the m6A reader protein ELAVL1/HuR. The activation of the ELAVL1-circSPECC1-ATG4B pathway was demonstrated to mediate anoikis resistance in GC cells. Moreover, we also verified that the above pathway was closely related to metastasis in tissues from GC patients. Furthermore, we determined that the FDA-approved compound lopinavir efficiently enhanced anoikis and prevented metastasis by eliminating repression of ELAVL1 on circSPECC1. In summary, this study provides novel insights into ATG4B-mediated autophagy and introduces a viable clinical inhibitor of autophagy, which may be beneficial for the treatment of GC with metastasis.</p

Pre-exposure to 50 Hz-EMFs enhanced the antiproliferative efficacy of 5-FU in breast cancer cell line MCF-7.

<p>(A) For EMF exposure time assay, MCF7 cells were exposed to 50 Hz-EMF (1 mT) for 0, 2, 4, 8 and 12 h; then, the cells were treated with 5 μM 5-FU for 24 h, and cell viability was analyzed by the MTT assay. (B) For 5-FU concentration assay, MCF7 cells were exposed to 50 Hz-EMF (1 mT) for 12 h; then, the cells were treated with 1, 2.5, 5 or 10 μM 5-FU for 24 h, and cell viability was analyzed by the MTT assay. (C) MCF7 cells were exposed to 50 Hz-EMF (1 mT) for 12 h; then, the cells were treated with 5 μM 5-FU for 24 h, and cell apoptosis was measured by flow cytometry. (D) and (E) MCF10A cells were subjected to the same treatment as in (A) and (B), respectively. n = 3, *p < 0.05, **p < 0.01.</p