Optimization of the Actuation System Sizing of a New Helicopter base on Global Modeling Approach

International audienceThe achievements presented in this communication propose a model based approach to propagate the Flight Control System requirements to the actuation system with the aim to identify each subsystem contribution and then think a global optimization of the actuation system architecture and sizing. Within the helicopter’s Flight Control System, many functions are encapsulated, making the global performance dependent of each subsystem. Hydraulic power generation and distribution impact the actuators performances, which dynamics are influencing the global helicopter control loop performances. After presenting some recommendations in terms of pipes and actuators sizing, the new global modeling approach is introduced. The actuation system model is described with its interfaces, including degrees of freedom on its architecture, and its key parameters. Open loop simulations – based on real flight data – and closed loop simulation – responses to commands needed for maneuvers – are detailed with their respective advantages. The contribution of this global modeling approach to the final design is presented and perspectives are given

Optimization of the Actuation System Sizing of a New Helicopter base on Global Modeling Approach

International audienceThe achievements presented in this communication propose a model based approach to propagate the Flight Control System requirements to the actuation system with the aim to identify each subsystem contribution and then think a global optimization of the actuation system architecture and sizing. Within the helicopter’s Flight Control System, many functions are encapsulated, making the global performance dependent of each subsystem. Hydraulic power generation and distribution impact the actuators performances, which dynamics are influencing the global helicopter control loop performances. After presenting some recommendations in terms of pipes and actuators sizing, the new global modeling approach is introduced. The actuation system model is described with its interfaces, including degrees of freedom on its architecture, and its key parameters. Open loop simulations – based on real flight data – and closed loop simulation – responses to commands needed for maneuvers – are detailed with their respective advantages. The contribution of this global modeling approach to the final design is presented and perspectives are given

Effects of single-agent bortezomib as post-transplant consolidation therapy on multiple myeloma-related bone disease: a randomized phase II study

This phase II study explored the effects of bortezomib consolidation versus observation on myeloma-related bone disease in patients who had a partial response or better after frontline high-dose therapy and autologous stem cell transplantation. Patients were randomized to receive four 35-day cycles of bortezomib 1·6 mg/m2 intravenously on days 1, 8, 15 and 22, or an equivalent observation period, and followed up for disease status/survival. The modified intent-to-treat population included 104 patients (51 bortezomib, 53 observation). There were no meaningful differences in the primary endpoint of change from baseline to end of treatment in bone mineral density (BMD). End-of-treatment rates (bortezomib versus observation) of complete response/stringent complete response were 22% vs. 11% (P = 0·19), very good partial response or better of 80% vs. 68% (P = 0·17), and progressive disease of 8% vs. 23% (P = 0·06); median progression-free survival was 44·9 months vs. 21·8 months (P = 0·22). Adverse events observed ≥15% more frequently with bortezomib versus observation were diarrhoea (37% vs. 0), peripheral sensory neuropathy (20% vs. 4%), nausea (18% vs. 0) and vomiting (16% vs. 0). Compared with observation, bortezomib appeared to have little impact on bone metabolism/health, but was associated with trends for improved myeloma response and survival. © 2017 John Wiley & Sons Lt