Alteration of the Small Cell Lung Cancer Phenotype and Its Effect on Chemosensitivity

Small cell lung cancer (SCLC) accounts for approximately 25% of all lung cancers. It is distinguished from other lung cancers by the presence of neurosecretory granules, frequent peptide secretion, high levels of L-DOPA decarboxylase (DDC), creatine kinase BB isoenzyme (CKBB) ,neurone specific enolase (NSE) and bombesin-like immunoreactivity (BLI). It is a particularly aggressive neoplasm which has the potential for early metastatic dissemination, and by the time of diagnosis metastatic spread is often extensive. Consequently, surgical removal of the tumour is in most cases unlikely to result in a cure from the disease and chemotherapy is the most important treatment modality for SCLC. The eventual goal in the treatment of SCLC is to develop effective systemic therapy that will produce high response rates and a high percentage of long term disease-free survivors (cures)

New Genera and Species of Fossil Marine Amioid Fishes (Actinopterygii, Holostei) from the Late Cretaceous Agoult locality in Southeastern Morocco

The document is Terry C. Grande\u27s (et al.) abstract in the Society of Vertebrate Paleontology 77th Annual Meeting Program and Abstracts

Tau Aggregation Inhibitor Therapy : An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

ACKNOWLEDGMENTS We thank patients and their caregivers for their participation in the study and are indebted to all the investigators involved in the study, particularly Drs. Douglas Fowlie and Donald Mowat for their helpful contributions to the clinical execution of the study in Scotland. We thank Sharon Eastwood, Parexel, for assistance in preparing initial drafts of the manuscript. We acknowledge constructive comments provided by Professors G. Wilcock and S. Gauthier on drafts of the article. CMW, CRH, and JMDS are officers of, and hold beneficial interests in, TauRx Therapeutics. RTS, PB, KK, and DJW are paid consultants to TauRx Therapeutics. The study was financed entirely by TauRx TherapeuticsPeer reviewedPublisher PD

Cortical Thickness and Surface Area Networks in Healthy Aging, Alzheimer’s Disease and Behavioral Variant Fronto-Temporal Dementia

Acknowledgments We would like to acknowledge the support of the Maxwell compute cluster funded by the University of Aberdeen. We also gratefully acknowledge study investigators and the generosity of study participants.Peer reviewedPublisher PD

Evidence for Circumpolar Distribution of Planktonic Archaea in the Southern Ocean

Surveys using rRNA-targeted probes specific for the 3 domains of life (Eucarya, Archaea, and Bacteria) indicated the presence, and at times high abundance, of archaeal rRNA in a variety of water masses surrounding Antarctica. Hybridization signals of archaeal rRNA contributed significantly to that of total picoplankton rRNA both north and south of the Polar Front in Drake Passage. Late winter surface water populations collected around the South Shetland Islands also yielded relatively high archaeal rRNA hybridization signals, approaching 10% or greater of the total rRNA. Summer samples collected in the western region of the Antarctic Peninsula and at McMurdo Sound in the Ross Sea region of Antarctica yielded lower amounts of archaeal rRNA in the surface waters, and higher levels of archaeal rRNA at depth (150 to 500 m). The hybridization data were compared to biological, chemical, and hydrographic information when possible. In surface waters, archaeal rRNA and chlorophyll a varied inversely. The data presented here further supports the hypothesis that planktonic archaea are a common, widespread and likely ecologically important component of Antarctic picoplankton assemblages. The presence of these archaea in circumpolar deep water suggests a conduit for their circumpolar transport around Antarctica via the Antarctic Circumpolar Current, as well as their export to the deep sea, or to intermediate waters of the South Atlantic via mixing at the polar front

Validation and comparison of two automated methods to quantify brain white matter hyperintensities of presumed vascular origin

Funding Data collection was funded by grants from the Alzheimer’s Research Trust (now Alzheimer’s Research UK, grant reference: ART/SPG2003B), Alzheimer’s Research UK (grant reference: ARUK-SB2012B-2), the University of Aberdeen Development Trust (grant reference RGB3109) and NHS Grampian and the Chief Scientist’s Office (grant reference: CAF/08/08). JMJW is funded by the University of Aberdeen Development Trust and TauRx Therapeutics Ltd. CP is funded by Royal Surrey County Hospital NHS Foundation Trust. CJM, ADM, and GDW are funded by the Scottish Funding Council.Peer reviewedPublisher PD

A Tribute to Joseph Schieser Nelson, 1937–2011

2.0Full digital generat a partir de la base topogràfica 1:5 000. Els fulls d'aquesta sèrie corresponen a la divisió 4 x 4 de la malla de distribució del Mapa topográfico nacional de España 1:50 000. Cada full inclou 2 finestres (Mapa índex de la sèrie; Mapa guia). - Projecció Universal Transversa Mercator (UTM), fus 31, sobre el·lipsoide internacional i datum europeu. Equidistància de les corbes de nivell: 5 m.Imatge digital de 90 x 67 cm1:5 000300 PP